Lack of Prognostic Significance of SOCS-1 Expression in Colorectal Adenocarcinomas

Abstract

Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.

Tumour-promoting role of SOCS1 in colorectal cancer cells

“…Nonetheless, low SOCS1 expression in cancer specimens showed a weak but significant correlation with lymph node and distant metastasis, and tumour stages of the disease ( Table 1 ). However, in line with Ayyildiz et al previous report 23 , our analyses failed to reveal a positive correlation between high SOCS1 mRNA levels in CRC tumours and better overall patient survival, even upon CRC patient stratification according to stages ( Fig. 1E ).…”

“…Nonetheless, high SOCS1 protein level was still noted in 63% of advanced stage IV CRC tumours. Likewise, Ayyildiz et al observed positive expression of SOCS1 in CRC tissues in nearly half of the cases by immunohistological analysis, but no association between SOCS1 protein level and clinicopathologic tumour characteristics 23 . Conflicting with a dominant tumour suppressor role for SOCS1 in CRC, elevated SOCS1 protein levels in CRC tumours did not predict better patient survival 23 .…”

“…Notably, CIMP colorectal tumours are associated with specific genetic features and poor clinical outcomes 20 21 , but SOCS1 methylation in CIMP CRCs has been linked to better overall patient survival than those without 18 . Only two recently published studies have so far probed the abundance of SOCS1 mRNA or protein in relatively small cohorts of human CRC samples 22 23 . Their findings are somewhat contradictory.…”

RETRACTED ARTICLE: Serum levels of PTEN mRNA in colorectal cancer: a case-control study

“…Metastasis is a major cause for CRC-related deaths, including liver metastasis and lymph node metastasis [5,6]. Currently, treatments for CRC mainly consist of surgical resection, radiotherapy and chemotherapy [7]. What is more, a series of clinical examinations have been used for CRC screening, such as colonoscopy, fecal occult blood test and sigmoidoscopy [8,9].…”

A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses

“…All 40 genes, however, did not affect prognosis in patients with TP53 mutant cancer (Figure 6B , Supplementary Figure 1 ), demonstrating a dependence on TP53 mutational status. The genes selected using this method included NCOA3 [ 34 , 35 ], HOXA1 [ 36 ], FOLR1 [ 37 ], SOCS1 [ 38 ], and PIK4CA [ 39 ], which showed similar expression patterns related to survival in patients with cancer. This result suggested that our method was a relatively simple method for identification of genes functionally associated with the p53 pathway.…”