Lack of effectiveness of dexamethasone in neonatal bacterial meningitis

Daoud, Azhar S.; Batieha, Anwar; Al-Sheyyab, Mahmoud; Abu-Ekteish, Faisal; Obeidat, Ahmad M.; Mahafza, Tareq

doi:10.1007/s004310051056

Cited by 79 publications

(44 citation statements)

References 13 publications

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“…The possibility of preventing the progressive formation of ventricular septa and loculations with corticosteroids in PIH was discussed by Schultz and Leeds. 24 Whether immune modulation 8,9,16 during NS might reduce this degree of damage to the brain in such patients remains an open question.…”

Section: Discussionmentioning

confidence: 99%

Association of bacteria with hydrocephalus in Ugandan infants

Padhi

Ranjeva

et al. 2011

PED

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Object Infantile hydrocephalus in East Africa is predominantly postinfectious. The microbial origins remain elusive, since most patients present with postinfectious hydrocephalus after antecedent neonatal sepsis (NS) has resolved. Methods To characterize this syndrome in Ugandan infants, the authors used polymerase chain reaction targeting bacterial 16S ribosomal DNA from CSF to determine if bacterial residua from recent infections were detectable. Bacteria were identified based on the relationship of genetic sequences obtained with reference bacteria in public databases. The authors evaluated samples from patients presenting during dry and rainy seasons and performed environmental sampling in the villages of patients. Results Bacterial DNA was recovered from 94% of patients. Gram-negative bacteria in the phylum Proteobacteria were the most commonly detected. Within this phylum, Gammaproteobacteria dominated in patients presenting after infections during the rainy season, and Betaproteobacteria was most common following infections during the dry season. Acinetobacter species were identified in the majority of patients admitted after rainy season infection. Conclusions Postinfectious hydrocephalus in Ugandan infants appears associated with predominantly enteric gram-negative bacteria. These findings highlight the need for linking these cases with antecedent NS to develop more effective treatment and prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Association of bacteria with hydrocephalus in Ugandan infants

Padhi

Ranjeva

et al. 2011

PED

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“…A recent meta-analysis concluded that the drug is effective in preventing hearing loss in H. influenzae meningitis and has some beneficial effects on hearing and neurologic sequelae in pneumococcal meningitis when given before or at the time of the first antibiotic dose (11). However, in most of the individual trials, these benefits were either marginal or could not be detected at all (12). Furthermore, H. influenzae meningitis has virtually disappeared in countries that have implemented programs with conjugated vaccines in infants and children (13).…”

Section: Institute For Infectious Diseases University Of Bern Ch-30mentioning

confidence: 99%

Dexamethasone Aggravates Hippocampal Apoptosis and Learning Deficiency in Pneumococcal Meningitis in Infant Rats

et al. 2003

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“…Cochrane review data supports its use in patients with bacterial meningitis in high-income countries, but results were not found to be beneficial from low-income countries. (Daoud AS et al, 1999). Bacterial immunogenicity, host immunity and response, timing and efficacy of antibiotics and steroids used and susceptibility of organism all account for the consequences in low income countries.…”

Section: Role Of Anti Inflammatory Agentsmentioning

confidence: 99%

“…Steroids are also not advised as adjuvant therapy in patients with congenital or acquired CNS anomalies. (Daoud AS et al, 1999).…”

Section: Role Of Steroids In Meningitismentioning

confidence: 99%