Lack of vasopressin expression in malignant melanomas

Aroni, Kyriaki; Charitopoulos, Konstantinos; Ac, Lazaris; Davaris, P

doi:10.1097/00008390-200012000-00004

Cited by 1 publication

(1 citation statement)

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“…Investigating the possible expression of vasopressin in both melanoma cells and in normal human skin melanocytes, Aroni et al [ 219 ] concluded that vasopressin does not play any role in the pathophysiology of this tumor.…”

Section: Neurohormones and Melanomamentioning

confidence: 99%

Neuroendocrine Factors in Melanoma Pathogenesis

Scheau

Drăghici

Ilie

et al. 2021

Cancers

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Melanoma is one of the most aggressive skin cancers with a sharp rise in incidence in the last decades, especially in young people. Recognized as a significant public health issue, melanoma is studied with increasing interest as new discoveries in molecular signaling and receptor modulation unlock innovative treatment options. Stress exposure is recognized as an important component in the immune-inflammatory interplay that can alter the progression of melanoma by regulating the release of neuroendocrine factors. Various neurotransmitters, such as catecholamines, glutamate, serotonin, or cannabinoids have also been assessed in experimental studies for their involvement in the biology of melanoma. Alpha-MSH and other neurohormones, as well as neuropeptides including substance P, CGRP, enkephalin, beta-endorphin, and even cellular and molecular agents (mast cells and nitric oxide, respectively), have all been implicated as potential factors in the development, growth, invasion, and dissemination of melanoma in a variety of in vitro and in vivo studies. In this review, we provide an overview of current evidence regarding the intricate effects of neuroendocrine factors in melanoma, including data reported in recent clinical trials, exploring the mechanisms involved, signaling pathways, and the recorded range of effects.

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Section: Neurohormones and Melanomamentioning

confidence: 99%