Lack of association of the angiotensin converting enzyme gene polymorphism with essential hypertension in a chinese population

Chiang, Fu-Tien; Lai, Zu-Ping; Chern, Tser-Haw; Tseng, Chuen-Den; Hsu, Kwan-Lih; Lo, Huey‐Ming; Tseng, Yung‐Zu

doi:10.1016/s0895-7061(96)00345-7

Cited by 58 publications

(60 citation statements)

References 23 publications

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“…Various reports described the D allele as a risk factor for essential hypertension in various populations 6,7 whereas other studies disagree with that hypothesis. [8][9][10][11][12][13] Our work is, to our knowledge, the first one to be done in a Mediterranean population, and reveals no association between the I/D polymorphism and BP (Table 2). When we tested the serum activity of ACE in all of the individuals (fifth quintyl and first quintyl groups) it showed significantly higher values in individuals with more D alleles (DDϾDIϾII).…”

Section: Discussionmentioning

confidence: 96%

“…[1][2][3] The D allele was reported to be a risk factor for several cardiovascular diseases including myocardial infarction, left ventricular hypertrophy and essential hypertension in some populations under study, 4-7 but could not later be proven in others. [8][9][10][11][12][13] To our knowledge there is no evidence of any genetic study of ACE performed in a Mediterranean population.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin-converting enzyme (ACE) gene polymorphisms, serum ACE activity and blood pressure in a Spanish-Mediterranean population

et al. 2000

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Angiotensin-converting enzyme (ACE) levels and ACE gene polymorphisms have been related with hypertension but with contradictory results between populations. We have investigated the association among the allelic distribution of the insertion-deletion (I/D) polymorphism of the ACE gene, identified by polymerase chain reaction (PCR), serum ACE activity determined by spectrophotometry, and the blood pressure (BP), in a Mediterranean population in the southwest of Europe. A total of 1322 randomised individuals were analysed, and a comparative study was conducted analysing 205 indi-

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme (ACE) gene polymorphisms, serum ACE activity and blood pressure in a Spanish-Mediterranean population

et al. 2000

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“…Genotyping of the ACE gene I/D polymorphism was performed as described previously. 33,34 Genotyping of the AT 1 R gene A1166C polymorphism was performed with the PCR restriction fragmentlength polymorphism method. 35 For genotyping of AGT gene polymorphisms, we used mini-PCR direct sequencing as described previously.…”

Section: Identification Of Diallelic Polymorphismsmentioning

confidence: 99%

Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation

et al. 2004

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Background-The activated local atrial renin-angiotensin system (RAS) has been reported to play an important role in the pathogenesis of atrial fibrillation (AF). We hypothesized that RAS genes might be among the susceptibility genes of nonfamilial structural AF and conducted a genetic case-control study to demonstrate this. Methods and Results-A total of 250 patients with documented nonfamilial structural AF and 250 controls were selected.The controls were matched to cases on a 1-to-1 basis with regard to age, gender, presence of left ventricular dysfunction, and presence of significant valvular heart disease. The ACE gene insertion/deletion polymorphism, the T174M, M235T, G-6A, A-20C, G-152A, and G-217A polymorphisms of the angiotensinogen gene, and the A1166C polymorphism of the angiotensin II type I receptor gene were genotyped. In multilocus haplotype analysis, the angiotensinogen gene haplotype profile was significantly different between cases and controls ( 2 ϭ62.5, Pϭ0.0002). In single-locus analysis, M235T, G-6A, and G-217A were significantly associated with AF. Frequencies of the M235, G-6, and G-217 alleles were significantly higher in cases than in controls (Pϭ0.000, 0.005, and 0.002, respectively). The odds ratios for AF were 2.5 (95% CI 1.7 to 3.3) with M235/M235 plus M235/T235 genotype, 3.3 (95% CI 1.3 to 10.0) with G-6/G-6 genotype, and 2.0 (95% CI 1.3 to 2.5) with G-217/G-217 genotype. Furthermore, significant gene-gene interactions were detected by the multifactor-dimensionality reduction method and multilocus linkage disequilibrium tests. Conclusions-This study demonstrates the association of RAS gene polymorphisms with nonfamilial structural AF and may provide the rationale for clinical trials to investigate the use of ACE inhibitor or angiotensin II antagonist in the treatment of structural AF.

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“…Individuals with the I/D polymorphism showed an association with EH in different areas in Japan, 15 but another reports on ACE I/D polymorphism did not appear to have any significant association with variations in BP in Chinese and other Japanese groups. 16,17 Several studies have demonstrated significant age-related associations between ACE I/D polymorphisms and hypertension in gender-specific analyses among different populations, among whom there is association and genetic linkage of the ACE I/D polymorphism with hypertension for males but not for females. 9,18 The DD genotypes were less common in elderly hypertensive Caucasians than in age-matched normotensive subjects.…”

Section: Introductionmentioning

confidence: 99%

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

et al. 2006

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Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein b3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P ¼ 0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (Po0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P ¼ 0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

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Lack of association of the angiotensin converting enzyme gene polymorphism with essential hypertension in a chinese population

Cited by 58 publications

References 23 publications

Angiotensin-converting enzyme (ACE) gene polymorphisms, serum ACE activity and blood pressure in a Spanish-Mediterranean population

Angiotensin-converting enzyme (ACE) gene polymorphisms, serum ACE activity and blood pressure in a Spanish-Mediterranean population

Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

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