Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer

Mahmoudi, Touraj; Karimi, Khatoon; Arkani, Maral; Farahani, Hamid; Nobakht, Hossein; Dabiri, Reza; Asadi, Asadollah; Vahedi, Mohsen; Zali, Mohammad Reza

doi:10.7314/apjcp.2014.15.2.957

Cited by 17 publications

(13 citation statements)

References 21 publications

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“…However, other studies have found more inconsistent results (Poynter et al, 2010;Mahmoudi et al, 2014). Inverse relationship between serum vitamin D level and colorectal cancer risk has been demonstrated by a recent study .…”

Section: Discussionmentioning

confidence: 92%

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay¹,

Boonpipattanapong²,

Kanngurn³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients. Materials and Methods: Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs. Results: The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minorallele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective

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Section: Discussionmentioning

confidence: 92%

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay¹,

Boonpipattanapong²,

Kanngurn³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Three studies showed no associations between SNPs in these genes and overall risk for colorectal cancer (27, 29, 30), while another report demonstrated a nominal relationship between the CYP24A1 polymorphism rs4809958 and risk for colon cancer (28). In the present study, no association between rs4809958 and overall adenoma recurrence, nor any adenoma characteristic, was observed, which is consistent with the majority of the published literature for colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

CYP24A1andCYP27B1Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Hibler

Klimentidis

Jurutka

et al. 2015

Nutrition and Cancer

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Development of colorectal adenoma and cancer are associated with low circulating 25-hydroxyvitamin D (25(OH)D) levels. However, less is known regarding colorectal neoplasia risk and variation in CYP27B1 or CYP24A1, genes encoding the enzymes responsible for the synthesis and catabolism of 1α,25-hydroxyvitamin D (1,25(OH)2D). This study examined associations between CYP27B1 and CYP24A1 polymorphisms, circulating 25(OH)D and 1,25(OH)2D concentrations, and colorectal adenoma recurrence in a pooled sample from two clinical trials (n=1,188). Nominal associations were observed between increasing copies of the T allele in CYP24A1 rs927650 and 25(OH)D concentrations (p=0.02); as well as colorectal adenoma recurrence, with ORs (95% CIs) of 1.30 (0.99–1.70) and 1.38 (1.01–1.89) for heterozygotes and minor allele homozygotes, respectively (p=0.04). In addition, a statistically significant relationship between CYP24A1 rs35051736, a functional polymorphism, and odds for advanced colorectal adenoma recurrence was observed (p<0.001). Further, nominally statistically significant interactions were observed between rs2296241 and 25(OH)D as well as rs2762939 and 1,25(OH)2D (pinteraction = 0.10, respectively). Overall, CYP24A1 polymorphisms may influence the development of advanced lesions, and modify the effect of vitamin D metabolites on adenoma recurrence. Further study is necessary to characterize the differences between circulating vitamin D metabolite measurements compared to cellular level activity in relation to cancer risk.

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“…However, our results were not consistent with several meta-analysis about VDR BsmI polymorphism and other cancer risk. For instance, Mahmoudi et al (2014) recently found that Vitamin D Metabolism -Related Gene (including VDR) Variants was not associated with Risk of Colorectal Cancer in Iranian population. In recent, Zhang et al (2013) performed a meta-analysis to detect VDR BsmI polymorphism and ovarian cancer risk and found that there was no association between VDR BsmI polymorphism and susceptibility to ovarian cancer in Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis

Yu¹,

Yang²,

Jiang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Similarly, a decreased CRC risk was also found in the dominant and recessive models. When stratifying for ethnicity, source of controls, and study sample size, associations were observed among Caucasians, population-based studies and studies with large study sample size (>1000 subjects). Limiting the analysis to the studies within Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study. Conclusions: This updated meta-analysis suggests that the VDR BsmI polymorphism may be associated with a moderate protective effect against CRC.

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Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer

Cited by 17 publications

References 21 publications

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

CYP24A1andCYP27B1Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis

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