1990
DOI: 10.1097/00002826-199002000-00005
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Lack of Cardiovascular Side Effects of the New Tricyclic Antidepressant Tianeptine A Double-Blind, Placebo-Controlled Study in Young Healthy Volunteers

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Cited by 12 publications
(4 citation statements)
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“…1 Tianeptine causes less cardiac toxicity than classical TCAs. 2 It has been reported that TCA-related fatalities commonly are associated with ingestions of greater than 1 g. 3 These data may explain why cardiac arrest has not occured in this patient. Respiratory arrest and coma may be caused by the co-ingestion of amitriptyline with tianeptine.…”
Section: Discussionmentioning
confidence: 53%
“…1 Tianeptine causes less cardiac toxicity than classical TCAs. 2 It has been reported that TCA-related fatalities commonly are associated with ingestions of greater than 1 g. 3 These data may explain why cardiac arrest has not occured in this patient. Respiratory arrest and coma may be caused by the co-ingestion of amitriptyline with tianeptine.…”
Section: Discussionmentioning
confidence: 53%
“…Though tianeptine is structurally similar to tricyclic antidepressants (TCAs), reports of TCA-like toxicity are lacking. Volunteer studies and several case series of acute tianeptine ingestions have been published, none of which show TCA-like toxicity [16] , [17] , [18] . Additionally, tianeptine has full μ-opioid and ∂-opioid receptor agonist properties.…”
Section: Discussionmentioning
confidence: 99%
“…In zwei Studien (30,38) wurde die kardiovaskuläre Verträglichkeit speziell mit einem für Tianeptin günstigen Ergebnis (u.a. keine EKG-Veränderungen) untersucht.…”
Section: Pharmakotherapeutisches Satellitenforumunclassified