Lacrimal Duct Occlusion for the Treatment of Dry Eye

Hamano, Takashi

doi:10.1080/08820530590931133

Cited by 19 publications

(17 citation statements)

References 45 publications

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“…Intra-canalicular plugs may predispose to infection by leading to stasis or obstruction of tear flow, whereas punctal plugs may lead to the formation of biofilms [5][6][7][8][9]. In addition, despite the fact that punctal/intra-canalicular plugs are designed to be inert, it remains possible that they may act as a foreign body inciting a localised inflammatory reaction, thereby increasing the risk of infection within the canaliculus.…”

Section: Discussionmentioning

confidence: 93%

“…Canaliculitis is a recognised complication of punctal plugs, but has not previously been described following insertion of newer generation intra-canalicular plugs such as the SmartPLUG [5][6][7][8][9]. We report a case of bilateral canaliculitis following SmartPLUG insertion for dry eye post LASIK surgery.…”

Section: Introductionmentioning

confidence: 85%

“…collagen plugs) or semi-permanent (e.g. umbrella-type silicone plugs) treatments are generally preferred [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Bilateral canaliculitis following SmartPLUG insertion for dry eye syndrome post LASIK surgery

Scheepers

Pearson

Michaelides

2006

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 85%

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Bilateral canaliculitis following SmartPLUG insertion for dry eye syndrome post LASIK surgery

Scheepers

Pearson

Michaelides

2006

Graefe's Arch Clin Exp Ophthalmol

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“…Many investigators have published reviews of punctal plug use for dry eye syndrome (Hamano 2005; Marcet 2015; Yellepeddi 2015; Jehangir 2016). Nevertheless, these reviews do not include meta-analyses of randomized controlled trials or other comparative studies.…”

Section: Discussionmentioning

confidence: 99%

Punctal occlusion for dry eye syndrome

Ervin

Law

Pucker

2017

Cochrane Database of Systematic Reviews

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Background Dry eye syndrome is a disorder of the tear film that is associated with symptoms of ocular discomfort. Punctal occlusion is a mechanical treatment that blocks the tear drainage system in order to aid in the preservation of natural tears on the ocular surface. Objectives To assess the effects of punctal plugs versus no punctal plugs, different types of punctal plugs, and other interventions for managing dry eye. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 11), MEDLINE Ovid (1946 to 8 December 2016), Embase.com (1947 to 8 December 2016), PubMed (1948 to 8 December 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 8 December 2016), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com; last searched 18 November 2012 - this resource is now archived), ClinicalTrials.gov (www.clinicaltrials.gov; searched 8 December 2016), and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en; searched 8 December 2016). We did not use any date or language restrictions in the electronic searches for trials. We also searched the Science Citation Index-Expanded database and reference lists of included studies. The evidence was last updated on 8 December 2016 Selection criteria We included randomized and quasi-randomized controlled trials of collagen or silicone punctal plugs in symptomatic participants diagnosed with aqueous tear deficiency or dry eye syndrome. Data collection and analysis Two review authors independently assessed trial quality and extracted data. We contacted study investigators for additional information when needed. Main results We included 18 trials (711 participants, 1249 eyes) from Austria, Canada, China, Greece, Japan, Mexico, Netherlands, Turkey, the UK, and the USA in this review. We also identified one ongoing trial. Overall we judged these trials to be at unclear risk of bias because they were poorly reported. We assessed the evidence for eight comparisons. Five trials compared punctal plugs with no punctal plugs (control). Three of these trials employed a sham treatment and two trials observed the control group. Two trials did not report outcome data relevant to this review. There was very low-certainty evidence on symptomatic improvement. The three trials that reported this outcome used different scales to measure symptoms. In all three trials, there was little or no improvement in symptom scores with punctal plugs compared with no punctal plugs. Low-certainty evidence from one trial suggested less ocular surface staining in the punctal plug group compared with the no punctal plug group however this difference was small and possibly clinically unimportant (mean difference (MD) in fluorescein staining score -1.50 points, 95% CI -1.88 to -1.12; eyes = 61). Similarly there was a small difference in tear film stability with people in the punctal plug group having more stabili...

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“…Insertion of puncta plugs has been reported to improve disorders related to inflammation of conjunctival and corneal epithelial cells [10], and also improve vision for dry eye patients [11]. While puncta plugs are useful, these suffer from the drawback of patient discomfort, difficulty of insertion and potential loss of plug during wear.…”

Section: Introductionmentioning

confidence: 99%