Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study

Sebbag, Lionel; Allbaugh, Rachel A.; Strong, Travis D.; Strauss, Rachel; Wehrman, Rita F.; Foote, Braidee C.; Peterson, Chimene S.; Ben‐Shlomo, Gil

doi:10.1016/j.tvjl.2018.01.003

Cited by 6 publications

(10 citation statements)

References 12 publications

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“…Finally, the Clerapliq ® treatment used in these case reports did not result in any local or systemic side effects in treated dogs. This is in accordance with the safety data obtained from more than thousands of dogs and cats treated by Clerapliq ® in Europe (TVM) and with the publications on Clerapliq ® [36]. Also, as mentioned in the introduction, the equivalent of Cleraplic ® in humans is called Cacicol ® , which is a medical device that has been successfully used for more than 50,000 patients with no reported local or systemic side effects [37][38][39].…”

Section: Discussionsupporting

confidence: 86%

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Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs

Martinez¹,

Chiappini²,

Barritault

2019

Veterinary Sciences

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Superficial corneal ulcers that fail to heal within a normal time period and are refractory to conventional therapy in dogs are common in veterinary practice. Different etiologies can lead to this result, including spontaneous chronic corneal epithelial defects (SCCEDs) and ulcerative keratitis associated with bullous keratopathy. Thus, there is an urgent need to find new therapeutic approaches such as matrix therapy replacement. To determine the efficacy of a new ophthalmic treatment (Clerapliq ® ) for SCCEDs and ulcerative keratitis associated with bullous keratopathy, a total of 11 dogs referred to the clinic because of nonhealing erosive ulcers after a classic primary treatment were enrolled to get this new treatment. Dogs underwent ophthalmic exams and 7 dogs (10 eyes) were diagnosed with superficial ulceration and 4 dogs (5 eyes) with bullous keratopathy due to endothelial dystrophy/degeneration. They received eye drops of Clerapliq ® every 3 days until recovery. The results showed that the corneas with recurrences of the ulcers were resolved predominantly by using Clerapliq ® every 3 days in 83.3% of the cases during a period of treatment ranging between 6 to 35 days. Therefore, this new approach using matrix therapy regenerating technology in treating superficial ulcers and bullous keratopathy in dogs can be successfully considered as an adjunctive therapy.

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Section: Discussionsupporting

confidence: 86%

“…In a recent publication, OTR4120 was found to be no more effective than hyaluronic acid, considered as a placebo, for healing SCCED [36]. We believe that hand removal of the hyaline acellular zone in the anterior corneal stroma may be difficult to fully achieve, and for this reason, diamond burr is preferred.…”

Section: Discussionmentioning

confidence: 97%

Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs

Martinez¹,

Chiappini²,

Barritault

2019

Veterinary Sciences

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“…In rabbits it facilitated cornea healing after alkali injuring [11]. Other studies showed no change in healing time in humans [2], rabbits [30], and dogs [28], which is in accordance with our results. Corneal epithelialisation was neither promoted nor impaired.…”

Section: Rgtasupporting

confidence: 93%

“…The improvement in healing times with the use of topically applied regenerating agents (RGTAs) has been evaluated in several species such as humans, dogs, and rabbits and showed conflicting results [ [30]. By replacing and mimicking degraded heparin-sulfate, which is bound to extracellular matrix proteins thus protecting them from proteolysis, RGTAs stimulate the regeneration process [18] [28]. By the time the analysis of this study was finished, their effectiveness had not been evaluated in equine patients before.…”

Section: Introductionmentioning

confidence: 99%

Equine non-healing corneal ulcers: a retrospective evaluation of 57 cases (2001–2017)

