Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

Natphopsuk, Sitakan; Settheetham-Ishida, Wannapa; Settheetham, Dariwan; Ishida, Takafumi

doi:10.7314/apjcp.2015.16.5.1935

Cited by 6 publications

(10 citation statements)

References 18 publications

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“…Another more recent meta-analysis revised and updated the data of the Chinese population and found a significant association between GSTM1 null polymorphisms and cervical cancer in that population (Sun and Song, 2016). Disagreement between published results can be explained mainly by the different frequencies of this polymorphism in different populations, which can vary from 26% in Africans to 53% in Caucasians (Natphopsuk et al, 2015). Additionally, other factors could be associated with cancer development, such as lifestyle and exposition to different environmental xenobiotics.…”

Section: Discussionmentioning

confidence: 97%

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Research Article Null polymorphisms in GSTT1 and GSTM1 genes and their associations with smoking and cervical cancer

Tacca¹,

Lopes²,

Vilanova-Costa³

et al. 2019

Genet. Mol. Res.

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Human papillomavirus (HPV) infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases (GST) are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in women with cervical cancer and in a control group, as well as to determine possible associations between such polymorphisms, cigarette smoking and the prognosis of cervical cancer. The series comprised 135 cervical cancer patients and 100 women without cancer. Genotypes were ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (1): gmr18067 A.L.M. Tacca et al. 2 investigated by PCR. The results were compared using the Chisquare test or Fisher's exact test, and survival analysis by Kaplan-Meier test and Log-rank. Among the cases, the frequency of GSTM1 gene null polymorphism was 22.2%, and for the GSTT1 gene it was 48.5%. Among the controls, the frequency of the GSTM1 gene null polymorphism was 45.0%, while for GSTT1 it was 56.0%. A significant association was found between smoking and cervical cancer (P= 0.0062; OR = 2.16). Differently from GSTM1, the GSTT1 null polymorphism was not associated with cervical cancer risk in this study. The GSTT1 null genotype was significantly associated with worse prognosis. The overall survival rate for the cervical cancer group was 78.5%, and when stratified by genotypes, survival was higher in patients presenting at least one of the alleles, GSTT1 or GSTM1, indicating a higher risk of death for those presenting dual nullity (P= 0.031; RR = 2.458).

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Section: Discussionmentioning

confidence: 97%

“…A recent study developed in Thailand concluded that deletion of GSTM1 is not a risk factor for cervical cancer. This study seems to present higher accuracy, since not only the null genotype for GSTM1 was studied but also the heterozygous variables for this gene (Natphopsuk et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Research Article Null polymorphisms in GSTT1 and GSTM1 genes and their associations with smoking and cervical cancer

Tacca¹,

Lopes²,

Vilanova-Costa³

et al. 2019

Genet. Mol. Res.

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“…21 studies of GSTM1 polymorphisms (2,250 CC cases and 3,025 controls) [6,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] , 17 studies of GSTT1 polymorphisms (1,704 CC cases and 2,060 controls) genotypes [6, 11-13, 15-17, 20-24, 26-30] , and 9 studies of GSTM1-GSTT1 interaction analyses (1,046 CC cases and 1,319 controls) [6,11,12,15,16,24,26,28] were included in our meta-analysis. The characteristics of the studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Liu¹,

