Lack of immune response to methyl methacrylate in lymphocyte cultures

Santavirta, Seppo; Konttinen, Yrjö T.; Bergroth, Ville; Grönblad, Mats

doi:10.3109/17453679108993087

Cited by 45 publications

(11 citation statements)

References 12 publications

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“…Thus, the prosthetic interface provides a complex series of interactions of cells, cytokines and other substances which modulate bone remodelling. With cemented implants, differences were also found in the T-lymphocyte subgroups, suggesting a possible role for immunological processes in osteolysis, but this is con- troversial and there are studies which advocate 21,32,[43][44][45][46][47][48] and refute [49][50][51][52][53][54] a role for T-cell modulation of the macrophage response to biomaterials. 55,56 With cementless prostheses there were fewer differences in cell number and cytokine profile in the various groups.…”

Section: Discussionmentioning

confidence: 98%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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T he tissues surrounding 65 cemented and 36 cementless total joint replacements undergoing revision were characterised for cell types by immunohistochemistry and for cytokine expression by in situ hybridisation.We identified three distinct groups of revised implants: loose implants with ballooning radiological osteolysis, loose implants without osteolysis, and well-fixed implants. In the cemented series, osteolysis was associated with increased numbers of macrophages (

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Section: Discussionmentioning

confidence: 98%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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“…Diamondlike carbon is an ideal surface coating for prosthetic joints, because it is wear resistant, atomically smooth, and corrosion resistant, has a low friction coefficient, and is immune to scratching by third body wear particles [39][40][41][42][43]. For example, Tiainen et al demonstrated that the amount of wear in DLC-coated metal/DLC-coated metal wear couples was 10 5 -10 6 times lower than in conventional metal/polyethylene and metal/metal wear couples [44].…”

Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

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Implants containing antimicrobial metals may reduce morbidity, mortality, and healthcare costs associated with medical device-related infections. We have deposited diamondlike carbonsilver (DLC-Ag), diamondlike carbon-platinum (DLC-Pt), and diamondlike carbon-silverplatinum (DLC-AgPt) thin films using a multicomponent target pulsed laser deposition process.Transmission electron microscopy of the DLC-silver and DLC-platinum composite films revealed that the silver and platinum self-assemble into nanoparticle arrays within the diamondlike carbon matrix. The diamondlike carbon-silver film possesses hardness and Young's modulus values of 37 GPa and 331 GPa, respectively. The diamondlike carbon-metal composite films exhibited passive behavior at open-circuit potentials. Low corrosion rates were observed during testing in a phosphate-buffered saline (PBS) electrolyte. In addition, the diamondlike carbon-metal composite films were found to be immune to localized corrosion below 1000 mV (SCE). DLC-silver-platinum films demonstrated exceptional antimicrobial properties against Staphylococcus bacteria. It is believed that a galvanic couple forms between platinum and silver, which accelerates silver ion release and provides more robust antimicrobial activity.Diamondlike carbon-silver-platinum films may provide unique biological functionalities and improved lifetimes for cardiovascular, orthopaedic, biosensor, and implantable microelectromechanical systems.

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“…The resulting release of reactive products of oxygen and lysosomal enzymes may cause accidental host tissue damage and local vascular insufficiency, thereby increasing the predisposition of osteomyelitis development. Also, some of the normal phagocytic processes are devoted to removal of the implant foreign material (particularly with metals, methylmethacrylate, and polyglycolic acid), thereby utilizing the energy and resources of the immune system that would normally be used to fight infection (146,147,184). Therefore, prosthetic implants not only provide a substrate for bacterial adherence but also limit the ability of the host to adequately deal with the infection.…”

Section: A Special Case: Prosthetic Joint Infectionsmentioning

confidence: 99%

Acute Septic Arthritis

2002

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Acute septic arthritis may develop as a result of hematogenous seeding, direct introduction, or extension from a contiguous focus of infection. The pathogenesis of acute septic arthritis is multifactorial and depends on the interaction of the host immune response and the adherence factors, toxins, and immunoavoidance strategies of the invading pathogen. Neisseria gonorrhoeae and Staphylococcus aureus are used in discussing the host-pathogen interaction in the pathogenesis of acute septic arthritis. While diagnosis rests on isolation of the bacterial species from synovial fluid samples, patient history, clinical presentation, laboratory findings, and imaging studies are also important. Acute nongonococcal septic arthritis is a medical emergency that can lead to significant morbidity and mortality. Therefore, prompt recognition, rapid and aggressive antimicrobial therapy, and surgical treatment are critical to ensuring a good prognosis. Even with prompt diagnosis and treatment, high mortality and morbidity rates still occur. In contrast, gonococcal arthritis is often successfully treated with antimicrobial therapy alone and demonstrates a very low rate of complications and an excellent prognosis for full return of normal joint function. In the case of prosthetic joint infections, the hardware must be eventually removed by a two-stage revision in order to cure the infection

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Lack of immune response to methyl methacrylate in lymphocyte cultures

Cited by 45 publications

References 12 publications

Cellular profile and cytokine production at prosthetic interfaces

Cellular profile and cytokine production at prosthetic interfaces

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Acute Septic Arthritis

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