Lack of correlation between HLA match and long-term survival in living donor kidney transplantation

Klein, Tirza; Shapira, Z; Nathan, Naveen; Shaharabani, E; Or, H.; Zakai, Chana; Shabtai, E; Yussim, A.

doi:10.1016/s0041-1345(00)00943-x

Cited by 1 publication

(2 citation statements)

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“…In the UNOS registry report, they found that recipients over the age 60 years and under the age of 19 had poorer graft survival, and when the recipients was over age 60 years, more than 60% of graft failure were accounted for by death with graft function [33]. In living-related renal transplants these findings could be confirmed [18], while the same trend was not argued by some other authors [29]. The determinant effect of recipient age could be elucidated by our study on long-term survivors by multivariate analysis.…”

Section: Discussionmentioning

confidence: 96%

“…Our data show a significant impact of DR matching and long-term graft survival but a poor correlation between HLA-A and -B matching and graft survival. Many authors did not find a correlation between HLA-A, -B matching and long-term survival in living donor kidney transplantation [18, 29, 30], while some studies confirm this correlation [31, 32]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of Long-Term Live-Donor Renal Allograft Survivors

El‐Agroudy

Bakr²,

Hassan³

et al. 2003

Am J Nephrol

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Background/Aims: Despite the high rate of rejection, allograft failure and patient mortality in the early years of renal allotransplantation, some patients have done-remarkably well. We report here on 62 renal transplant recipients out of 144 patients (43%) who had functioning grafts for more than 15 years (range 15–24 years). Materials: Demographic and follow-up data for patients fulfilling the criteria were reviewed. These patients include 43 males and 19 females, with a mean age at transplantation of 27.5 ± 6.6 years (range 9–43 years), and mean donor age of 30 ± 8.6 years. The donor source was 8 parents, 49 siblings and 5 unrelated. The main causes of end-stage renal disease were chronic pyelonephritis and chronic glomerulonephritis. Twenty-nine patients were treated with cyclosporine (CsA) while 33 patients were primarily immunosuppressed by steroids and azathioprine. Results: Acute rejection episodes occurred in 40 patients (64.3%), out of them 19 patients experienced two or more acute rejection episodes. Univariate analysis showed that recipient and donor age, HLA-DR matching, pre- and post-transplant hypertension, ATN, delayed diuresis and chronic allograft nephropathy are significant risk factors; while recipient age, delayed diuresis and post-transplant hypertension were still significant by multivariate analysis. Conclusions: We concluded that renal transplantation, even in its earliest years and despite the numerous complications, has provided 15 or more years of near-normal life to patients with end-stage renal disease. Certain characteristics of long-term renal allograft survivors include young donor/recipient pairs, good DR matching with less pre- and post-transplantation prevalence of hypertension.

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Section: Discussionmentioning

confidence: 96%