Lack of Impact of Hepatitis C Virus Coinfection in End-Stage Renal Disease Patients With Hepatitis B Virus Infection

Moutinho, Renata; Perez, Renata M.; Pace, F.; Ferreira, Andressa Coelho; Cendoroglo, Miguel; Medina-Pestana, J.O.; Lanzoni, Valéria Pereira; Silva, A.E.B.; Ferraz, M.L.G.

doi:10.1016/j.transproceed.2005.03.002

Cited by 4 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 HBV/HCV coinfection was related to a longer time on hemodialysis, longer duration of infection and history of blood transfusion. 14 Improved infection control and the availability of vaccines have reduced the incidence of HBV infection among hemodialysis patients from 3% in 1980 to 0.1% in 1993 in the United States and has remained stable in the past decades. 15,16 However, dialysis patients have impaired antibody response to vaccines.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B and C among Hemodialysis Patients of Tripura, India

Bhaumik¹,

Debnath²

2011

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

Introduction: Hemodialysis is a trusted intermediate procedure for management of chronic kidney disease (CKD) patients. As such CKD is an immune-deficient state, hence, they may be infected by hepatitis B virus (HCV) and hepatitis C virus (HCV) during hemodialysis. Eventually, HBV and HCV infection is an important cause of morbidity and mortality among patients of hemodialysis. Prevalence of HBV and HCV infection among hemodialysis patients is highly variable. Aim of the study:This study was designed to see the prevalence of HBV and HCV among hemodialysis patients of Tripura, India and to evaluate the mode of transmission. Materials and methods:This is a single center prospective study among the patients who has come for hemodialysis at the Dialysis Unit of Agartala Government Medical College and Govinda Ballav Pant Hospital during the period of January 2011 to June 2011.Results: Male predominance has been observed among the hemodialysis patients and mean age of the patients was 48.16 years. New HBV infection was found in 5.5% of the hemodialysis patients (cumulative 7.3%) and 10.9% (cumulative 12.12%) of patients got new HCV infection during hemodialysis. Coinfection with both HBV and HCV was found among 1.2% of hemodialysis patients. History of blood transfusion was found in 100% of newly infected HBV and HCV patients. Discussion:The evaluation suggests that blood transfusion may be the single most important risk factor for HBV and HCV infection among hemodialysis patients. Newer methods of screening of blood in blood bank like nucleic acid test or polymerase chain reaction amplification of nucleic acids should be adopted to prevent HBV and HCV transmission

show abstract

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B and C among Hemodialysis Patients of Tripura, India

Bhaumik¹,

Debnath²

2011

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

show abstract

“…More importantly, there was no significant difference in the 10-year survival rate of patients with HBV-HCV coinfection and those with single HBV infection. Similarly, Moutinho et al [26] have reported that HBV and HCV coinfection did not result in more severe forms of liver diseases determined by liver histology than HBV single infection in hemodialysis patients. …”

Section: Discussionmentioning

confidence: 91%

“…It has been well documented that HBV and HCV coinfection causes more severe liver damage when compared with single HBV infection in nonuremic patients [12,13,14,25]. In contrast, the impact of HBV and HCV coinfection in comparison with HBV infection alone on the severity of liver disease determined by liver histology in hemodialysis patients is not significantly different [26]. However, data on the long-term outcome of HBV and HCV coinfection in comparison with single HBV infection in hemodialysis patients are lacking.…”

Section: Discussionmentioning

confidence: 99%

Comparable Ten-Year Outcome in Hemodialysis Patients with Hepatitis C Virus and Hepatitis B Virus Coinfection and Single Hepatitis B Virus Infection

Lee

Li²,

Chen³

et al. 2011

Blood Purif

View full text Add to dashboard Cite

Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection in comparison with single HBV infection causes more severe liver disease in nonuremic population. The long-term impact of HBV/HCV coinfection on severity of liver diseases and patient survival in hemodialysis patients is unclear. Forty-eight HBV-positive patients and 19 HBV/HCV-positive patients were followed up from February 1996 to September 2006. During 10-year follow-up, there was no difference in acute hepatitis episodes, abnormal serum alanine aminotransferase period, occurrence of cirrhosis and hepatocellular carcinoma, and patient survival between the two groups. The serum HBV DNA levels in HBV/HCV-positive patients were significantly lower than those in HBV-positive patients during the first 27-month follow-up. In conclusion, HCV infection suppresses the serum HBV DNA level in hemodialysis patients. Nevertheless, HBV/HCV coinfection in comparison with single HBV infection does not cause more severe liver diseases or reduce patient survival in hemodialysis patients during 10-year follow-up.

show abstract