Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma

Melchers, Lieuwe J.; Bruin, Leonie Bruine de; Schnell, Ulrike; Slagter‐Menkema, Lorian; Mastik, Mirjam F.; Bock, de Truuske; Dijk, van Boukje; Giepmans, Ben N. G.; Laan, van der Bernard; Wal, Jacqueline E. van der; Roodenburg, Jan; Schuuring, Ed

doi:10.1016/j.oraloncology.2013.07.008

Cited by 31 publications

(29 citation statements)

References 54 publications

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“…Heterogeneity of molecular expression within individual tumors and between the primary and metastatic tumors has been reported in some types of cancers (Jacobsen et al 2013;Kroepil et al 2013;Melchers et al 2013). In gastric cancer, differential epithelial cell adhesion molecule (EpCAM) expression between the center and the invasive front of the tumor has been reported, and high EpCAM expression in the invasive front, but not that in the center of the tumor, has been reported as a poor prognostic factor (Kroepil et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Udagawa

Ishii

Morise

et al. 2015

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Udagawa

Ishii

Morise

et al. 2015

J Cancer Res Clin Oncol

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“…A handful of studies examined the changes in claudin expression in OSCC [25][26][27][28][29][30][31]. The potential role of claudin-1 in promoting the growth and invasion of OSCC cells was reported [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma

Sappayatosok

Phattarataratip

2014

Head and Neck Pathol

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Claudins constitute a group of principal proteins forming the tight junctional complex. The altered expression of selected claudins has been reported in several human cancers. The purpose of this study was to investigate the expression of claudin-1 and claudin-4 in oral squamous cell carcinoma (OSCC) and examine its relationship with patient clinical-pathologic features. Fortyfive OSCC cases were enrolled. Patient clinical, pathologic and follow-up data were reviewed and the claudin-1 and claudin-4 expression was analyzed immunohistochemically. Positive claudin-1 and claudin-4 immunoreactivities were noted in 86.7 and 80 % of cases, respectively. The majority of cases showed the staining in less than 25 % of cancer cells. The increased claudin-1 expression was significantly associated with the high pathologic grade, the presence of microscopic perineural invasion, vascular invasion, nodal metastasis, and advanced clinical stage. No relationship between various clinico-pathologic parameters and differential claudin-4 expression was observed.Claudin-1 may play a role in OSCC progression and could serve as a prognostic marker of advanced disease.

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“…Melchers et al [37] performed an immunohistochemical study in 208 patients with oral cavity or oropharynx carcinomas treated with surgery. They found that expression of claudin-7, a protein involved in the formation of tight junctions between epithelial cells, was related to a significant decrease in the risk of regional recurrence.…”

Section: Discussionmentioning

confidence: 99%

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

León

Diez

García

et al. 2016

Eur Arch Otorhinolaryngol

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Expression of the CXCL12/CXCR4 chemokine axis has been related with the appearance of metastatic recurrence survival, including regional and distant recurrence, in patients with head and neck squamous cell carcinoma (HNSCC). RT-PCR was used to determine mRNA expression levels of CXCL12 and CXCR4 in biopsy tumor samples in 111 patients with HNSCC. Five-year regional recurrence-free survival for patients with low CXCR4 expression (n = 39, 31.5 %) was 97.4 %, for patients with high CXCR4/high CXCL12 expression (n = 22, 19.8 %) it was 94.7 %, and for patients with high CXCR4/low CXCL12 expression (n = 50, 45.0 %) it was 63.3 %. We found significant differences in the regional recurrence-free survival according to CXCR4/CXCL12 expression values (P = 0.001). HNSCC patients with high CXCR4 and low CXCL12 expression values had a significantly higher risk of regional recurrence and could benefit from a more intense treatment of lymph node areas in the neck.

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Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma

Cited by 31 publications

References 54 publications

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

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