Zeng²,

Ma³

et al. 2017

ijSciences

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Objective: To study the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer (CC) risk, and explore genetic-environmental interactions. Methods: After a systematic literature search, all relevant studies entailing the association between GST polymorphisms and CC were included. The pooled odds ratio (OR) was used for analysis of the results and corresponding 95% confidence intervals (CI) were estimated. Results: A total of 23 case-control studies were included in the meta-analysis of GSTM1 (2,250 CC cases and 3,025 controls) and GSTT1 (1,704 CC cases and 2,460 controls) genotypes. For the GSTM1 polymorphisms, the null genotype of GSTM1 was associated with an increased CC risk for the total population (OR=1.57, 95% CI=1.25-1.98). A similar association was found in China (OR=2.34, 95% CI=1.56-3.52), India (OR=2.02, 95% CI=1.43-2.83), Pakistan (OR=5.52, 95% CI=2.34-13.07), Serbia (OR=1.73, 95% CI=0.68-4.39) and Kazakhstan (OR=6.5, 95%CI=2.25-18.81), but was not noted for others countries. Regarding human papilloma virus (HPV) infection, moderately but significantly increased risk of the null GSTM1 genotype was found in HPV-positive patients (OR=2.59, 95% CI=1.57-4.27). For the GSTT1 polymorphisms, the null GSTT1 genotype was associated with increased CC risk in the total population (OR=1.44, 95% CI=1.07-1.93). Regarding ethnic stratification, a significantly increased risk of the null GSTT1 genotype was found in Kazakhstan (OR=3.99, and Brazil (OR=4.58, 95% CI=2.04-10.28). With respect to smoking, the two aspects of the analysis above were not significantly associated with CC risk in smokers or non-smokers, respectively. For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk for the total population (OR=1.62, 95% CI=1.14-2.29). Conclusion: This meta-analysis provided sufficient evidence that the null genotype of GSTM1, or GSTT1 and the dual-null genotypes of GSTM1/GSTT1 are associated with CC.

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“…It is believed that individuals with the GSTM1 null genotype lack the functional ability to detoxify the ultimate form of carcinogens and are, therefore, susceptible to cancer in various organs (including the lung, bladder, oral and nasopharynx) (Schnakenberg et al, 2000;Shield PG., 2002;Tiwawech et al, 2005;Liu et al, 2014;Zakiullah et al, 2015). Results of many other studies dealing with the association between GSTM1 polymorphism in some of these cancers have, however, proven contradictory (Tanimoto et al, 1999;Hahn et al, 2002;Natphopsuk et al, 2015). Geographical and ethnic differences as well as the method of genotypic detection may be responsible for the apparently conflicting data.…”

Section: Preliminary Study Of the Gstm1 Null Polymorphism And History Of Tobacco Smoking Among Oral Cancer Patients In Northeastern Thailmentioning

confidence: 99%

“…GSTM1 genotype was determined by the two independent PCR assays described by Natphopsuk et al (2015). To identify the GSTM1 null allele, a short-PCR amplification (Tiwawech et al, 2005) was performed using a primer pairs (5'-GAA CTC CCT GAA AAG CTA AAG C-3' and 5'-GTT GGG CTC AAA TAT ACG GTG G-3'); an amplification of the β-globin was used as an internal control.…”

Section: Detection Of Gstm1 Polymorphismmentioning

confidence: 99%

Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand

Natphopsuk¹,

Settheetham-Ishida²,

Phuthong³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Risks with GSTM1 genotypes and potential roles of smoking in the susceptibility to oral squamous cell carcinoma (OSCC) were studied in Northeastern Thailand. Study subjects were 79 histologically-confirmed OSCC cases (31 men, 48 women) and 79 age-and sex-matched healthy controls ranging in age from 25 to 84 years. GSTM1 genotyping was achieved by two independent PCR assays. The GSTM1 null allele and the homozygous genotype did not increase risk of OSCC vs the wild type allele and the remaining genotypes. When the focus was on the smoking habit, male subjects who smoked ≥10 or ≥35 years were at significantly increased risk for OSCC with adjusted ORs of 4.88 [95%CI, 1.41-16.87, p=0.012] or 4.94 [95%CI, 1.62-15.12, p=0.005], respectively. A higher risk for OSCC was found for smoking amount; those who smoked >5 or >10 pack-years were at a higher risk with adjusted OR of 4.46 [95%CI; 1.45-13.74, p=0.009] or 3.89 [95%CI; 1.34-11.28, p=0.012], respectively. There are certain smoking patterns that give greater risks and thus both smoking duration and pack-years should be taken into consideration in tobacco related cancer prevention.

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Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

Cited by 6 publications

References 18 publications

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand

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