“… 4-133 As mentioned above, due to the large number of papers being published daily, the decision was made not to update the search results before publication as this would significantly delay the guidance being available to readers. However, there were seven articles, 134 , 135 , 136 , 137 , 138 , 139 , 140 which were published after the search date and during the data extraction process that were felt to be of significant clinical importance. Further 55 articles 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 were identified and recommended by experts and via other searches and were included ...…”