Lack of efficacy of alpha‐lipoic acid in burning mouth syndrome: A double‐blind, randomized, placebo‐controlled study

Carbone, Mario; Pentenero, Monica; Carrozzo, M; Ippolito, Alessio; Gandolfo, S

doi:10.1016/j.ejpain.2008.06.004

Cited by 77 publications

(180 citation statements)

References 21 publications

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“…The follow-up interview by phone call showed improvement of intraoral burning sensations in both groups (Omeprazole 40 mg twice a day in LPR patients, 600 mg of alpha-lipoic acid once a day in patients without LPR). Carbone et al [39] could show lack of efficacy of alphalipoic acid in burning BMS patients in a double blind, randomized, placebo-controlled study. Response rates of about 30% were found in the treatment groups as well as in the placebo group.…”

Section: Discussionmentioning

confidence: 98%

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Becker

Schmidt

Berghaus

et al. 2011

Eur Arch Otorhinolaryngol

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Intraoral burning sensations are a common problem in the otolaryngological practice. The aim of this study was to evaluate if laryngopharyngeal reflux can cause intraoral burning sensations by measuring oropharyngeal acid reflux. Patients with recurring intraoral burning sensations underwent oropharyngeal pH monitoring in our outpatient clinic. The pH catheter was placed at the level of the uvula. The catheter contained an externally worn transmitter, which wirelessly sent the data to a monitor. In addition, patients were instructed to indicate meals or the occurrence of burning sensations by pressing provided buttons on the monitor. Corresponding events of burning sensations and a significant decrease in oropharyngeal pH values should be visualized. Twenty two patients suffering from recurring intraoral burning sensations underwent oropharyngeal pH measurement for 21-25 h. We could find oropharyngeal reflux episodes in 11 patients. However, we could not detect any episodes of burning sensations in the mouth corresponding with a decrease in oropharyngeal pH values. Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients. Although further studies with more patients are necessary in the future, we conclude from our findings that recurring intraoral burning sensations are not an indication for proton pump inhibitor therapy.

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Section: Discussionmentioning

confidence: 98%

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Becker

Schmidt

Berghaus

et al. 2011

Eur Arch Otorhinolaryngol

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“…The communication of different therapeutic measures to control the BMS is wide in the world literature (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The Gabapentin was used by White et al (15) in a case of a patient with BMS obtaining healing of the case and it was subsequently used by Heckmann et al (16) who conducted a study with gabapentin in 15 patients, where the initial dose was 300 mg / day and then grew at a rate of 300 mg every 48 hours to a maximum of 2400 mg / day.…”

Section: Discussionmentioning

confidence: 99%

“…It also exerts a neuro-regenerative action, because it crosses the hematoencephalic barrier and has a protective effect of brain and nerve tissue (10,11). A systematic review of the Cochrane Collaboration, noted that Alpha-Lipoic Acid (ALA) may help in management of burning mouth syndrome (12). Various studies have shown that the use of ALA did not produce greater benefits on the burning mouth that the use of placebos (13,14).…”

Section: Introductionmentioning

confidence: 99%

Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: A randomized, double-blind, placebo controlled trial

López-D'alessandro¹,

Escovich²

2011

Med Oral

100

180

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Burning Mouth Syndrome (BMS) is a disease that manifests as burning in the tongue or in any area of the oral mucosa, in the absence of clinically verifiable injuries. Objectives: To verify the efficacy of alpha lipoic acid (ALA) and gabapentin (GABA), used individually and jointly, to reduce the burning in patients with burning mouth and establish a drug therapy for the BMS. Study Design: During April and May 2008, we conducted a randomized, double-blind, placebo-controlled trial in the Department of Clinical Stomatology, Faculty of Dentistry, Rosario, Argentina. The gathering of patients was between those ones with BMS who were treated in our service between March 2003 and March 2008 without complying with the applied treatments. The 120 patients were randomly divided into 4 groups and were provided, by lot and in a blinded fashion, with four different treatment cycles consisting of the following drugs: Group A (n = 20) 600 mg / day of alpha lipoic acid for two months, Group B (n = 20) 300 mg / day of gabapentin for two months, Group C (n = 20) a combination of both drugs for two months and Group D (n = 60) 100 mg / day of cellulose starch for two months (control group). Results and Conclusions: All 120 patients completed the treatment. The best response was obtained with the combination of ALA + GABA, with a 70% of the cases with reduced burning in this group and a 13.2 times greater chance of presenting positive changes for these patients than those taking placebo. The combined use of drugs that act at different levels of the nociceptive system can be useful for the treatment of this syndrome.

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“…According to the researchers, it is necessary to combine psychotherapy with the drugs, the reason for this being that psychogenic alterations are known to have a strong relation to BMS [2]. Carbone et al [67], López-Jornet et al [68] and Cavalcanti and Silveira [29] were not able to demonstrate any significant improvement in BMS patients when utilizing alpha-lipoic acid. Both the placebo effect and the different parameters that were used to calculate the intensity of the symptoms could be the source of possible explanations that account for such conflicting results.…”

Section: Treatmentmentioning

confidence: 99%

Burning Mouth Syndrome. Update

Jc¹,

E²,

Ej³

et al. 2014

J. Dentists

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Burning Mouth Syndrome (BMS) is a chronic disorder that predominately affects middle-aged women in the postmenopausal period. The condition is distinguished by burning symptoms of the oral mucosa and the absence of any clinical signs. The etiology of BMS is complex and it includes a variety of factors. Local, systemic and psychological factors such as stress, anxiety and depression are listed among the possible causes of BMS. BMS may sometimes be classified as BMS Type I, II or III. Although this syndrome is not accompanied by evident organic alterations and it does not present health risks, it can significantly reduce the patient's quality of life. This study analyzes the available literature related to BMS, and makes special reference to its therapeutic management. The pages that follow will also discuss the diagnostic criteria that should be respected, etiological factors, and clinical aspects. We used the PubMed database and searched it by using the keywords "burning mouth syndrome", "BMS and review", and "burning mouth and review", in the title or abstract of the publication. BMS treatment usually steers towards the management of the symptoms; however, the specific local factors that could play a significant role in worsening the oral burning sensation should be eradicated. The most widely accepted treatment options that show variable results include tricyclic antidepressants, benzodiazepines and antipsychotic drugs; nevertheless there are other therapies that can also be carried out. Professionals that work in the field of dentistry should formulate standardized symptomatic and diagnostic criteria in order to more easily identify the most effective and reliable strategies in BMS treatment through multidisciplinary research.

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Lack of efficacy of alpha‐lipoic acid in burning mouth syndrome: A double‐blind, randomized, placebo‐controlled study

Cited by 77 publications

References 21 publications

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: A randomized, double-blind, placebo controlled trial

Burning Mouth Syndrome. Update

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