Lack of effects on female fertility or pre- and postnatal development of offspring in rats after exposure to AS03-adjuvanted recombinant plant-derived virus-like particle vaccine candidate for COVID-19

Dubé, Charlotte; Paris-Robidas, Sarah; Primakova, Iryna; Destexhe, Éric; Ward, Brian J.; Landry, Nathalie; Trépanier, Sonia

doi:10.1016/j.reprotox.2021.11.006

Cited by 4 publications

(1 citation statement)

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“…Ergebnisse Im Tiermodell zeigten sich trotz sehr hoher Impfdosen keine negativen Effekte auf die Fertilität, den Schwangerschaftsverlauf und die fetale Entwicklung 1 2 3 . Auf humaner Seite wurde bei infizierten Frauen keine SARS-CoV-2 RNA in Oozyten/Follikelflüssigkeit nachgewiesen 4 5 6 ; ebenso zeigten sich zwischen Genesenen, Geimpften und Kontrollen keine Unterschiede hinsichtlich Schwangerschafts- oder Lebendgeburtenrate sowie der Gesundheit der Kinder (7–11).…”

unclassified

SARS-CoV-2-Infektion, Corona-Impfung und Reproduktion

Feil

Braun

Reiser

et al. 2022

Geburtshilfe Und Frauenheilkunde

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unclassified

SARS-CoV-2-Infektion, Corona-Impfung und Reproduktion

Feil

Braun

Reiser

et al. 2022

Geburtshilfe Und Frauenheilkunde

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A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals

Domingo

2024

Arch Toxicol

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Since the reports of the first cases of COVID-19, in less than 5 years, a huge number of documents regarding that disease and the coronavirus (SARS-CoV-2), responsible for the infection, have been published. The tremendous number of scientific documents covers many topics on different issues directly related to COVID-19/SARS-CoV-2. The number of articles—including reviews—reporting adverse/side effects of the approved COVID-19 vaccines is considerable. A wide range of adverse/side effects have been reported in humans after COVID-19 vaccination: thrombotic events/thrombocytopenia, myocarditis/pericarditis, cutaneous reactions, immune-mediated effects, psychiatric adverse events, systemic lupus erythematosus, reproductive toxicity, and other miscellaneous adverse effects. In contrast, information on nonclinical studies conducted to assess the potential toxicity/adverse effects of the COVID-19 vaccines in laboratory animals, is comparatively very scarce. The present review was aimed at revising the scientific literature regarding the studies in laboratory animals on the toxic/adverse effects of COVID-19 vaccines. In addition, the investigations reported in those specific toxicology journals with the highest impact factors have been examined one by one. The results of the present review indicate that most nonclinical/experimental studies on the adverse/toxic effects of the COVID-19 vaccines and/or potential candidates showed—in general terms—a good safety profile. Only in some animal studies were certain adverse effects found. However, a rather surprising result has been the limited number of available (in the databases PubMed and Scopus) nonclinical studies performed by the companies that have been the largest manufacturers of mRNA vaccines in the world. It is assumed that these studies have been conducted. However, they have not been published in scientific journals, which does not allow the judgment of the international scientific community, including toxicologists.

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Adjuvants to increase immunogenicity of SARS-CoV-2 RBD and support maternal–fetal transference of antibodies in mice

Lima

Portilho

Gaspari

2022

Pathogens and Disease

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Adjuvants are important components of vaccines, increasing immunogenicity and modulating the immune response. SARS-CoV-2 vaccines are still being developed in order to improve worldwide access to immunization. Specific populations should be addressed in these investigations, such as pregnant women – to protect both mothers and neonates. In this study, female adult mice were immunized with Receptor-binding domain (RBD) from SARS-CoV-2 adjuvanted by a mixture of DDA and Saponin and put to mating to verify the maternal transference of IgG. For comparison, other group received RBD adjuvanted by OMVs from Neisseria meningitidis and Alum. The adjuvants enhanced IgG production and neutralization. DDA/Sap contributed to increase IgG1, IgG2a, IgG2b and IgG3 isotypes. Total IgG avidity was considered high, as well as IgG1, IgG2a and IgG2b avidity. IgG antibodies were effectively transferred to the offspring, predominantly IgG2a, IgG2b and IgG3. The passive transferred immunoglobulin maintained the neutralizing ability, although it lost avidity. ELISA data was confirmed in Dot-ELISA and Immunoblotting assays. DDA and Saponin seem a promising adjuvant mixture to enhance the humoral response of SARS-CoV-2 antigens. Further studies considering the effects of maternal immunization in the protection of offspring are needed, regardless the platform used in COVID-19 vaccines.

show abstract

Lack of effects on female fertility or pre- and postnatal development of offspring in rats after exposure to AS03-adjuvanted recombinant plant-derived virus-like particle vaccine candidate for COVID-19

Cited by 4 publications

References 46 publications

SARS-CoV-2-Infektion, Corona-Impfung und Reproduktion

SARS-CoV-2-Infektion, Corona-Impfung und Reproduktion

A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals

Adjuvants to increase immunogenicity of SARS-CoV-2 RBD and support maternal–fetal transference of antibodies in mice

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