Lack of Behavioral Supersensitivity to d-Amphetamine After Pimozide Withdrawal

Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal‐related relapse

“…However, the association with psychosis has been little investigated in humans or animals. One small study with 12 schizophrenic patients did not show increased psychotic symptoms with amphetamine administration after pimozide withdrawal compared with amphetamine administration in a previous drug‐free state, although this drug‐free state was only 3–7 weeks after withdrawal of previous antipsychotic treatment (39). In addition, proposed associations with other presumed manifestations of dopamine supersensitivity such as tardive dyskinesia and prolactin elevation have not been consistently demonstrated (4, 24).…”