Lack of effect of foods enriched with plant- or marine-derived n−3 fatty acids on human immune function

Kew, Samantha; Banerjee, T.; Minihane, Anne‐Marie; Finnegan, Yvonne E.; Müggli, Reto; Albers, Ruud; Williams, Christine M.; Calder, Philip C.

doi:10.1093/ajcn/77.5.1287

Cited by 156 publications

(136 citation statements)

References 29 publications

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“…In healthy volunteers, increasing fish oil intake suppressed the in vitro synthesis of interleukin-2, interleukin1b, interleukin-1a, and tumor necrosis factor-a (Endres et al, 1989(Endres et al, , 1993. However, placebo-controlled studies found that fish oil does not affect ex vivo cytokine production (Blok et al, 1997) or the functional activity of neutrophils, monocytes, or lymphocytes in healthy humans (Kew et al, 2003). Few studies investigated effects of n-3 fatty acids on CRP.…”

Section: Discussionmentioning

confidence: 99%

Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects

et al. 2004

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Objective: High-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, is a powerful predictor of cardiovascular risk. We hypothesised that n-3 fatty acids reduce underlying inflammatory processes and consequently CRP concentrations in healthy middle-aged subjects. Design: Placebo-controlled, double-blind study. Subjects: A total of 43 men and 41 postmenopausal women aged 50-70 y. Before and after intervention, we measured serum CRP concentrations with an enzyme immunoassay. Interventions: Capsules with either 3.5 g/day fish oil (1.5 g/day n-3 fatty acids) or placebo for 12 weeks. Results: The median CRP change in the fish oil group did not significantly differ from that in the placebo group (0.01 vs À0.17 mg/l, P ¼ 0.057). Conclusion:The currently available data -including ours-do not support that beneficial effects on CRP are involved in a mechanism explaining the protective effect on heart disease risk of n-3 fatty acids as present in fish.

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Section: Discussionmentioning

confidence: 99%

Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects

et al. 2004

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“…Plasma phospholipids may be a mechanism to transport PUFAs to cells and tissues, and their fatty acid composition reflects that of the membranes of some cells [154]. The effect of increased ALA intake on fatty acids in plasma phospholipids has been reported in several studies.…”

Section: Increased Intake Of Alpha-linolenic Acidmentioning

confidence: 99%

“…Increased consumption of ALA or SDA has been shown to increase the proportion of EPA and DPA in membranes of inflammatory cells such as neutrophils, monocytes and lymphocytes [38,99,107,128,130,133,[152][153][154]163] (Tables 7 and 8), indicating the potential of plant derived ω-3 PUFAs to reduce inflammation and to protect against chronic inflammatory diseases.…”

Section: Alpha-linolenic Acid Stearidonic Acid and Inflammationmentioning

confidence: 99%

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker

Miles

Burdge

et al. 2016

Progress in Lipid Research

354

292

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“…Consequently, it could not be excluded that the increased incorporation of DHA in neutrophil lipids and the subsequent production of LT observed for each dose of DHA may also reflect the effect of cumulative doses of DHA. Results from human studies indeed indicate that the level of DHA reached a plateau after 18 weeks of dietary supplementation (18) and most of the published data reported longer supplementation periods (from 3 weeks to 6 months (5,6,8,9,13) ). However, the present data suggest that changes in total lipid content occurred within 2 weeks and therefore earlier than that reported until now.…”

Section: Discussionmentioning

confidence: 96%

Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers

et al. 2008

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n-3 PUFA supplementation helps in the prevention or treatment of inflammatory diseases and CVD. However, many supplementations reported so far are either a combination of n-3 PUFA or used large daily amounts of n-3 PUFA dosages. The present study investigated the influence of increasing dose intake of DHA on the fatty acid composition of phospholipids in neutrophils and on their capability to produce leukotrienes (LT) B4 and B5in vitro. Twelve healthy volunteers were supplemented with increasing daily doses of DHA (200, 400, 800 and 1600 mg, each dose in TAG containing DHA as the only PUFA and for a 2-week period). At the end of each supplementation period, neutrophil fatty acid composition, and LTB4 and LTB5 production were determined by GC and liquid chromatography–tandem MS, respectively. The DHA/arachidonic acid ratio increased in a dose-dependent manner with respect to the increasing doses of DHA supplementation and was significantly different from baseline after supplementation with either 400, 800 or 1600 mg DHA. The LTB5/LTB4 ratio was significantly increased compared to baseline after supplementation with 800 and 1600 mg DHA. LTB5/LTB4 and DHA/arachidonic acid ratios were correlated (r 0·531, P < 0·0001). The present data suggest that both changes in neutrophil lipid composition and LT production occurred with daily supplementation with 800 and 1600 mg DHA. The clinical benefits associated with these doses of DHA in inflammatory diseases remain to be investigated.

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Lack of effect of foods enriched with plant- or marine-derived n−3 fatty acids on human immune function

Abstract: An intake of

Cited by 156 publications

References 29 publications

Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects

Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers

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