Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects

Epstein, Jennifer A.

doi:10.1176/appi.ajp.163.10.1784

Cited by 362 publications

(163 citation statements)

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“…However, their role has not been fully understood. To date, a couple of studies have demonstrated associations between depression and reduced neural responses during the viewing of pleasant facial expressions and words (Epstein et al, 2006;Monk et al, 2008;Surguladze et al, 2005) and during the sight and taste of pleasant chocolate stimuli (McCabe et al, 2009;McCabe et al, 2012). These findings point to the general nature of reduced reward responsiveness in depression, beyond monetary rewards.…”

Section: Social Rewards In Depressionmentioning

confidence: 97%

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Brinkmann

Franzén

2017

International Journal of Psychophysiology

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The present study extends past research about reduced reward responsiveness in depression by assessing effort-related cardiovascular responses during anticipation of a social reward. Dysphoric (i.e., subclinically depressed) and nondysphoric participants worked on a cognitive task. Half the participants in each group expected the possibility to subscribe to a social exchange internet site. Effort mobilization during task performance was assessed by participants' cardiovascular reactivity. Confirming the predictions, nondysphoric participants in the social-reward condition had higher reactivity of pre-ejection period, systolic blood pressure, and heart rate, compared to the other three cells. In contrast, dysphoric participants' cardiovascular reactivity was generally low. These findings indicate that social-reward function is indeed impaired in subclinical depression. Implications for social punishment are discussed.

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Section: Social Rewards In Depressionmentioning

confidence: 97%

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Brinkmann

Franzén

2017

International Journal of Psychophysiology

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“…Functional neuroimaging studies in MDD have consistently indicated hypoactivation in reward-processing regions, including the dorsal and ventral striatum [210-214] and a host of other reward structures, including the medial prefrontal cortex [215,216], the pregenual and subgenual anterior cingulate, and the medial frontal gyrus [217,218]. …”

Section: Reviewmentioning

confidence: 99%

“…Reduced mesolimbic activity in MDD has been found during reward anticipation and outcomes in both adults and children [210,219-227] and during reward learning [206]. For example, Smoski et al .…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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“…It has been proposed that the putative neural substrate of anhedonia may involve the dysfunction of a dopaminergic reward circuit. 17,18 However, only a limited number of neuroimaging studies have specifically attempted to confirm this hypothesis. To date, functional neuroimaging studies of anhedonia have focused exclusively on clinical populations, either SZ 19 or MDD.…”

Section: Introductionmentioning

confidence: 99%

“…To date, functional neuroimaging studies of anhedonia have focused exclusively on clinical populations, either SZ 19 or MDD. 17,18,20,21 For example, Keedwell et al (2005) linked the ventromedial prefrontal cortex (VMPFC) and the ventral striatal activity to anhedonia severity in MDD. Although these results have provided significant advancements in the neural characterization of anhedonia, it remains difficult to delineate clearly cerebral dysfunctions associated specifically with anhedonia from other dimensions of the illness.…”

Section: Introductionmentioning

confidence: 99%

Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects

et al. 2007

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Anhedonia, the reduced capacity to gain pleasure from pleasurable experiences, is a key symptom of major depression and schizophrenia. Reduced hedonic capacity can also be measured as an enduring trait in non-clinical subjects. Such altered hedonic capacity is likely the result of a basic neuropsychophysiological dysfunction and a vulnerability marker that potentially precedes and contributes to the liability of developing psychiatric disorders. The characterization of the structural and functional neural correlates of trait anhedonia in nonclinical individuals may provide new insights for the early detection of such psychiatric diseases. Twenty-nine non-clinical subjects were scanned at the Montreal Neurological Institute. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale. Semi-automated and automated structural MRI segmentation techniques were used to explore structural correlates of trait anhedonia. Seventeen of the 29 subjects also underwent a functional imaging task where responses to the viewing of affective stimuli were examined to identify the functional correlates of trait anhedonia. Trait anhedonia was inversely related to anterior caudate volume, but positively related to ventromedial prefrontal cortex activity during the processing of positive information. These findings may reflect a specific kind of vulnerability for the development of psychiatric affective disorders and suggest that trait anhedonia may be linked to a volumetric reduction in the basal ganglia and to a prefrontal functional abnormality during hedonic processing.

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Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects

Cited by 362 publications

References 0 publications

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects

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