Lack of correlation between exposure to lyme disease (Borrelia burgdorferi) and pregnancy loss in mares

Eisner, Robert J.; Meirs, David; Ralston, Sarah L.

doi:10.1016/s0737-0806(06)81885-x

Cited by 5 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, some adverse birth outcomes have been recorded for white-footed mice, dogs, cattle, horses, and a coyote. The most common outcomes were reproductive failure (inability to conceive) and fetal loss during pregnancy [ 9 – 16 ]. Animal model experiments identified B .…”

Section: Introductionmentioning

confidence: 99%

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

et al. 2018

View full text Add to dashboard Cite

Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Data were summarized descriptively and random effects meta-analysis (MA) was used where appropriate. The SR identified 45 relevant studies, 29 describing 59 cases reported as gestational LD in the United States, Europe, and Asia (1969–2017). Adverse birth outcomes included spontaneous miscarriage or fetal death (n = 12), newborn death (n = 8), and newborns with an abnormal outcome (e.g. hyperbilirubinemia, respiratory distress and syndactyly) at birth (n = 16). Only one report provided a full case description (clinical manifestations in the mother, negative outcome for the child, and laboratory detection of B. burgdorferi in the child) that provides some evidence for vertical transmission of B. burgdorferi that has negative consequences for the fetus. The results of 17 epidemiological studies are included in this SR. Prevalence of adverse birth outcomes in an exposed population (defined by the authors as: gestational LD, history of LD, tick bites or residence in an endemic area) was compared to that in an unexposed population in eight studies and no difference was reported. A meta-analysis of nine studies showed significantly fewer adverse birth outcomes in women reported to have been treated for gestational LD (11%, 95%CI 7–16) compared to those who were not treated during pregnancy (50%, 95%CI 30–70) providing indirect evidence of an association between gestational LD and adverse birth outcomes. Other risk factors investigated; trimester of exposure, length of LD during pregnancy, acute vs. disseminated LD at diagnosis, and symptomatic LD vs. seropositive women with no LD symptoms during pregnancy were not significantly associated with adverse birth outcomes. This SR summarizes evidence from case studies that provide some limited evidence for transplacental transmission of B. burgdorferi. There was inconsistent evidence for adverse birth outcomes of gestational LD in the epidemiological research, and uncommon adverse outcomes for the fetus may occur as a consequence of gestational LD. The global evidence does not fully characterize the potential impact of gestational LD, and future research that addresses the knowledge gaps may change the findings in this SR. Given the current evidence; prompt diagnosis and treatment of LD during pregnancy is recommended.

show abstract

Section: Introductionmentioning

confidence: 99%

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Gross fetal changes ranged from an absence of lesions to an enlarged jaundiced liver, perirenal edema, radiating white streaks in the kidney, and placentitis. 43,44 Potomac horse fever (Ehrlichia risticii) has been associated with abortion. Infected foals may be stillborn or born jaundiced, presumably after in utero leptospiral infection.…”

Section: Bacterial Diseasesmentioning

confidence: 99%

Infectious Diseases of the Puerperal Period

Card¹,

Lopate²

2007

Current Therapy in Large Animal Theriogenology

View full text Add to dashboard Cite

“…However, silver stains are non-specific and difficult to interpret (1), culture for B. burgdorferi in blood, synovial-and anterior chamber fluid was negative and no Borrelia antibodies were detected in the anterior chamber fluid. Even early pregnancy failure in horses has been associated , with B. burgdorferi but not proven by Sorensen et al (88), but was considered without significant correlation in a study by Eisner et al (34) Despite the high antibody titers to B. burgdorferi in these ponies however, the spirochete could still be isolated from various post-mortem tissues, which indicates that persistent infection can be established in clinically healthy horses (23).…”

Section: Borrelia Burgdorferi Infection In Horsesmentioning

confidence: 99%

Borrelia burgdorferiinfections with special reference to horses. A review

Butler¹,

Houwers

Jongejan

et al. 2005

Veterinary Quarterly

View full text Add to dashboard Cite

Summary This review discusses the literature on B. burgdorferi infections in view of the rising incidence of this infection in general and the increasing concerns of horse owners and equine practitioners. Lyme disease, the clinical expression of Borrelia infections in man is an important health problem. The geographic distribution of B. burgdorferi infections in equidae should resemble that of human cases because the vector tick involved, Ixodes ricinus, feeds on both species and, indeed, the infection has been established many times in horses. However, a definite diagnosis of the disease "Lyme borreliosis" in human beings as well as in horses and other animals is often difficult to accomplish. Although a broad spectrum of clinical signs has been attributed to B. burgdorferi infections in horses, indisputable cases of equine Lyme borreliosis are extremely rare so far, if they exist at all.

show abstract

Lack of correlation between exposure to lyme disease (Borrelia burgdorferi) and pregnancy loss in mares

Cited by 5 publications

References 8 publications

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

Infectious Diseases of the Puerperal Period

Borrelia burgdorferiinfections with special reference to horses. A review

Contact Info

Product

Resources

About