Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects

Zhuo, Xianlu; Ling, Junjun; Zhao, Hou-Yu; Zhou, Yan; Song, Yijun; Tan, Yinghui

doi:10.3892/etm.2012.648

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Analogous to these results, Dancau et al found no correlation between survival and CCND1 or PPFIA1/ CCND1 amplification in breast cancer patients (Dancau et al, 2010). The molecular role of PPFIA1 and CCND1 regarding its expression behaviour are still subjects of research (Zhuo et al, 2012). The influence of the PPFIA1 amplification on the PPFIA1 expression could not be examined in this study due to lack of adequate antibodies.…”

Section: Discussionmentioning

confidence: 59%

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)

Blessmann

Al‐Dam

Hanken

et al. 2013

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 59%

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)

Blessmann

Al‐Dam

Hanken

et al. 2013

Journal of Cranio-Maxillofacial Surgery

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“…However, the results remain inconsistent and controversial, partially due to the relatively small sample size of independent studies and sampling effects. Meta-analysis allow stronger conclusions for identifying certain models of risk markers, which may aid in screening, early diagnosis and/or therapy in the clinic (19,20). To the best of our knowledge, no previous meta-analysis has focused on the XPA A23G polymorphism and HNSCC risk.…”

Section: Introductionmentioning

confidence: 99%

Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects

Gao

et al. 2015

Molecular and Clinical Oncology

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Abstract. The XPA gene participates in modulating DNA damage recognition during the DNA nucleotide excision repair process. Current data regarding the association of the XPA A23G polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) remain controversial, and meta-analyses focusing on the HNSCC risk and this polymorphism are limited. Therefore, the aim of the present study was to derive a more precise estimation of this association by a meta-analysis of all the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CI) were assessed for the strength of the associations in eight studies, including 5,491 subjects (2,409 HNSCC cases and 3,082 controls). The overall analysis revealed that the XPA A23G polymorphism was not significantly associated with the overall HNSCC risk. Consistently, there was no evidence for the association between the XPA A23G polymorphism and HNSCC risk in subgroup analyses based on ethnicity and the source of controls. However, the significant associations in oral carcinoma with the increased risk among the XPA heterozygote (AG vs. AA: OR, 1.58; 95% CI, 1.06-2.37; P heterogeneity =0.23, I2 =30%) and dominant (AG +GG vs. AA: OR, 1.53; 95% CI, 1.04-2.23; P heterogeneity =0.21, I 2 =36%) models were observed in the subgroup analysis by tumor site. In conclusion, the meta-analysis suggested that the XPA A23G polymorphism was not associated with overall HNSCC susceptibility, but it was associated with oral carcinoma susceptibility and it may be a risk factor for oral carcinoma. Further well-designed and large studies are required to confirm these associations.

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Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis

Wang

Gao

et al. 2013

Tumor Biol.

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Data from several case-control studies on the relation between the Cyclin D1 (CCND1) G870A polymorphism and oral cancer susceptibility implicated conflicting conclusions. Thus, a meta-analysis was performed to derive a more precise evaluation of the association. We searched PubMed and Embase for related studies that had been published in English and eight available studies were finally included in the meta-analysis. Odd ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each study. Our meta-analysis suggested that CCND1 G870A polymorphism was not associated with oral cancer risk (OR AA vs. GG = 1.08, 95 % CI = 0.90-1.30, P heterogeneity = 0.175; OR AA + GA vs. GG = 1.02, 95 % CI = 0.91-1.14, P heterogeneity = 0.781; OR AA vs. GA + GG = 1.16, 95 % CI = 0.98-1.36, P heterogeneity = 0.107; OR A vs. G = 1.05 95 % CI = 0.96-1.15, P heterogeneity = 0.211; OR GA vs. GG = 0.94, 95 % CI = 0.82-1.08, P heterogeneity = 0.935). However, in the subgroup analysis by ethnicity, possible significance among Asian groups was indicated in two genetic models (OR AA vs. GA + GG = 1.27, 95 % CI = 1.05-1.54, P heterogeneity = 0.572; OR allele A vs. allele G = 1.11, 95 % CI = 1.00-1.24, P heterogeneity = 0.211). Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.

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Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects

Cited by 3 publications

References 38 publications

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)

Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects

Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis

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