Lack of association of serum lipoprotein (a) levels with type-2 diabetes mellitus in patients with angiographically defined coronary artery disease

Pedreño, Javier; Fernández, Ramón; Ballester, A Herrera; Jornet, A.; Uson, Mariano; Canela, Jaume; Petit, M.

doi:10.1016/s0167-5273(00)00304-1

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…As for the association of Lp(a) levels with CAD extent in diabetic patients, our data are in agreement with those of Watts et al [15], but they are in contrast with those of Okada et al [16] and Pedreno et al [17]. It is possible that differences among the studies may be caused by the small diabetic populations enrolled in previous studies [23 -25], but also by different selection criteria.…”

Section: Discussionsupporting

confidence: 89%

Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Gazzaruso

Bruno

Pujia

et al. 2006

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 89%

Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Gazzaruso

Bruno

Pujia

et al. 2006

International Journal of Cardiology

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“…Numerous studies have shown that elevated serum level of Lp (a) is an independent risk factor for CAD in nondiabetic subjects, but its contributions to atherosclerosis in diabetes remains in controversy [9-12]. In the present study, Lp (a) was found to be an independent risk factor for CAD development in a diabetic cohort, while HDL-C, LDL-C, total cholesterol, triglyceride, hypertension, and cigarette smoking did not enter this model, suggesting that these traditional risk factors were not risk factors for CAD development in these diabetic subjects.…”

Section: Discussionmentioning

confidence: 99%

Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes

Lü

et al. 2006

Cardiovasc Diabetol

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BackgroundCoronary artery disease (CAD) is a major vascular complication of diabetes mellitus and reveals high mortality. Up to 30% of diabetic patients with myocardial ischemia remain asymptomatic and are associated with worse prognosis compared to non-diabetic counterpart, which warrants routine screening for CAD in diabetic population. The purpose of this study was to evaluate the clinical value of serum glycated albumin and high-sensitivity C-reactive protein (hs-CRP) levels in predicting the presence of CAD in patients with type 2 diabetes.MethodsThree hundred and twenty-four patients with type 2 diabetes were divided into two groups based on presence (CAD group, n = 241) or absence (control group, n = 83) of angiographically-documented CAD (lumen diameter narrowing ≥70%). Serum levels of glycated albumin and hs-CRP as well as serum concentrations of glucose, lipids, creatinine, blood urea nitrogen and uric acid were measured in both groups. Predictors of CAD were determined using multivariate logistic regression model and receiver-operating characteristic (ROC) curves.ResultsSerum glycated albumin and hs-CRP levels were significantly increased in diabetic patients with CAD. Multivariate regression analysis revealed that male gender, age, serum levels of glycated albumin, hs-CRP, creatinine and lipoprotein (a) were independent predictors for CAD. Areas under the curve of glycated albumin and hs-CRP and for regression model were 0.654 (95%CI 0.579–0.730, P < 0.001), 0.721 (95%CI 0.658–0.785, P < 0.001) and 0.824 (95% CI 0.768–0.879, P < 0.001), respectively. The optimal values of cut-off point were 18.7% (sensitivity 67.9%, specificity 60.0%) for glycated albumin and 5.2 mg/l (sensitivity 72.2%, specificity 60.0%) for hs-CRP to predict CAD. Logistic regression model was defined as: P/(1-P) = EXP(-1.5 + 1.265 gender + 0.812 age + 1.24 glycated albumin + 0.953 hs-CRP + 0.902 lipoprotein(a) + 1.918 creatinine). The optimal probability value for predicting CAD in type 2 diabetic patients was 0.648 (sensitivity 82.3%, specificity 68.6%).ConclusionSerum glycated albumin and hs-CRP levels were significantly elevated in patients with type 2 diabetes and CAD. The logistic regression model incorporating with glycated albumin, hs-CRP and other major risk factors of atherosclerosis may be useful for screening CAD in patients with type 2 diabetes.

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“…[8][9][10][11][12][13] Several studies indicated that Lp(a) might initiate atherosclerosis 14,15 and possibly promote thrombosis at very high levels, 16 while other data did not support the notion that Lp(a) was an independent predictor for CVD risk. 17 At the same time, few studies have analysed the relationship between serum Lp(a) levels and the severity of coronary artery disease (CAD), in particular using the well-recognized quantitative coronary scores in a large sample size. More importantly, less data are currently available in diabetes, a unique diseased state with significant disorder of metabolism including dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Role of lipoprotein(a) in predicting the severity of new on-set coronary artery disease in type 2 diabetics: A Gensini score evaluation

Chen

Zhang

et al. 2015

Diabetes and Vascular Disease Research

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The objective of the study was to investigate the usefulness of serum lipoprotein(a) level in predicting the severity of new on-set coronary artery disease in type 2 diabetics. A total of 1254 new on-set, consecutive coronary artery disease patients were classified into two groups: diabetes group (n = 380) and non-diabetes group (n = 874). The relationship between serum lipoprotein(a) levels and the severity of coronary artery disease assessed by Gensini score was analysed. Data showed that the diabetes group had higher serum triglyceride and high sensitivity C-reactive protein levels but lower high-density lipoprotein cholesterol levels (all p < 0.05). The multivariate logistic regression analysis suggested that lipoprotein(a) was an independent predictor for high Gensini score (odds ratio = 1.82, 95% confidence interval: 1.10-3.12, p = 0.029) after adjusting for traditional cardiovascular risk factors. Additionally, lipoprotein(a) levels were positively correlated with Gensini score (rho = 0.15, p = 0.014) and significantly elevated according to the tertiles of Gensini score (p = 0.008) in diabetics. However, no such results were observed in non-diabetics. Our data indicate that lipoprotein(a) is an independent predictor for the severity of new on-set coronary artery disease patients accompanied by type 2 diabetes, suggesting that these patients may benefit from lipoprotein(a) management in clinical assessment.

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Lack of association of serum lipoprotein (a) levels with type-2 diabetes mellitus in patients with angiographically defined coronary artery disease

Cited by 16 publications

References 24 publications

Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes

Role of lipoprotein(a) in predicting the severity of new on-set coronary artery disease in type 2 diabetics: A Gensini score evaluation

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