Lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [18F]fallypride PET

Smith, Christopher T.; Dang, Linh C.; Burgess, Leah; Perkins, Scott F.; Juan, M. Danica San; Smith, Darcy; Cowan, Ronald L.; Le, Nam T.; Kessler, Robert; Samanez-Larkin, Gregory R.; Zald, David H.

doi:10.1007/s00213-018-5083-5

Cited by 19 publications

(18 citation statements)

References 56 publications

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“…Sample size range was 8-55 in both HC groups and female control groups. Age span was 16-45 years, except in three studies (Vincent et al, 2013;De Bondt et al, 2015b;Smith et al, 2018) which provided no information about age, and four studies where only mean age was provided Hwang et al, 2015;Scheele et al, 2016;Smith et al, 2018;Hornung et al, 2019). One study (Mareckova et al, 2014) additionally assessed an adolescent sample aged 13.5-15.5 years with 55 participants in both the HC and the NC control group.…”

Section: Summary Of Functional Studiesmentioning

confidence: 99%

“…A final study of motivational effects of HC was conducted by Smith et al (2018) who performed a PET study to assess sex differences in dopamine release in inferior frontal areas as well as the dorsal and ventral striatum. They administered D-amphetamine to NC and HC women, as well as to men, to elucidate possible sexually dimorphic neural and hormonal contributions to addiction.…”

Section: Reward and Motivationmentioning

confidence: 99%

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The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

et al. 2020

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Background: Hormonal contraceptive drugs are being used by adult and adolescent women all over the world. Convergent evidence from animal research indicates that contraceptive substances can alter both structure and function of the brain, yet such effects are not part of the public discourse or clinical decision-making concerning these drugs. We thus conducted a systematic review of the neuroimaging literature to assess the current evidence of hormonal contraceptive influence on the human brain. Methods: The review was registered in PROSPERO and conducted in accordance with the PRISMA criteria for systematic reviews. Structural and functional neuroimaging studies concerning the use of hormonal contraceptives, indexed in Embase, PubMed and/or PsycINFO until February 2020 were included, following a comprehensive and systematic search based on predetermined selection criteria. Results: A total of 33 articles met the inclusion criteria. Ten of these were structural studies, while 23 were functional investigations. Only one study investigated effects on an adolescent sample. The quality of the articles varied as many had methodological challenges as well as partially unfounded theoretical claims. However, most of the included neuroimaging studies found functional and/or structural brain changes associated with the use of hormonal contraceptives. Conclusion: The included studies identified structural and functional changes in areas involved in affective and cognitive processing, such as the amygdala, hippocampus, prefrontal cortex and cingulate gyrus. However, only one study reported primary research on a purely adolescent sample. Thus, there is a need for further investigation of the implications of these findings, especially with regard to adolescent girls.

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Section: Summary Of Functional Studiesmentioning

confidence: 99%

Section: Reward and Motivationmentioning

confidence: 99%

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

et al. 2020

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“… 20 , 21 The latter has also been confirmed in rodent studies, 22 , 23 but in humans this may only be present in young adults. 24 Nevertheless, differences in reward-specific dopamine release between women and men have not yet been investigated, which is potentially attributable to the methodological difficulties mentioned above. Consequently, the neuronal underpinnings of behavioral sex differences in reward and punishment processing remain largely unknown, particularly because fMRI studies of the MID 1 , 25 or other reward paradigms 26 , 27 were unable to show any sex differences during reward consumption.…”

Section: Introductionmentioning

confidence: 99%

Functional dynamics of dopamine synthesis during monetary reward and punishment processing

Hahn

Reed

Pichler

et al. 2021

J Cereb Blood Flow Metab

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The assessment of dopamine release with the PET competition model is thoroughly validated but entails disadvantages for the investigation of cognitive processes. We introduce a novel approach incorporating 6-[18F]FDOPA uptake as index of the dynamic regulation of dopamine synthesis enzymes by neuronal firing. The feasibility of this approach is demonstrated by assessing widely described sex differences in dopamine neurotransmission. Reward processing was behaviorally investigated in 36 healthy participants, of whom 16 completed fPET and fMRI during the monetary incentive delay task. A single 50 min fPET acquisition with 6-[18F]FDOPA served to quantify task-specific changes in dopamine synthesis. In men monetary gain induced stronger increases in ventral striatum dopamine synthesis than loss. Interestingly, the opposite effect was discovered in women. These changes were further associated with reward (men) and punishment sensitivity (women). As expected, fMRI showed robust task-specific neuronal activation but no sex difference. Our findings provide a neurobiological basis for known behavioral sex differences in reward and punishment processing, with important implications in psychiatric disorders showing sex-specific prevalence, altered reward processing and dopamine signaling. The high temporal resolution and magnitude of task-specific changes make fPET a promising tool to investigate functional neurotransmitter dynamics during cognitive processing and in brain disorders.

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“…Interestingly, none of these studies considered sex-differences in task-induced dopamine release, despite numerous reports of general differences between men and women regarding ventral tegmental area functioning [22], dopamine synthesis rates at baseline [23] and amphetamine-induced release [24,25] (but see [26]).…”

Section: Introductionmentioning

confidence: 99%

Functional dynamics of dopamine synthesis during monetary reward and punishment processing

Hahn

Reed

Pichler

et al. 2019

Preprint

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Women and men show different behavioral sensitivity to reward and punishment, however, in humans the underlying neurotransmitter action has not yet been identified. Based on functional PET, we introduce a novel approach to enable the investigation of rapid changes in dopamine neurotransmission during cognitive task performance. In men, monetary gain induced 78% increase in dopamine synthesis vs. 49% for loss, whereas women showed the reverse pattern. Behavioral modeling revealed a direct association of task-specific dopamine synthesis with reward sensitivity in men and punishment sensitivity in women. Since dopaminergic sex differences were not reflected in BOLD signal changes, we emphasize a careful interpretation of fMRI-based studies on reward. This may have important implications in psychiatric conditions with sex-specific prevalence rates, alterations in reward processing and dopamine signaling. The high temporal resolution and magnitude of task-specific changes make fPET a promising tool to investigate such neurotransmitter dynamics in health and disease.

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Lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [18F]fallypride PET

Cited by 19 publications

References 56 publications

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

Functional dynamics of dopamine synthesis during monetary reward and punishment processing

Functional dynamics of dopamine synthesis during monetary reward and punishment processing

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