Prucha

Tichy

Nell

2020

Tierarztl Prax Ausg G Grosstiere Nutztiere

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Background and objectives Non-healing corneal ulcers (NHCU) are a common problem in equine practice and several treatment options are available with different success and healing times. The aim of this retrospective study was to evaluate and to compare treatment protocols, clinical courses, corneal healing time and outcomes of NHCU. Methods From December 2001 to December 2017, a total of 57 horses with NHCU were presented at the Vetmeduni Vienna. Recorded data included affected eye, signalment, clinical symptoms, season of diagnosis, treatment protocols, complications and corneal healing rate. Results Sixty-three eyes were diagnosed with a NHCU. Follow-up information was available for 48/63 eyes. For those treated medically mean corneal healing time was 15.7 days (± SD 12.0). Medical treatment included topical antibiotics, antimycotics, cycloplegics, and systemic anti-inflammatory drugs. Twelve eyes received treatment with a poly-carboxymethylglucose-sulfate regenerating agent (Cacicol®; Thea Pharma GmbH, Wien, Austria). Other common additional treatments included debridement with an iodine drenched cotton tip (48 eyes; 76.2 %) and diamond burr debridement (30 eyes; 47.6 %). A bandage contact lens (BCL) was used for 10 eyes. Each eye received at least one additional treatment, although none of them led to a statistically significant alteration in healing time. Only usage of a BCL significantly increased healing time when compared to not using a BCL (p = 0.035). When all treatments failed, superficial keratectomy with placement of a conjunctival flap was performed. Secondary complications included stromal cellular infiltration, keratomycosis, keratomalacia, and corneal abscess formation. Conclusions Results correlated with those previously described and thus demonstrated the difficulty and complexity of this disease. Further research is needed to determine an optimal treatment protocol for non-healing ulcers in horses. Clinical relevance Since NHCUs are a commonly encountered problem in equine practice a reliable treatment protocol is required. This study reflects the problems with those ulcers and provides several protocols for possible treatments.

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“…As with all diseases, for ulcerative keratitis, it is necessary to have an assessment system that best reflects the clinical and epidemiological characteristics of dogs affected by different environmental factors. Although various studies exist on corneal ulcers 13,14 , no studies have used deep learning and/or other technical algorithms to assist in diagnosing such ulcers. Therefore, this study uses a CNN to determine the severity of corneal ulcers.…”

Section: Introductionmentioning

confidence: 99%

CNN-based diagnosis models for canine ulcerative keratitis

Kim

Lee

Choi

et al. 2019

Sci Rep

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the purpose of this methodological study was to develop a convolutional neural network (cnn), which is a recently developed deep-learning-based image recognition method, to determine corneal ulcer severity in dogs. the cnn model was trained with images for which corneal ulcer severity (normal, superficial, and deep) were previously classified by veterinary ophthalmologists' diagnostic evaluations of corneal photographs from patients who visited the Veterinary Medical teaching Hospital (VMtH) at Konkuk University and 3 different veterinary ophthalmology specialty hospitals in Korea. The original images (depicting normal corneas (36) and corneas with superficial (47) ulcers, deep (47) ulcers), flipped images (total 520), rotated images (total 520), and both flipped and rotated images (total 1,040) were labeled, learned and evaluated with GoogLenet, Resnet, and VGGnet models, and the severity of each corneal ulcer image was determined. to accomplish this task, models based on tensorflow, an opensource software library developed by Google, were used, and the labeled images were converted into TensorFlow record (TFRecord) format. The models were fine-tuned using a CNN model trained on the imagenet dataset and then used to predict severity. Most of the models achieved accuracies of over 90% when classifying superficial and deep corneal ulcers, and ResNet and VGGNet achieved accuracies over 90% for classifying normal corneas, corneas with superficial ulcers, and corneas with deep ulcers. This study proposes a method to effectively determine corneal ulcer severity in dogs by using a CNN and concludes that multiple image classification models can be used in the veterinary field. Deep learning diagnostic tools for image recognition have recently been tested in many medical fields. In the field of imaging diagnostics, the use of such tools have been reported in The Veterinary Journal 1,2. Recent advances in computer hardware technology, such as high performance graphic processing units (GPUs), have permitted the development of deep neural networks (DNNs). Deep learning algorithms are an evolution of neural networks and are currently used in a variety of medical and industrial applications 3,4. Deep learning fundamentally consists of a deep neural network structure with several layers. An artificial neural network based on the backpropagation 5 algorithm was highly anticipated in the 1990s; such a network would utilize logic that corrects the error of each neuron after analyzing the error in the reverse direction at the output side when the error occurs. However, research has stagnated because learning in artificial neural network models becomes more difficult as the number of layers increases. Since the mid-2000s, artificial neural networks have been improved with respect to learning methods: huge amounts of data have been made available, and the hardware environment has been improved, leading to remarkable performance improvements. In addition, the dataset overfitting problem, which was a persistent issue with artificial n...

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Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study

Cited by 6 publications

References 12 publications

Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs

Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs

Equine non-healing corneal ulcers: a retrospective evaluation of 57 cases (2001–2017)

CNN-based diagnosis models for canine ulcerative keratitis

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