Lack of the Associations of the Polymorphisms in <scp>IGF</scp>2, <scp>MC</scp>4<scp>R</scp> and <scp>GNAS</scp> Genes with Reproduction Traits in Pigs and Imprinting Analysis of <scp>IGF</scp>2 Gene in Ovary and Cornus Uteri

Oczkowicz, Maria; Mucha, A.; Tyra, M.; Ropka‐Molik, Katarzyna; Piórkowska, Katarzyna

doi:10.1111/rda.12125

Cited by 7 publications

(4 citation statements)

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“…The identification of genes or genetic markers associated with growth, fat deposition and feed intake in pigs could have a great economic impact on pork production. Many polymorphic genes have been analyzed up to date including those for key hormones and their receptors (Hongyu et al, 2010;Yu et al, 2013;Oczkowicz et al, 2013;Huang and Wang, 2013;Ghaly and Al-Sowayan, 2014;Nanuwong and Bodhisuwan, 2014). The Melanocortin-4 Receptor (MC4R) is one of the most important signaling molecules involved in the conduct of the leptin signal and regulates energy homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Melanocortin-4 Receptor Gene on Growth and Meat Traits in Pigs Raised in Russia

Клименко

Усатов

Getmantseva

et al. 2014

American Journal of Agricultural and Biological Sciences

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Тhe Melanocortin-4 Receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R polymorphism (Asp298Asn) and growth and meat productive traits of pigs. The aim of this work was to determine frequencies of the MC4R/Taq I genotypes and alleles in Danish Landrace (LD), Canadian Landrace (LC) and crossbred pigs Danish Landrace × Canadian Landrace (LD × LC) in breeding Cent "Plemzavod Jubilee" (Tyumen) Russia and to estimate their associations with some growth and meat traits. The polymorphism was identified by PCR-RFLP method. The traits studied were: Number of days to 100-kg, Average Daily Gain (ADG), Backfat Thickness (BFT), average daily Feed Intake (FI) and Length of Body (LB). In the all test groups we found a higher frequency of G allele (0.71) compared with the A allele (0.29). The results of present study suggest that the MC4R gene contributes to Days to 100 kg, ADG and BF. The heterozygous genotype AG was favorable in LD breed. The significant effects of-1.43 (LD male) and-2.81(LD female) for Days to 100 kg and of+61.17 (LD male) and +26.3 (LD female) for ADG were calculated. The homozygous genotype GG was favorable in crossbred LD × LC. The significant effects of +74.2 for ADG and-1.5 for BF were calculated. Therefore, the data support a role for the MC4R Asp298Asn polymorphism in the genetic basis of economically important traits in pigs of Russia. Further research is needed to determine the effect of this gene on growth, meat and reproduction traits in pigs of different breeds and crosses.

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Section: Discussionmentioning

confidence: 99%

Effects of Melanocortin-4 Receptor Gene on Growth and Meat Traits in Pigs Raised in Russia

Клименко

Усатов

Getmantseva

et al. 2014

American Journal of Agricultural and Biological Sciences

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“…Multiple genes, including major genes and genes with moderate or minor effects, control meat quality. RN, RKAG3, RYR1, PHKG1, MC4R, and insulin-like growth factor 2 (IGF2) are the major genes reported to affect meat-quality traits (Milan et al, 2000;Barbut et al, 2008;Yu et al, 2008;Oczkowicz et al, 2013;Ma et al, 2014;Lu et al, 2018). In total, 30,580 quantitative trait loci (QTLs) were released for public access on the pig QTL database 1 , which reported 691 pig traits associated with meat quality.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study of Meat Quality Traits in a Three-Way Crossbred Commercial Pig Population

Gao

Li³

et al. 2021

Front. Genet.

