Lack of correlation between coronary blood flow and carotid intima media thickness

Arbel, Yaron; Szekely, Yishay; Berliner, Shlomo; Hallevi, Hen; Halkin, Amir; Herz, Itzhak; Keren, Gad; Bazan, Shmuel; Bornstein, Natan M.; Banai, Shmuel; Finkelstein, Ariel

doi:10.3233/ch-141808

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…The phenomenon of SCF in the presence of normal coronary arteries may indicate endothelial dysfunction, which is characteristic of an early stage in the development of atherosclerosis. Despite this association, such patients do not have increased carotid IMT values ( 50 ). In line with our results stands a study by Tabara et al including 1,978 participants from two independent cohorts, which showed that hematocrit was positively associated with insulin resistance and insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study

et al. 2018

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BackgroundLiterature data suggest with some criticism that full-fledged cardiovascular (CV) events (acute or chronic) are likely predicted by blood components, which are reported to be associated with the presence/severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed at determining which marker(s) derived from blood count, such as white blood cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD.MethodsOne hundred consecutive obese patients presenting NAFLD at ultrasound, with low prevalence of co-morbidities and no history or instrumental features of CV diseases, underwent carotid intima-media thickness (IMT) assessment by Doppler ultrasonography. All of them were studied taking into account anthropometric parameters, the metabolic profile, and inflammatory markers.ResultsWhite blood cells and neutrophil count showed no statistical association with IMT, which was predicted by the amount of visceral adiposity, as appreciated by ultrasonography. After adjusting for visceral adiposity and smoking status, only age and hematocrit contextually predicted early atherosclerosis, evaluated as IMT. Visceral adiposity was a confounding factor in foreseeing IMT.ConclusionHematocrit values along with the patient’s age suggest an initial atherosclerosis, evaluated as IMT, and if this finding is confirmed in larger cohorts, could be added to other canonical CV risk factors. Inferences can be enhanced by future prospective studies that aim to identify the relationships between incident cardio-metabolic cases and this hematologic parameter.

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Section: Discussionmentioning

confidence: 99%

Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study

et al. 2018

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Relation of Metabolic Syndrome With Long-Term Mortality in Acute and Stable Coronary Disease

Arbel

Havakuk

Halkin

et al. 2015

The American Journal of Cardiology

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HbA<sub>1c</sub> Levels and Long-Term Mortality in Patients Undergoing Coronary Angiography

et al. 2016

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Objectives: Previous studies investigating the prognostic value of HbA_1c in patients undergoing coronary angiography reported a mixed pattern of results. Therefore, we aimed to better define the prognostic power of HbA_1c among coronary catheterized patients. Methods: Patients undergoing coronary angiography (n = 3,749) were divided into four groups according to HbA_1c levels (<5, 5-6, 6-7 and >7%). Cox regression models assessed long-term mortality after adjusting for multiple covariates. Results: Baseline clinical profiles differed in HbA_1c groups, with a higher prevalence of comorbidities in the groups with higher HbA_1c levels. Median follow-up was 1,745 days (interquartile range 1,007-2,171). A J-shaped association curve was observed between HbA_1c levels and all-cause mortality rates, with patients in the lowest and highest HbA_1c groups suffering from significantly higher mortality rates compared to in-between groups (hazard ratio 1.9, 95% CI 1.32-2.74, p = 0.001, and hazard ratio 1.58, 95% CI 1.29-1.95, p < 0.001, for the lowest and highest HbA_1c groups, respectively). This association persisted after adjustment for anemia, nutritional status, renal function, cardiovascular risk factors and inflammatory biomarkers. Conclusions: HbA_1c levels <5 or >7% are predictors of all-cause mortality in patients undergoing coronary angiography.

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Lack of correlation between coronary blood flow and carotid intima media thickness

Cited by 6 publications

References 22 publications

Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study

Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study

Relation of Metabolic Syndrome With Long-Term Mortality in Acute and Stable Coronary Disease

HbA<sub>1c</sub> Levels and Long-Term Mortality in Patients Undergoing Coronary Angiography

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