Lack of interaction between hepatitis C virus and alcohol in the pathogenesis of cirrhosis. A statistical study

Alemy-Carreau, Muriel; Durbec, Jean-Pierre; Giordanella, Jacques; Rousseau, Simone; Blanc, Georges; Monges, D.; Perreard, M.; Harlé, J.-R.; Weiller, Pierre Jean; Gérolami, A

doi:10.1016/s0168-8278(96)80230-3

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…We found synergism between alcohol and HCV infection in causing HCC. This is in concordance with the results of a case–control study on the risk of HCC from Italy 41 but in contrast with the findings of two case–control studies on the risk of liver cirrhosis 42,43 …”

Section: Discussionsupporting

confidence: 87%

“…This is in concordance with the results of a casecontrol study on the risk of HCC from Italy 41 but in contrast with the findings of two case-control studies on the risk of liver cirrhosis. 42,43 The available biological data also support synergism between alcohol and HCV. The patients with alcoholic liver disease who are positive for HCV RNA have been shown to have higher alanine aminotransferase levels and higher scores of the histology activity index than HCV RNA negative patients.…”

Section: Discussionmentioning

confidence: 88%

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Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: A case–control study of 213 hepatocellular carcinoma patients from India

Kumar¹,

Kumar²,

Hissar³

et al. 2007

J of Gastro and Hepatol

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Infection with HBV and HCV are the major risk factors for the development of HCC in Indian patients. Presence of HBV antibodies even in the absence of HBsAg conferred increased risk for HCC in the presence or absence of cirrhosis. Anti-HCV positivity in the absence of HCV RNA conferred no increased risk. HCV RNA positivity and heavy alcohol use significantly increased the risk of HCC among cirrhotic patients, but not non-cirrhotic patients.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 88%

Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: A case–control study of 213 hepatocellular carcinoma patients from India

Kumar¹,

Kumar²,

Hissar³

et al. 2007

J of Gastro and Hepatol

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“…33 Likewise, another report through the use of a hierarchical statistical model found that alcohol and HCV were additive, rather than multiplicative, in the development of cirrhosis. 34 Small population samples were examined in these studies.…”

Section: Discussionmentioning

confidence: 99%

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection

et al. 1998

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In patients with chronic hepatitis C, alcohol consumption has been proposed as a risk factor for the progression of liver disease; however, evidence for this remains conflicting. Two hundred thirty-four anti-hepatitis C virus (HCV)-positive patients who had a liver biopsy performed within the past 24 months were studied. Demographic data and information on risk factors were recorded. A detailed lifetime alcohol consumption history was obtained. Viral studies included HCV viral titer and HCV genotype. Mean age (؎ SEM) of the group was 40.8 ؎ 0.7 years. One hundred sixty-six (71%) were male. A risk factor for HCV infection was found in 195 patients (86%). Genotype distribution was: 1b: 22%; 1a: 15%; 1(nonsubtypable): 15%; 3a: 34%; and 2: 7%. Fifty (21%) patients had cirrhosis. Patients with cirrhosis were older (51.6 ؎ 1.8 years) than those with chronic hepatitis (37.6 ؎ 0.6 years; P ‫؍‬ .0001), were infected at an older age (25.9 ؎ 2.0 vs. 20.9 ؎ 0.6 years; P ‫؍‬ .001), and had a longer duration of infection After exposure to hepatitis C virus (HCV), over 70% of persons will fail to clear the infection and become chronic carriers. These individuals develop chronic hepatitis of varying severity.

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“…Although alcohol consumption appears to increase serum HCV RNA levels [9], the role of HCV RNA level in progression of fibrosis is unclear. A statistical study of a group of cirrhotic patients with a mean alcohol consumption of 148 g/day found the effects of hepatitis C and alcohol to be independent but additive [10]. Therefore, theoretical and observational arguments exist both for and against the role of alcohol in increasing fibrosis among chronic hepatitis C patients.…”

Section: Introductionmentioning

confidence: 99%

Positive CAGE Screen Correlates with Cirrhosis in Veterans with Chronic Hepatitis C

Kamal

Cheung

2007

Dig Dis Sci

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The current study examines the relationship between problem alcohol use and severity of liver disease by self-administered questionnaires using both the CAGE questionnaire and beverage-specific quantity-frequency questions. The cohort consisted of 38 patients with cirrhosis (10 with decompensated liver disease) and 62 with mild fibrosis (stage 0-1), of comparable mean age and estimated duration of infection. Although mean alcohol consumption was similar in both groups, a positive CAGE screen (defined as two or more affirmative answers) was significantly more common among cirrhotics (OR = 5.24; 95% CI, 1.78-15.39) and tended to be associated with decompensated liver disease (OR = 13.3; 95% CI, 0.67-256) among cirrhotics. In multivariate analysis, only inflammatory grade on liver biopsy (OR = 67.7; 95% CI, 10.6-431) and positive CAGE score (OR = 8.09; 95% CI, 1.15-57.1) were independent predictors of cirrhosis. These findings suggest that the CAGE questionnaire predicts advanced liver disease better than daily or lifetime drinking measures.

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Lack of interaction between hepatitis C virus and alcohol in the pathogenesis of cirrhosis. A statistical study

Cited by 14 publications

References 13 publications

Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: A case–control study of 213 hepatocellular carcinoma patients from India

Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: A case–control study of 213 hepatocellular carcinoma patients from India

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection

Positive CAGE Screen Correlates with Cirrhosis in Veterans with Chronic Hepatitis C

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