Lacking deoxygenation‐linked interaction between cytoplasmic domain of band 3 and HbF from fetal red blood cells

Re, Weber

doi:10.1111/j.1748-1716.2007.01736.x

Cited by 2 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Foetal hemoglobin (HbF) has a higher O 2 affinity than adult haemoglobin [ 64 ] and influences erythrocyte K + transport and O 2 dependence of erythrocyte glycolysis [ 65 ]. Increased HbO 2 affinity may result in enhanced lactate formation with subsequent decrease of HCO 3 - and thus increased CO 2 /HCO 3 - ratio.…”

Section: Discussionmentioning

confidence: 99%

Anti-malarial effect of gum arabic

Ballal

Bobbala

Qadri

et al. 2011

Malar J

View full text Add to dashboard Cite

BackgroundGum Arabic (GA), a nonabsorbable nutrient from the exudate of Acacia senegal, exerts a powerful immunomodulatory effect on dendritic cells, antigen-presenting cells involved in the initiation of both innate and adaptive immunity. On the other hand GA degradation delivers short chain fatty acids, which in turn have been shown to foster the expression of foetal haemoglobin in erythrocytes. Increased levels of erythrocyte foetal haemoglobin are known to impede the intraerythrocytic growth of Plasmodium and thus confer some protection against malaria. The present study tested whether gum arabic may influence the clinical course of malaria.MethodsHuman erythrocytes were in vitro infected with Plasmodium falciparum in the absence and presence of butyrate and mice were in vivo infected with Plasmodium berghei ANKA by injecting parasitized murine erythrocytes (1 × 106) intraperitoneally. Half of the mice received gum arabic (10% in drinking water starting 10 days before the day of infection).ResultsAccording to the in vitro experiments butyrate significantly blunted parasitaemia only at concentrations much higher (3 mM) than those encountered in vivo following GA ingestion (<1 μM). According to the in vivo experiments the administration of gum arabic slightly but significantly decreased the parasitaemia and significantly extended the life span of infected mice.DiscussionGA moderately influences the parasitaemia and survival of Plasmodium-infected mice. The underlying mechanism remained, however, elusive.ConclusionsGum arabic favourably influences the course of murine malaria.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-malarial effect of gum arabic

Ballal

Bobbala

Qadri

et al. 2011

Malar J

View full text Add to dashboard Cite

show abstract

Fetal Red Blood Cells: A Comprehensive Review of Biological Properties and Implications for Neonatal Transfusion

Pellegrino,

Stone,

Valentini

et al. 2024

Cells

View full text Add to dashboard Cite

Transfusion guidelines worldwide include recommendations regarding the storage length, irradiation, or even donor cytomegalovirus serostatus of red blood cell (RBC) units for anemic neonates. Nevertheless, it is totally overlooked that RBCs of these patients fundamentally differ from those of older children and adults. These differences vary from size, shape, hemoglobin composition, and oxygen transport to membrane characteristics, cellular metabolism, and lifespan. Due to these profound dissimilarities, repeated transfusions of adult RBCs in neonates deeply modify the physiology of circulating RBC populations. Unsurprisingly, the number of RBC transfusions in preterm neonates, particularly if born before 28 weeks of gestation, predicts morbidity and mortality. This review provides a comprehensive description of the biological properties of fetal, cord blood, and neonatal RBCs, including the implications that neonatal RBCs, and their replacement by adult RBCs, may have for perinatal disease pathophysiology.

show abstract

Lacking deoxygenation‐linked interaction between cytoplasmic domain of band 3 and HbF from fetal red blood cells

Cited by 2 publications

References 33 publications

Anti-malarial effect of gum arabic

Anti-malarial effect of gum arabic

Fetal Red Blood Cells: A Comprehensive Review of Biological Properties and Implications for Neonatal Transfusion

Contact Info

Product

Resources

About