2016
DOI: 10.1111/ane.12691
|View full text |Cite
|
Sign up to set email alerts
|

Lacosamide and sodium channel-blocking antiepileptic drug cross-titration against levetiracetam background therapy

Abstract: ObjectiveTo assess prospectively the effectiveness of lacosamide (LCM) added to levetiracetam (LEV) after down‐titration of a concomitant sodium channel blocker (SCB) among patients with focal epilepsy not adequately controlled on LEV and SCB.MethodsIn this open‐label trial, LCM was initiated at 100 mg/day and up‐titrated to 200‐600 mg/day over 9 weeks; SCB down‐titration started when LCM dose reached 200 mg/day. Patients remained on stable LCM/LEV doses for 12 weeks’ maintenance (21‐week treatment period). Th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
9
1

Year Published

2018
2018
2022
2022

Publication Types

Select...
7
1
1

Relationship

1
8

Authors

Journals

citations
Cited by 15 publications
(11 citation statements)
references
References 26 publications
1
9
1
Order By: Relevance
“…Though not significant, those who were concomitantly receiving sodium channel blocking AEDs in this study had higher frequency of dizziness compared to subjects receiving non-sodium channel blocking AEDs. This is in accordance with the study by Novy et al, in which lacosamide when concomitantly administered with other sodium channel blocking AEDs was observed to cause increased side effects (diplopia, dizziness, drowsiness) [21] .…”
Section: Pre and Post Lacosamide Cognitionsupporting
confidence: 93%
“…Though not significant, those who were concomitantly receiving sodium channel blocking AEDs in this study had higher frequency of dizziness compared to subjects receiving non-sodium channel blocking AEDs. This is in accordance with the study by Novy et al, in which lacosamide when concomitantly administered with other sodium channel blocking AEDs was observed to cause increased side effects (diplopia, dizziness, drowsiness) [21] .…”
Section: Pre and Post Lacosamide Cognitionsupporting
confidence: 93%
“…This is in accordance with the study by Novy et al, in which lacosamide when concomitantly administered with other sodium channel blocking AEDs was observed to cause increased side effects (diplopia, dizziness, drowsiness). [20] In the present study, comparison of on-treatment versus baseline ECG results did not demonstrate any change in heart rate, PR interval, QT interval, or QRS duration in the study subjects. No cardiac adverse events were reported during the study period.…”
Section: Discussioncontrasting
confidence: 48%
“…Indeed, cross-titration and flexible titration have previously been suggested as feasible and practical approaches for dosing lacosamide while minimizing pharmacodynamic interactions with a sodium channel blocking AED. 21 The incidence of ADRs in patients aged ≥65 years (16.4%) tended to be higher than that observed in those aged <65 years (10.0%).…”
Section: Discussionmentioning
confidence: 77%
“…While the low documented incidence of dizziness may indicate a level of underreporting of less severe AEs in retrospective studies, it may also be possible that the incidence of this ADR is lower in clinical practice due to individualized titration (usually slower than in clinical trials) and dosing. Indeed, cross‐titration and flexible titration have previously been suggested as feasible and practical approaches for dosing lacosamide while minimizing pharmacodynamic interactions with a sodium channel blocking AED 21. The incidence of ADRs in patients aged ≥65 years (16.4%) tended to be higher than that observed in those aged <65 years (10.0%).…”
Section: Discussionmentioning
confidence: 99%