Abstract:Aim: Wood creosote (WC), an over-the-counter (OTC) drug, has been used as an anti-diarrheal agent for many years; however, its safety in combination with other drugs has not been adequately investigated. The current study was conducted to evaluate whether WC may cause drug interactions through the inhibition of cytochrome P450 (CYP). Methods: The inhibitory effects of WC on ethoxyresorufin O-deethylation, paclitaxel 6α-hydroxylation, S-warfarin 7-hydroxylation, S-mephenytoin 4 0 -hydroxylation, bufuralol1 0 -h… Show more
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