Lack of tubal occlusion by intrauterine quinacrine and tetracycline in the primate

Zaneveld, L. J. D.; Goldsmith, A

doi:10.1016/0010-7824(84)90100-8

Cited by 15 publications

(3 citation statements)

References 5 publications

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“…Recently, Zaneveld and Goldsmith concluded that the animal models used for the study of quinacrine are not adequate for these purposes and that there are no animal models which are known to be appropriate [17]. As with other methods of fertility control, these answers are only going to come from clinical field trials.…”

Section: The Qinscrine Pellet Methodsmentioning

confidence: 97%

“…The potential toxic effects of quinacrine have prompted a search for other drugs that are equally effective in producing inflammation and fibrosis of Recent studies [17,19,20] indicate that tetracycline hydrochloride may be as effective as quinacrine in producing tubal closures when administered directly to the uterotubal junction. One study [19] has demonstrated that tetracycline when directly applied to the uterine lumen in rats resulted in morphologic changes similar quantitatively and qualitatively to that of quinacrine.…”

Section: Tetracycline As An Alternative Sclerosing Agentmentioning

confidence: 98%

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Studies of quinacrine and of tetracycline for non-surgical female sterilization

1987

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The transcervical quinacrine pellet method developed by Zipper and co-workers is potentially a much needed safe, inexpensive, and effective non-surgical method of female sterilization. This method utilizes an intrauterine device inserter to deposit 250 mg of quinacrine hydrochloride as pellets in the uterine cavity. No complications or side effects, other than temporary pain and oligomenorrhea, have been reported. Tetracycline has an established track record for safety. It also has been reported to have properties similar to quinacrine as a sclerosing agent, with potential as a non-surgical method using the quinacrine insertion technique. To expand the experience with quinacrine and to study tetracycline as an alternative, studies were undertaken under the auspices of the Indian Rural Medical Association in Calcutta, India. During the period 14 August, 1979 to 28 June, 1984, 414 women received three insertions of 200 mg of quinacrine. There were 29 failures and a three-year life table failure rate of 8.5. During the period 25 April, 1984 to 28 December 1984, 55 women received three insertions of 200 mg of tetracycline. By 1 June, 1986 there were 32 failures among the 55 cases for a failure rate of 58%. A more recent study using a single dose of 1000 mg of tetracycline also produced unacceptably high failure rates.

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Section: The Qinscrine Pellet Methodsmentioning

confidence: 97%

Section: Tetracycline As An Alternative Sclerosing Agentmentioning

confidence: 98%

Studies of quinacrine and of tetracycline for non-surgical female sterilization

1987

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“…Numerous agents, supposed to sclerose the tubal lumen and/or the uterine cornua and/or the uterine cavity itself, have been tried: quinacrine, 28 quinacrine and tetracycline 29 with "inacceptably high failure rates," 30 phenol atrabine paste, 31 and bismuth polyurethane. 32 Most of these compounds were tested on a large scale in developing countries for campaigns of voluntary female sterilization.…”

Section: Sclerosing Agentsmentioning

confidence: 99%

Fallopian Tube Catheterization for Sterilization

Maubon¹,

Thurmond²,

Laurent³

et al. 2000

Semin intervent Radiol

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The evolution of methods for female sterilization

Wilson¹

1995

Intl J Gynecology & Obste

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Methods for the sterilization of women by occlusion of the Fallopian tubes have evolved by changes in the approaches to the tubes and trials of various methods for occluding the tubal lumen. Approaches to the tube have included: the anterior abdominal wall routes by laparotomy, minilaparotomy and laparoscopy; a vaginal approach through the posterior vaginal fornix; and transcervical approaches, either blind, or via the hysteroscope. Methods for obtaining tubal occlusion have included: excision and suture techniques; electrocautery; clips and rings; intratubal occlusive devices and chemicals introduced into the tubal lumen. The development of each of the approaches to the tube and of the methods for obtaining tubal occlusion are discussed.

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Lack of tubal occlusion by intrauterine quinacrine and tetracycline in the primate

Cited by 15 publications

References 5 publications

Studies of quinacrine and of tetracycline for non-surgical female sterilization

Studies of quinacrine and of tetracycline for non-surgical female sterilization

Fallopian Tube Catheterization for Sterilization

The evolution of methods for female sterilization

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