1965
DOI: 10.1016/0005-2787(65)90023-7
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Lack of specificity in the formation amino-acyl-sRNA as a possible source of coding errors

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Cited by 13 publications
(2 citation statements)
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“…The results described here for E. coli K12 system resemble the observation in the thermophilic system in that the isoleucyl-tRNA synthetases from Bacillus stearothermophilus as well as E. coli K12 give significant amounts of ATP-PP¡ exchange in the presence of not only L-isoleucine but also L-valine and L-leucine (Arca et al, 1965(Arca et al, , 1967. But they differ markedly in that at 75°L-valine (and L-leucine to a lesser extent) can be esterified to tRNA, presumably to tRNAIle.…”
Section: Discussionsupporting
confidence: 73%
“…The results described here for E. coli K12 system resemble the observation in the thermophilic system in that the isoleucyl-tRNA synthetases from Bacillus stearothermophilus as well as E. coli K12 give significant amounts of ATP-PP¡ exchange in the presence of not only L-isoleucine but also L-valine and L-leucine (Arca et al, 1965(Arca et al, , 1967. But they differ markedly in that at 75°L-valine (and L-leucine to a lesser extent) can be esterified to tRNA, presumably to tRNAIle.…”
Section: Discussionsupporting
confidence: 73%
“…2), and therefore decreased the frequency of coding errors. Conversely, a reduction in temperature increased the frequency of coding errors, an effect already documented (2,4,14). Temperature and pressure data are summarized in Fig.…”
Section: Pressure Effects On Polypeptide Synthesis Fronzmentioning
confidence: 95%