Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn??s disease

Lomer, Miranda; Grainger, S. L.; Ede, R J; Catterall, A.; Greenfield, S.; Cowan, Robert Ernest; Vicary, F. R.; Jenkins, Anthony P; Fidler, Helen; Harvey, R.; Ellis, Richard; McNair, Alistair; Ainley, Colin; Thompson, R. P. H.; Powell, Jonathan J.

doi:10.1097/00042737-200503000-00019

Cited by 86 publications

(58 citation statements)

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“…In a double blind randomised study, Lomer et al (2002) demonstrated that a particle-low diet alleviated the symptoms of Crohn's disease. However, recent clinical findings have suggested that reducing microparticle intake in Crohn's sufferers has no effect on the disease (Lomer 2005). It is, therefore, evident that, despite initial attempts to establish the presence or absence of a link between compromised functionality of the GI tract and initiation or exacerbation of disease, there is a requirement for further research.…”

Section: The Influence Of Particles In Diseasementioning

confidence: 99%

Applications and implications of nanotechnologies for the food sector

Chaudhry¹,

Scotter²,

Blackburn³

et al. 2008

Food Additives & Contaminants: Part A

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525

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A review of current and projected nanotechnology-derived food ingredients, food additives and food contact materials is presented in relation to potential implications for consumer safety and regulatory controls. Nanotechnology applications are expected to bring a range of benefits to the food sector, including new tastes, textures and sensations, less use of fat, enhanced absorption of nutrients, improved packaging, traceability and security of food products. The review has shown that nanotechnology-derived food and health food products are set to grow worldwide and, moreover, a variety of food ingredients, additives, carriers for nutrients/supplements and food contact materials is already available in some countries. The current level of applications in the European food sector is at an elementary stage; however, it is widely expected that more and more products will be available in the EU over the coming years. The toxicological nature of hazard, likelihood of exposure and risk to consumers from nanotechnology-derived food/food packaging are largely unknown and this review highlights major gaps in knowledge that require further research. A number of uncertainties and gaps in relevant regulatory frameworks have also been identified and ways of addressing them proposed.

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Section: The Influence Of Particles In Diseasementioning

confidence: 99%

Applications and implications of nanotechnologies for the food sector

Chaudhry¹,

Scotter²,

Blackburn³

et al. 2008

Food Additives & Contaminants: Part A

1,094

525

View full text Add to dashboard Cite

show abstract

“…Eliminating foods containing microparticles does not benefit patients with Crohn's disease [63,64] . Omega-3 polyunsatured fatty acids have potential effect in decreasing inflammation in IBD and preliminary studies gave encouraging results.…”

Section: Diet As Therapymentioning

confidence: 99%

Smoking, Physical Activity, Nutrition and Lifestyle: Environmental Factors and Their Impact on IBD

Cosnes

2010

Dig Dis

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Current smoking increases the risk of developing Crohn’s disease and worsens its course, increasing the need for steroids, immunosuppressants, and re-operations. On the contrary, smoking protects against ulcerative colitis and after disease onset improves its course, decreasing the need for colectomy. Smoking cessation improves Crohn’s disease and worsens ulcerative colitis. Achieving smoking cessation in Crohn’s disease is thus an important goal of therapy, whereas patients with ulcerative colitis should not be discouraged to quit, because the beneficial effect of smoking for their disease is counterbalanced by the deleterious respiratory and cardiovascular effects of tobacco. Physical activity improves quality of life without detrimental effect on disease activity, and may contribute to increase muscle mass and to prevent osteoporosis. Regarding nutrition, a Western diet may be associated with an increased risk of IBD, and a case-control study revealed an increased consumption of linoleic acid before diagnosis of ulcerative colitis. Liquid diets may improve Crohn’s disease flares and decrease the need for steroids; however, there are no defined diets able to improve the disease course, and in Crohn’s disease, supplementation with omega-3 fatty acids did not show a significant benefit. Obesity is becoming more prevalent in IBD and may be associated with higher disease activity. In total, adhering to four simple lifestyle factors – never smoking, physical activity, prudent diet and body mass index <25 – may have a strong impact both on the prevention of major chronic diseases and on the course of IBD.

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“…There are at least seven sham-controlled dietary advice RCTs investigating the effect of 290 whole diet interventions reported in the literature (Table 2) (38)(39)(40)(41)(42)(43)(44)(45) . Most evaluate the effect of (40) , the patient's usual diet (41) , is relatively arbitrary (38,39,42,43) or excludes another 295 dietary component (44) .…”

mentioning

confidence: 99%

The challenges of control groups, placebos and blinding in clinical trials of dietary interventions

et al. 2017

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Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn??s disease

Abstract: Our adequately powered and carefully controlled dietary trial found no evidence that reducing microparticle intake aids remission in active Crohn's disease.

Cited by 86 publications

References 0 publications

Applications and implications of nanotechnologies for the food sector

Applications and implications of nanotechnologies for the food sector

Smoking, Physical Activity, Nutrition and Lifestyle: Environmental Factors and Their Impact on IBD

The challenges of control groups, placebos and blinding in clinical trials of dietary interventions

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