Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos

Dougherty, Robert M.; Stefano, Henry S. Di

doi:10.1016/0042-6822(66)90282-0

Cited by 95 publications

(37 citation statements)

References 10 publications

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“…Although it is usually assumed that these antigens are coded for in the genome of the virus, alternative explanations may exist. For instance, it has been suggested that the common complement-fixing antigen of the avian leucosis group of viruses could be a normal chick component (34).…”

Section: Discussionmentioning

confidence: 99%

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Lindenmann

Klein

1967

The Journal of Experimental Medicine

215

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A2G mice could be solidly immunized against the Ehrlich ascites tumor by single intraperitoneal injections of homogenized and lyophilized tumor cells which had been infected with oncolytic strains of influenza A virus. Similar homogenates from noninfected tumor cells were not immunogenic, even when mixed with egg-grown virus. The immunizing principle in viral oncolysates could not be separated from the oncolytic virus by differential centrifugation or adsorption to and elution from red cells. It could be inhibited by antibody raised in rabbits against the egg-grown oncolytic virus. This reaction showed serologic specificity. Thus, the immunogenicity of an oncolysate produced with the WSA strain of neurotropic influenza virus could be inhibited by rabbit anti-WSA, but not by rabbit antibody to the TUR strain of fowl plague virus. Conversely, the immunogenicity of an oncolysate prepared with the TUR strain could be inhibited by rabbit anti-TUR, but not by anti-WSA. When mice were preimmunized (primed) with egg-grown WSA virus, their antitumor response to a later injection of WSA oncolysate was of the anamnestic type. Priming with egg-grown influenza B virus had no such effect. It was concluded that the immunogenicity of certain host cell components was greatly increased by incorporation into the makeup of the oncolytic virus.

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Section: Discussionmentioning

confidence: 99%

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Lindenmann

Klein

1967

The Journal of Experimental Medicine

215

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“…(i) The presence of an antigen that crossreacts with antibody against the ALV group-specific antigen (13); (ii) the synthesis of a small number of apparently noninfectious C-type virions in the pancreas and liver of leukosis-free embryos (15) and in the pancreas and ovary of healthy adult hens (16); (iii) the helper function without which RSV(0) cannot replicate (13); (iv) the production of RAV (Rous-associated virus)-60 that is induced by infection with RSV (17), and probably by the same mechanism, the often noted. contamination of pure ALV stocks by other leukosis viruses; (v) by Dr. R. Friis (0 = no gs-antigen detected).…”

Section: Discussionmentioning

confidence: 99%

Widespread Presence, in Chickens, of DNA Complementary to the RNA Genome of Avian Leukosis Viruses

Baluda¹

1972

Proc. Natl. Acad. Sci. U.S.A.

139

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“…A major consideration in our studies was the possibility that the immunity was provided by MuLV antigen in the fetal cell preparations rather than by a cross-reactive embryonic specific antigen. This is especially true since antigen similar to the gs antigen of avian leukosis virus has been found in virusfree chicken embryo cells (22 (19) have found that all naturally occurring MuLV isolated from BALB/c and other mouse strains are of the Gross or AKR virus serotype. Thus, any virus present in the embryo cell preparations of our study probably has no neutralizing or cross-reacting activity with the RLV since it is of the FMR serotype.…”

Section: Discussionmentioning

confidence: 99%

“…The recovery of spleen cells of mice infected with RLV for 22 and 28 days was markedly depressed (approx. 60 and 49% of normal) when the cells were implanted in embryo-primed recipients.…”

Section: Hemolytic Plaque-forming Cellsmentioning

confidence: 99%

Suppressive Effect of Immunization with Mouse Fetal Antigens on Growth of Cells Infected with Rauscher Leukemia Virus and on Plasma-Cell Tumors

Hanna¹,

Tennant²,

Coggin

1971

Proc. Natl. Acad. Sci. U.S.A.

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The recovery of spleen cells infected with Rauscher leukemia virus (RLV) and grown in Millipore diffusion chambers, the development of RLV-induced splenomegaly, and the cumulative mortality from a transplanted ascites plasma-cell tumor were all suppressed in young adult BALB/c male mice previously primed at 3-weekly intervals with x-irradiated, syngeneic Numerous reports have suggested that fetal cells have antigens that cross-react with specific transplantation antigens in tumor cells (1-6). Although the overall concept is unclear, it is proposed that, upon neoplastic transformation, cells of mature individuals express activity of gene groups that were functional during fetal life but were later repressed. Thus it is possible that during the process of oncogenesis there is a derepression of fetal genes, resulting in the de novo synthesis of antigenic substances detectable as transplantation antigens of tumors. In humans, three classes of embryonal antigens of tumor cells have been described. Gold and Freeman (7) found that fetal gut, liver, and pancreas possess antigen that cross-reacts with specific tumor antigen of the digestive system. These components were named "carcinoembryonic" antigens of the human colon tumor. Abelev (8) mid-gestation, x-irradiated, syngeneic or xenogenic mouse fetus possessed cytostatic antibody to SV40 tumors and were immune to SV40 tumor transplant. Subsequent studies showed that unirradiated fetal cells were poorly immunogenic, differentiated rapidly, and produced embryomas at the site of inoculation (11). Cytotoxic alloantibody against mouse ova was also active against SV40 tumor cells, and immunofluorescence studies revealed that methylcholanthrene-induced

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Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos

Cited by 95 publications

References 10 publications

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Widespread Presence, in Chickens, of DNA Complementary to the RNA Genome of Avian Leukosis Viruses

Suppressive Effect of Immunization with Mouse Fetal Antigens on Growth of Cells Infected with Rauscher Leukemia Virus and on Plasma-Cell Tumors

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