Lack of Carcinogenicity of Sodium Metaphosphate in Fischer 344 Rats.

Kitahori, Yoshiteru; Konishi, Noboru; Cho, Masaki; Yamamoto, K; Nakagawa, Yasuaki; Matsui, Emi; Hiasa, Yoshio

doi:10.1293/tox.11.41

Cited by 1 publication

(2 citation statements)

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“…The carcinogenicity of sodium metaphosphate (corresponding to soluble sodium polyphosphate) was investigated in F344 rats (50 animals/sex per dose; 6 weeks old) (Kitahori et al, 1998). Sodium metaphosphate was administered in the diet at concentrations of 1.5% or 3.0%.…”

Section: Polyphosphates Ratmentioning

confidence: 99%

“…The key adverse effects in these three life time studies as well as in two chronic toxicity studies of 6 months duration were calcification in the kidneys and tubular nephropathy. The lowest tested level of phosphate causing an effect in the kidney was approximatively 750 mg/kg bw (corresponding to 229 mg P/kg bw per day) in a 2-year study with sodium metaphosphate (Kitahori et al, 1998). Two reliable NOAELs could be identified, 250 mg/kg bw per day (corresponding to 63 mg/kg P bw per day) and 250 mg/kg bw per day (corresponding to 76 mg/kg P bw per day) with sodium triphosphate and sodium hexametaphosphate, respectively (Hodge, 1959(Hodge, , 1960.…”

Section: Polyphosphates Ratmentioning

confidence: 99%

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Re‐evaluation of phosphoric acid–phosphates – di‐, tri‐ and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use

Flavourings¹,

Younes²,

Aquilina³

et al. 2019

EFS2

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The Panel on Food Additives and Flavourings added to Food (FAF) provided a scientific opinion re-evaluating the safety of phosphates (E 338-341, E 343, E 450-452) as food additives. The Panel considered that adequate exposure and toxicity data were available. Phosphates are authorised food additives in the EU in accordance with Annex II and III to Regulation (EC) No 1333/2008. Exposure to phosphates from the whole diet was estimated using mainly analytical data. The values ranged from 251 mg P/person per day in infants to 1,625 mg P/person per day for adults, and the high exposure (95th percentile) from 331 mg P/person per day in infants to 2,728 mg P/person per day for adults. Phosphate is essential for all living organisms, is absorbed at 80-90% as free orthophosphate excreted via the kidney. The Panel considered phosphates to be of low acute oral toxicity and there is no concern with respect to genotoxicity and carcinogenicity. No effects were reported in developmental toxicity studies. The Panel derived a group acceptable daily intake (ADI) for phosphates expressed as phosphorus of 40 mg/kg body weight (bw) per day and concluded that this ADI is protective for the human population. The Panel noted that in the estimated exposure scenario based on analytical data exposure estimates exceeded the proposed ADI for infants, toddlers and other children at the mean level, and for infants, toddlers, children and adolescents at the 95th percentile. The Panel also noted that phosphates exposure by food supplements exceeds the proposed ADI. The Panel concluded that the available data did not give rise to safety concerns in infants below 16 weeks of age consuming formula and food for medical purposes.

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Section: Polyphosphates Ratmentioning

confidence: 99%

Section: Polyphosphates Ratmentioning

confidence: 99%