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Meat quality is an important trait for pig-breeding programs aiming to meet consumers’ demands. Geneticists must improve meat quality based on their understanding of the underlying genetic mechanisms. Previous studies showed that most meat-quality indicators were low-to-moderate heritability traits; therefore, improving meat quality using conventional techniques remains a challenge. Here, we performed a genome-wide association study of meat-quality traits using the GeneSeek Porcine SNP50K BeadChip in 582 crossbred Duroc × (Landrace × Yorkshire) commercial pigs (249 males and 333 females). Meat conductivity, marbling score, moisture, meat color, pH, and intramuscular fat (IMF) content were investigated. The genome-wide association study was performed using both fixed and random model Circulating Probability Unification (FarmCPU) and a mixed linear model (MLM) with the rMVP software. The genomic heritability of the studied traits ranged from 0.13 ± 0.07 to 0.55 ± 0.08 for conductivity and meat color, respectively. Thirty-two single-nucleotide polymorphisms (SNPs) were identified for meat quality in the crossbred pigs using both FarmCPU and MLM. Among the detected SNPs, five, nine, seven, four, six, and five were significantly associated with conductivity, IMF, marbling score, meat color, moisture, and pH, respectively. Several candidate genes for meat quality were identified in the detected genomic regions. These findings will contribute to the ongoing improvement of meat quality, meeting consumer demands and improving the economic outlook for the swine industry.

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“…However, with the availability of pig whole-genome sequence data and the rapid development of molecular genetics, much progress has been made in untangling the molecular mechanisms that underlie meat quality traits. For example, it has been shown that the genes insulin-like growth factor 2 ( IGF2 ) [ 8 , 9 ], melano-cortin 4 receptor ( MC4R ) [ 9 ], protein kinase, AMP-activated, gamma 3 non-catalytic subunit ( PRKAG3 ) [ 10 ] and ryanodine receptor 1 ( RYR1 ) [ 11 ] have major effects on meat production and quality in pigs. Identification of these genes has greatly benefited the pig industry [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association analyses for meat quality traits in Chinese Erhualian pigs and a Western Duroc × (Landrace × Yorkshire) commercial population

et al. 2015

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BackgroundUnderstanding the genetic mechanisms that underlie meat quality traits is essential to improve pork quality. To date, most quantitative trait loci (QTL) analyses have been performed on F2 crosses between outbred pig strains and have led to the identification of numerous QTL. However, because linkage disequilibrium is high in such crosses, QTL mapping precision is unsatisfactory and only a few QTL have been found to segregate within outbred strains, which limits their use to improve animal performance. To detect QTL in outbred pig populations of Chinese and Western origins, we performed genome-wide association studies (GWAS) for meat quality traits in Chinese purebred Erhualian pigs and a Western Duroc × (Landrace × Yorkshire) (DLY) commercial population.MethodsThree hundred and thirty six Chinese Erhualian and 610 DLY pigs were genotyped using the Illumina PorcineSNP60K Beadchip and evaluated for 20 meat quality traits. After quality control, 35 985 and 56 216 single nucleotide polymorphisms (SNPs) were available for the Chinese Erhualian and DLY datasets, respectively, and were used to perform two separate GWAS. We also performed a meta-analysis that combined P-values and effects of 29 516 SNPs that were common to Erhualian, DLY, F2 and Sutai pig populations.ResultsWe detected 28 and nine suggestive SNPs that surpassed the significance level for meat quality in Erhualian and DLY pigs, respectively. Among these SNPs, ss131261254 on pig chromosome 4 (SSC4) was the most significant (P = 7.97E-09) and was associated with drip loss in Erhualian pigs. Our results suggested that at least two QTL on SSC12 and on SSC15 may have pleiotropic effects on several related traits. All the QTL that were detected by GWAS were population-specific, including 12 novel regions. However, the meta-analysis revealed seven novel QTL for meat characteristics, which suggests the existence of common underlying variants that may differ in frequency across populations. These QTL regions contain several relevant candidate genes.ConclusionsThese findings provide valuable insights into the molecular basis of convergent evolution of meat quality traits in Chinese and Western breeds that show divergent phenotypes. They may contribute to genetic improvement of purebreds for crossbred performance.Electronic supplementary materialThe online version of this article (doi:10.1186/s12711-015-0120-x) contains supplementary material, which is available to authorized users.

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Lack of the Associations of the Polymorphisms in IGF2, MC4R and GNAS Genes with Reproduction Traits in Pigs and Imprinting Analysis of IGF2 Gene in Ovary and Cornus Uteri

Cited by 7 publications

References 39 publications

Effects of Melanocortin-4 Receptor Gene on Growth and Meat Traits in Pigs Raised in Russia

Effects of Melanocortin-4 Receptor Gene on Growth and Meat Traits in Pigs Raised in Russia

Genome-Wide Association Study of Meat Quality Traits in a Three-Way Crossbred Commercial Pig Population

Genome-wide association analyses for meat quality traits in Chinese Erhualian pigs and a Western Duroc × (Landrace × Yorkshire) commercial population

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