Lack of effect of propranolol and metoprolol on glucose tolerance in maturity-onset diabetics.

Woods, K L; Wright, Alexander D.; Kendall, M J; Black, Elena

doi:10.1136/bmj.281.6251.1321

Cited by 13 publications

(3 citation statements)

References 5 publications

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“…However, many other studies have used oral or intravenous glucose tolerance tests to assess this aspect of P-blockade. Two studies suggest that nonselective P-blockade but not cardioselective Pblockade cause a deterioration in fasting blood glucose and/or glucose tolerance in diabetics while a third study was unable to confirm this (Holm et al, 1980;Groop et al, 1982;Woods et al, 1980). A third major area of concern is the deleterious effect that P-blockers have on plasma lipids.…”

Section: Choice Of Antihypertensive Therapymentioning

confidence: 99%

The choice of antihypertensive therapy in the diabetic patient

Struthers

1985

Postgraduate Medical Journal

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Section: Choice Of Antihypertensive Therapymentioning

confidence: 99%

The choice of antihypertensive therapy in the diabetic patient

Struthers

1985

Postgraduate Medical Journal

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“…Woods , Wright, Kendall and Black (1980), were not able to show different metabolic effects of metoprolol and propranolol on glucose tolerance and insulin secretion. The number of patients was however low, and the period of assignment to each treatment was shorter than ours.…”

Section: Discussionmentioning

confidence: 85%

Effects of Metoprolol and Propranolol on Glucose Tolerance and Insulin Secretion in Diabetes Mellitus

Micossi

Pollavini²,

Raggi

et al. 1984

Horm Metab Res

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Twenty-two hypertensive diabetic patients were admitted to a double-blind, within-patient study, and treated with propranolol 80 mg and metoprolol 100 mg twice daily for 4 weeks according to a cross-over design. Dosages of the two drugs such as to induce comparable cardiovascular effects, did not induce relevant changes of fasting blood glucose levels in patients receiving the oral hypoglycaemic agent glibenclamide (group 1), insulin (group 2) or diet alone (group 3). Glucose tolerance, assessed with a 75 g oral load, was however decreased by propranolol, and not by metoprolol in the glibenclamide-treated group. Glucose-induced insulin secretion was reduced by propranolol and not by metoprolol both in the group treated by diet alone and in the glibenclamide-treated group. It is concluded that cardioselective metoprolol seems to be more suitable than the non-selective propranolol in the treatment of arterial hypertension in diabetic subjects, particularly when sulfonylureas are being used as hypoglycaemic agents.

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“…Woods et al (32) , however , denied this adverse effects of beta-blocker. In our series, HbAl levels in those treated with beta-blocker for the mean 18month period were not significantly different from those in other groups.…”

Section: Discussionmentioning

confidence: 96%

Diuretics and Other Antihypertensive Drugs and Glycemic Control in Non-Insulin-Dependent Diabetics with Hypertension A Survey By the Fukuoka Diabetes Clinic Group

Tsutsu

Nunoi

Yokomizo

et al. 1989

Clinical and Experimental Hypertension. Part A: Theory and Prac

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We compared the levels of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1) in non-insulin-dependent diabetics with hypertension who were treated with monotherapy of diuretics or other antihypertensive drugs (AHD) and in those who were not given any AHD. Total 162 patients were divided into the four groups; the control group without AHD (n = 45), the diuretics group (n = 42), the beta-blocker group (n = 30) and the Ca-antagonist group (n = 45). FPG and HbA1 levels were 153 +/- 44 mg/dl and 10.0 +/- 2.3% for the control group, 145 +/- 55 mg/dl and 9.8 +/- 2.2% for the diuretics, 165 +/- 63 mg/dl and 10.2 +/- 2.1% for the beta-blocker and 158 +/- 42 mg/dl and 10.4 +/- 2.0% for the Ca-antagonist, respectively. There were no significant differences in the levels of FPG and HbA1 among the four groups. Multivariate analysis also revealed no difference in glycemic control even when anti-diabetic treatment (diet alone, oral hypoglycemic agents or insulin), body mass index, serum potassium, systolic and diastolic blood pressures and age were taken into account. Blood pressure levels did not differ among the groups except control and they were well controlled at the low doses of AHD. Our results suggest that the choice of low dose diuretics for the treatment of hypertension in non-insulin-dependent diabetics might not be necessarily excluded by the only reason of the possible deleterious influence on glycemic control.

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Lack of effect of propranolol and metoprolol on glucose tolerance in maturity-onset diabetics.

Cited by 13 publications

References 5 publications

The choice of antihypertensive therapy in the diabetic patient

The choice of antihypertensive therapy in the diabetic patient

Effects of Metoprolol and Propranolol on Glucose Tolerance and Insulin Secretion in Diabetes Mellitus

Diuretics and Other Antihypertensive Drugs and Glycemic Control in Non-Insulin-Dependent Diabetics with Hypertension A Survey By the Fukuoka Diabetes Clinic Group

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