Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Rasmi, Yousef; Mehraban, Kamal; Sadreddini, Masoud; Zeynalzadeh, Javad; Majidinia, Maryam; Seyyed-Mohammadzad, Mir-Hossein; Babazadeh, Homayoon

doi:10.5603/cj.2012.0086

Cited by 10 publications

(11 citation statements)

References 15 publications

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“…Therefore, the exact attribution of endothelial dysfunction and the factors that influence endothelial function in MVA is a subject of great interest for researchers in this field. In our previous studies, we investigated the various aspects of this subject and assessed different factors that may be involved in the pathogenesis of the MVA and we obtained attractive results, even offered a hypothesis in this area [21–24]. As a follow-up of our research chain about MVA, in this study we have addressed the involvement of angiogenesis and the levels of angiogenic factors in MVA.…”

Section: Discussionmentioning

confidence: 99%

Increased levels of Angiogenic Factors In Microvascular Angina

Roshani-Asl

Rasmi

Khadem-Ansari

et al. 2019

Medicine and Pharmacy Reports

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Background. Recent studies have suggested that angiogenic factors may affect vascular endothelial integrity. On the other hand, endothelial dysfunction is the main pathological mechanism in microvascular angina (MVA) or cardiac syndrome X. Therefore, we aimed to determine the levels of angiogenic factors in MVA patients. In addition, we investigated the effects of metoprolol, as a beta blocker agent, on the serum levels of these factors.Methods. Thirty patients with MVA (17 female/13 male; mean age: 55.53±9.18 years) and twenty healthy controls (14 female/6 male; mean age: 51.40±9.16 years) were enrolled.The serum amounts of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and tyrosine kinase-2 receptor (Tie-2) were measured in healthy controls, MVA patients at baseline and after metoprolol therapy (25 mg for one month) by enzyme-linked immunosorbent assay.Results. The levels of Ang-2 and Tie-2 were significantly higher in MVA patients at baseline in comparison with controls (Ang-2: 277.02±186.08 vs.164.46±49.83 ng/l, P=0.011; Tie-2: 28.97±18.85 vs. 14.90±4.05 ng/ml, P=0.002; respectively). But this difference in the Ang-1 levels was not significant (P=0.829). Additionally, the levels of angiogenic factors in MVA patients after metoprolol therapy were not significantly changed in comparison with the baseline status (P>0.05).Conclusion. Our results considered a possible role for angiogenic factors in the pathophysiology of MVA, which need ‎further investigation for elucidation. In addition, this study has not showed an effective role for metoprolol in changing the angiogenic factors levels as a therapeutic agent in MVA.

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Section: Discussionmentioning

confidence: 99%

Increased levels of Angiogenic Factors In Microvascular Angina

Roshani-Asl

Rasmi

Khadem-Ansari

et al. 2019

Medicine and Pharmacy Reports

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“…Oxidation of oxidation-sensitive substance like B-vitamins (eg. folic acid and B12), essential cofactors in homocysteine (Hcys)-methionine metabolism, cause hyperhomocysteinemia (32) and cellular immune activation found in coronary heart disease (31) as well as SCF (8). All the mentioned actions support IFN-γ role in inflammation, endothelial dysfunction and eventually atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Faramarz-Gaznagh

Rasmi

Khadem-Ansari

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundSlow coronary flow (SCF) is a coronary artery disorder characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. The pathophysiological mechanisms of SCF remain unclear. One of the possible mechanisms that may participate in the pathology of SCF is endothelial dysfunction related to the inflammatory process. Interferon gamma (IFN-γ) is an inflammatory cytokine that acts through its specific receptor composed of two subunits, IFN-γR1 and IFN-γR2. Transcriptional activity of the gene encoding these subunits influences IFN-γ activity. This study aimed to investigate the gene expression of IFN-γ receptor subunits in peripheral blood mononuclear cells (PBMC) from patients with SCF.MethodsThe study was performed with 30 patients (22 male/8 female) aged 35–76 (52.8±11.7 years) with SCF and 15 sex- (11 male/4 female), Body Max Index (BMI)- and age-matched (54.73±9.42 years) healthy subjects. Total mRNA was extracted from PBMC and was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). The relative expression values (2-ΔΔCt) between control and case groups were determined and the Mann-Whitney U test was used for statistical analysis.ResultsThere was a significant increase in the gene expression of IFN-γR1 in PBMC from SCF patients vs. controls (P< 0.0001); but the differences in IFN-γR2 gene expression were statistically insignificant between patient and control groups (P= 0.853).ConclusionsIt can be concluded that IFN-γ gene expression may influence the function of microvasculature and thereby contribute to the pathophysiology of SCF.

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“…We read the article "Lack of significant association between Helicob acter pylori infection and homocysteine levels in patients with cardiac syndrome X" written by Rasmi et al [1] with a great interest. The authors pointed to the possible relation between H.pylori infection and homocysteine (Hcy) levels in cardiac syndrome X (CSX).…”

Section: Helicobacter Pylori Infection and Homocysteine Levels In Patmentioning

confidence: 99%

Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Balta¹,

Çakar²,

Demırkol³

et al. 2013

Cardiol J

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Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Cited by 10 publications

References 15 publications

Increased levels of Angiogenic Factors In Microvascular Angina

Increased levels of Angiogenic Factors In Microvascular Angina

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

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