Lack of concordance between reporting guidelines and risk of bias assessments of preclinical studies; a call for integrated recommendations

Ahmadzadeh, Koohyar; Dizaji, Shayan Roshdi; Yousefifard, Mahmoud

doi:10.1097/js9.0000000000000475

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…We considered the level of evidence for our included preclinical articles to be moderate, due to serious risks of bias. Conversely, it is recently argued that the current guidelines for the evaluation of the risk of bias in preclinical studies are not in compliance with the guidelines on how to conduct them; therefore, the risk of bias could be overestimated due to the lack of reporting in some domains of risk of bias assessment, simply because the authors did not document them in their manuscripts [ 72 ]. Since our results demonstrated an acceptable efficacy for exercise in the management of neuropathic pain, we prominently recommend further clinical research with robust methodologies in this field.…”

Section: Discussionmentioning

confidence: 99%

The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

Toloui,

Ramawad,

Gharin

et al. 2023

Neurospine

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Objective: The objective of this systematic review and meta-analysis was to assess the efficacy of exercise in neuropathic pain following traumatic spinal cord injuries.Methods: The search was conducted in MEDLINE, Embase, Scopus, and Web of Science by the end of 2022. Two independent researchers included the articles based on the inclusion and exclusion criteria. A standardized mean difference was calculated for each data and they were pooled to calculate an overall effect size. To assess the heterogeneity between studies, I<sup>2</sup> and chi-square tests were utilized. In the case of heterogeneity, meta-regression was performed to identify the potential source.Results: Fifteen preclinical studies were included. Meta-analysis demonstrated that exercise significantly improves mechanical allodynia (standardized mean difference [SMD], -1.59; 95% confidence interval [CI], -2.16 to -1.02; p < 0.001; I<sup>2</sup> = 90.37%), thermal hyperalgesia (SMD, 1.95; 95% CI, 0.96–2.94; p < 0.001), and cold allodynia (SMD, -2.92; 95% CI, -4.4 to -1.43; p < 0.001). The improvement in mechanical allodynia is significantly more in animals with a compression model of SCI (meta-regression coefficient, -1.33; 95% CI, -1.84 to -0.57; p < 0.001) and in mild SCI (p < 0.001). Additionally, the improvement was more prominent if the training was started 7 to 8 days postinjury (coefficient, -2.54; 95% CI, -3.85 to -1.23; p < 0.001) and was continued every day (coefficient, -1.99; 95% CI, -3.07 to -0.9; p < 0.001). Likewise, voluntary exercise demonstrated a significantly more effect size (coefficient, -1.45; 95% CI, -2.67 to -0.23; p = 0.02).Conclusion: Exercise is effective in the amelioration of neuropathic pain. This effect in mechanical allodynia is more prominent if voluntary, continuous training is initiated in the subacute phase of mild SCI.

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Section: Discussionmentioning

confidence: 99%

The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

Toloui,

Ramawad,

Gharin

et al. 2023

Neurospine

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“…Also, it has recently been argued that due to the lack of concordance between guidelines for conducting preclinical studies and guidelines for their quality assessment, some domains might be at high risk of bias, solely due to the fact that the authors did not document them in their articles, even though those recommendations might have been followed during the experiment [ 56 ]. The overall level of evidence was downrated only due to the serious risk of bias.…”

Section: Discussionmentioning

confidence: 99%

Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies

Ramawad,

Paridari,

Jabermoradi

et al. 2023

Korean J Pain

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Background Muscimol’s quick onset and GABAergic properties make it a promising candidate for the treatment of pain. This systematic review and meta-analysis of preclinical studies aimed at summarizing the evidence regarding the efficacy of muscimol administration in the amelioration of nerve injury-related neuropathic pain. Methods Two independent researchers performed the screening process in Medline, Embase, Scopus and Web of Science extracting data were extracted into a checklist designed according to the PRISMA guideline. A standardized mean difference (SMD [95% confidence interval]) was calculated for each. To assess the heterogeneity between studies, I 2 and chi-square tests were utilized. In the case of heterogeneity, meta-regression and subgroup analyses were performed to identify the potential source. Results Twenty-two articles met the inclusion criteria. Pooled data analysis showed that the administration of muscimol during the peak effect causes a significant reduction in mechanical allodynia (SMD = 1.78 [1.45–2.11]; P < 0.0001; I 2 = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28–1.96]; P < 0.0001; I 2 = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79–3.39]; P < 0.0001; I 2 = 80.33%). This significant amendment of pain was observed at a declining rate from 15 minutes to at least 180 minutes post-treatment in mechanical allodynia and mechanical hyperalgesia, and up to 30 minutes in thermal hyperalgesia ( P < 0 .0001). Conclusions Muscimol is effective in the amelioration of mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia, exerting its analgesic effects 15 minutes after administration for up to at least 3 hours.

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Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

Haeri Moghaddam,

Hashamdar,

Hamblin

et al. 2024

World Neurosurgery

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Lack of concordance between reporting guidelines and risk of bias assessments of preclinical studies; a call for integrated recommendations

Cited by 3 publications

References 5 publications

The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies

Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

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