Lack of association of primary iron overload and common HFE gene mutations with liver cirrhosis in adult Indian population

Jain, Shalu; Agarwal, Sarita; Tamhankar, Parag M; Verma, Prashant Kumar; Choudhuri, Gourdas

doi:10.1007/s12664-011-0109-5

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…In our study we tried to demonstrate that the epidemiology of the HH and HFE gene mutation in Iran is completely different from that found in the West, and also to emphasize the infrequency of the C282Y mutation in Iran [2]. In recent publications from countries such as India, similar results were found and all the data were in favor of a minor contributory role of HH in the development of cirrhosis in these countries which is different from in the West [3]. Finally I want to emphasize the effect that the presence of the HFE gene mutation has on the fibrogenesis of other liver diseases such as alcoholic or viral hepatitis [4] and this should be investigated in future studies in Iran.…”

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confidence: 68%

Author’s Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis

Geramizadeh¹

2012

Hpat Mon

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confidence: 68%

Author’s Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis

Geramizadeh¹

2012

Hpat Mon

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“…In our study, the least iron content in the liver was found in the patients with biliary cirrhosis, which has also been reported by Batts ( 8 ). It seems that stainable iron in biliary cirrhosis is rare and, if present, the amount of stainable iron is low ( 17 , 18 ). In none of our Prussian-blue slides of biliary cirrhosis was the whole tissue loaded with iron.…”

Section: Discussionmentioning

confidence: 99%

A Single Center Study Comparing the Stainable Iron Depositions in 1000 Explanted Cirrhotic Livers of Different Causes

et al. 2015

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Background:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder.Objectives:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis.Patients and Methods:In this 7 year study (2008 - 2014), in 1000 explanted livers, the amount of iron was scored and compared according to the cause of the cirrhosis. The amount of iron in the liver was determined via the histochemical staining of the liver tissue, using Prussian-blue staining. Additionally, in each patient, the serum iron was determined and compared according to the cause of cirrhosis.Results:The highest content of iron has been found in cirrhosis caused by chronic hepatitis (i.e. hepatitis B, C, and autoimmune hepatitis), as well as in alcoholic cirrhosis. The least amount of stainable iron has been shown in biliary cirrhosis.Conclusions:The presence of high stainable iron in patients with cirrhosis, secondary to chronic viral hepatitis, autoimmune hepatitis, and alcoholic hepatitis, should not be considered indicative of the presence of hereditary hemochromatosis; however, in those patients with biliary cirrhosis, a high iron content is rare, and can be a sign of the presence of the high iron Fe (HFE) gene mutation, or another type of hereditary hemochromatosis.

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“…The mutations though not studied in CVI, are thought to be rare in the Indian population. [5][6][7][8][9][10][11][12][13][14] This may explain the absence of accumulation and excretion of haemosiderin-alternative disease causation is thus postulated as a mechanism of disease.…”

Section: Discussionmentioning

confidence: 99%

Urinary hemosiderin: role in evaluation of chronic venous insufficiency

Shrestha

Sen

Stephen

et al. 2012

Veins and Lymphatics

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Chronic venous insufficiency (CVI) leads to skin changes with dermal hemosiderin deposition. We studied the presence of hemosiderin in the urine to assess if this could be used as a biochemical marker for CVI. Hereby we present a case control study conducted in a tertiary care centre in South India. There were 100 cases with evidence of advanced CVI (the Clinical-Etiology-Anatomy-Pathophysiology classification: C5, C6) confirmed by duplex scanning. Controls were 50 patients with leg ulcers due to other etiologies. All patients were subjected to urinary hemosiderin testing. In all 100 patients with CVI (C5 and C6 disease) axial venous reflux was confirmed by duplex ultrasound. Superficial venous reflux was noted in 71% of patients and deep venous reflux in 54.%. Primary venous insufficiency was the etiology in 81% of patients. Only 4/100 patients had detectable amounts of hemosiderin in the urine. Urine hemosiderin testing to determine presence or absence of CVI yielded the following values: positive predictive value-80%; negative predictive value-33%; sensitivity-4% and specificity-98%. The test could not be recommended as a marker of CVI. In Indian patients urinary hemosiderin is not a useful screening test in CVI.

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Lack of association of primary iron overload and common HFE gene mutations with liver cirrhosis in adult Indian population

Cited by 19 publications

References 23 publications

Author’s Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis

Author’s Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis

A Single Center Study Comparing the Stainable Iron Depositions in 1000 Explanted Cirrhotic Livers of Different Causes

Urinary hemosiderin: role in evaluation of chronic venous insufficiency

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