Lack of Effect of Alcohol on Pituitary‐Gonadal Hormones in Women

McNamee, Brian; Grant, J. K.; Ratcliffe, John G.; Ratcliffe, W. A.; Oliver, J.S.

doi:10.1111/j.1360-0443.1979.tb01354.x

Cited by 37 publications

(12 citation statements)

References 2 publications

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“…In previous studies, ethanol increased cortisol levels in some studies (King et al 2002;McCaul et al 2001), but not in others (Dai et al 2002), and high doses may be required to observe this effect (King et al 2002). Several previous studies also found no effect of ethanol on progesterone (McNamee et al 1979;Mendelson et al 1989;Valimaki et al 1983) or estradiol (Sarkola et al 1999) levels during the follicular or luteal phases of the menstrual cycle. However, ethanol-induced elevation of estradiol and reduction of progesterone have been reported in women using oral contraceptives, while only a reduction in progesterone was found in women that did not use oral contraceptives (Sarkola et al 1999).…”

Section: Discussionmentioning

confidence: 83%

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Holdstock

Penland²,

Morrow³

et al. 2005

Psychopharmacology

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3alpha,5alpha-THP-like immunoreactivity levels in human plasma are not increased following moderate ethanol consumption, suggesting that circulating levels of progesterone or its tetrahydro-reduced metabolites do not play a major role in ethanol action. However, the possibility remains that ethanol increases endogenous brain production of GABAergic neurosteroids without affecting plasma levels. Moreover, humans synthesize 5beta-reduced GABAergic steroids, and levels of these steroids may be altered in plasma or brain.

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Section: Discussionmentioning

confidence: 83%

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Holdstock

Penland²,

Morrow³

et al. 2005

Psychopharmacology

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“…Earlier studies reported similar effects on PROG among premenopausal women who were not using oral contraceptives (Teoh et al 1990). Although contradictory results have been reported in other studies (McNamee et al 1979;Valimaki et al 1983;Mendelson et al 1989;Martin et al 1999;Garcia-Closas et al 2002;Torres and Ortega 2003;Holdstock et al 2005), most of these studies involved small study samples, resulting in low statistical power. Recently, Hill et al (2005) found depressed PROG and a decreased PROG/PREG ratio in the absence of alcohol administration among premenopausal women undergoing alcoholism treatment.…”

Section: Discussionmentioning

confidence: 86%

Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol

et al. 2005

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Background: GABA A receptors are an important site of action of endogenous neurosteroids and an important mediator of several behavioral effects of alcohol. This study examined the effects of alcohol on plasma steroid hormone concentrations on the hypothesis that the endocrine effects mediate some of the subjective effects of alcohol. Methods: Thirty-two healthy subjects (17 men) with no history of a substance use disorder participated in this human laboratory study. All subjects consumed three standard drinks of grain alcohol. Subjective measures and blood samples for steroid concentrations were collected at baseline and 40 min after alcohol consumption. Results: Alcohol increased self-reported stimulation, alcohol liking, and desire for more alcohol. Alcohol also increased pregnenolone (PREG) and dehydroepiandrosterone (DHEA) concentrations, while it decreased progesterone (PROG) and allopregnanolone (ALLO) concentrations, as well as ALLO/PREG and PROG/PREG ratios. In men, the change in PREG concentration was significantly correlated with alcohol liking, while the alcohol-induced change in ALLO concentration correlated significantly with both alcohol liking and desire for more alcohol. Discussion: These findings provide preliminary support for the hypothesis that endogenous neurosteroids mediate some of the subjective effects of alcohol. Efforts to replicate these findings should aim to specify more clearly the nature and time course of the effects.

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“…has been without effect on serum concentrations of LH, FSH, oestrogens and progesterone during both the follicular [6,7] and luteal [8] phase of the menstrual cycle. In studies with healthy female volunteers, acute administration of alcohol in doses of 0.8-1 *2 g kg-' of body weight (b.w.)…”

Section: Discussionmentioning

confidence: 99%

Pituitary‐gonadal hormones and adrenal androgens in non‐cirrhotic female alcoholics after cessation of alcohol intake

Välimäki

Pelkonen

Härkönen

et al. 1990

Eur J Clin Investigation

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To investigate the sex-hormone profiles associated with chronic alcoholism in women we examined 16 non-cirrhotic alcohol abusers (aged 18-46 years). They were admitted for the treatment of alcoholism (duration of 2-16 yrs) to a social hospital for 6 weeks. Their mean daily alcohol consumption was 170 g. Blood samples for serum LH, FSH, prolactin (PRL), oestrone (El), oestradiol (E2), progesterone (P), 17-a-hydroxyprogesterone (1 7-OHP), androstenedione (A) and dehydroepiandrosterone (DHEA) were drawn three times a week during the hospital stay. Similar blood samples were taken from 10 control women during one menstrual cycle. The cycles were anovulatory in two patients and in none of controls. Serum LH and FSH leveb were similar in alcoholic and control women but serum concentrations of PRL were increased 2-4-fold in alcoholic women. In the patients serum, concentrations of El and E2 tended to be lower during the follicular and midcycle phases, as did those of P and 17-OHP during the luteal phase. Compared with the controls, serum levels of A were increased 2-3-fold in the patients. A parallel difference between the two groups was seen in serum DHEA concentrations. W e conclude that until liver injury, even heavy alcohol drinking has only minor effects on the secretion of gonadotrophins and ovarian steroids. Hypersecretion of PRL and adrenal androgens may well be an initiating mechanism for sexual dysfunction of female alcoholics.

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Lack of Effect of Alcohol on Pituitary‐Gonadal Hormones in Women

Cited by 37 publications

References 2 publications

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol

Pituitary‐gonadal hormones and adrenal androgens in non‐cirrhotic female alcoholics after cessation of alcohol intake

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