2018
DOI: 10.1002/ajh.25009
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Lack of correlation between heart, liver and pancreas MRIR2*: Results from long‐term follow‐up in a cohort of adult β‐thalassemia major patients

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Cited by 12 publications
(7 citation statements)
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“…Ferritin, LIC and cardiac T2* are considered as markers of iron overload, but the correlation between those markers and risk of endocrine complications is controversial, 20 since many studies have shown no correlation, [21][22][23] confirming our results. This disconnection with iron overload parameters has been observed also in chronic metabolic syndromes, although substantial evidence shows that the clinical course of these disorders is affected by iron overload.…”
Section: Discussionsupporting
confidence: 82%
“…Ferritin, LIC and cardiac T2* are considered as markers of iron overload, but the correlation between those markers and risk of endocrine complications is controversial, 20 since many studies have shown no correlation, [21][22][23] confirming our results. This disconnection with iron overload parameters has been observed also in chronic metabolic syndromes, although substantial evidence shows that the clinical course of these disorders is affected by iron overload.…”
Section: Discussionsupporting
confidence: 82%
“…Removing iron from the pancreas seems to be more difficult compared to other organs. Pancreatic iron (evidence of a period of inadequate ICT) remains even after the liver and heart are unloaded [62] (Figure 2), as we observed in both Case 1 and In cases like these, with liver and heart unloaded, any attempt to remove the pancreatic overload by increasing ICT puts the patient at risk of over-chelation. Consequently, it is more important to consider the 24 h coverage effect of the chelators than the dose [35].…”
Section: Dfo Dfp Dfxmentioning
confidence: 58%
“…However, the MTT assay revealed a significantly decreased number of viable cells in the NF fibroblasts (NF1 ∼27%, NF2 ∼22%), which was more consistent in the iPSC-derived NPCs (NF1 ∼46%, NF2 ∼52%) and neurons (NF1 ∼52%, NF2 ∼51%) compared with the controls. To confirm the specific involvement of free iron in eliciting cell death, neurons were grown for 3 weeks in the presence of the iron chelator deferiprone (5 μM) (Pinto et al., 2018). The addition of deferiprone prevented the death of the NF-derived neurons (∼90% NF1 and ∼94% NF2 viable cells), demonstrating that iron is the leading cause of neuronal death.…”
Section: Resultsmentioning
confidence: 99%