Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination

Abstract

Demand for rabies hyperimmunoglobulin has increased recently, requiring optimization of vaccination schemes for immunized plasma donors. Possible resemblance of rabies vaccine to blood group antigens and consequential association of the immune response to rabies vaccine and blood group or corresponding isoantibodies has not yet been investigated. We analyzed antirabies antibodies after rabies vaccination and ABO blood group in 142 individuals, and isoantibody titers in 92 of those individuals. We did not find any correlation of the immune response with blood group or isoantibody levels. There was also no correlation with the sex of individuals, but there was a weak correlation between age and rabies-specific antibody level. Rabies vaccination schemes for immunized donors cannot be optimized on the basis of blood groups or isoantibody titers.

SARS-CoV-2 vaccination, ABO blood group and risk of COVID-19: population-based cohort study

“…6 The current study is the first to explore effect modification of O blood group on vaccine effectiveness against SARS-CoV-2 infection or related illness. Just as we found no effect modification, prior research on the smallpox vaccine suggested no differences in 'vaccine success' by ABO blood group, 14 nor for influenza A, 15 rabies 16 and cholera 17 vaccines. Thus, if O blood group is somehow protective against SARS-CoV-2 infection or illness, it is unlikely to generate any additive benefit to that conferred by available mRNA and Ad-V vaccines.…”

Imunogenicidade de doses dobradas da vacina contra o vírus da hepatite B em pacientes cirróticos em lista de espera para transplante de fígado: estudo clínico randomizado

“…Estudo com vacina de raiva já avaliou, mas não demonstrou relação entre sua resposta e tipo sanguíneo. 74 Em nosso trabalho, o tipo sanguíneo O foi um fator de melhor resposta quando comparado ao grupo A e B. Avaliação com o tipo AB não foi possível, pelo pequeno número de pacientes com este tipo sanguíneo.…”