Lacrimal Gland Tumors

Proia, Alan D.; Ranjit-Reeves, Roshni; Woodward, Julie

doi:10.1097/iio.0000000000000220

Cited by 3 publications

(2 citation statements)

References 180 publications

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“…The distinguishing features were the absence of pain, paresthesia or bone changes, which are more suggestive of malignancy yet also inconsistently present in orbital lobe tumors. 25 The more anterior location of these palpebral lobe lesions, with no contact with the orbital rim, may also justify the absence of earlier bone changes. Two cases of palpebral lobe ACC are, however, insufficient to draw any conclusions about its specific behavior in this anatomic area.…”

Section: Discussionmentioning

confidence: 99%

“…All the prognostic factors for local recurrence and survival were considered, namely the lesion size (T1N0M0 according to the American Joint Committee on Cancer classification, 8 th edition), the histologic type (non-basaloid) and the absence of perineural invasion. 25,32,40 Importantly, the decision also depended on the patient's commitment to maintaining a strict clinical and radiologic surveillance. In summary, we report the exceedingly rare occurrence of an ACC of the palpebral lobe of the LG, illustrating the importance of maintaining a high level of suspicion for any temporally located upper eyelid mass.…”

Section: Discussionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the palpebral lobe of the lacrimal gland – case report and literature review

Duarte

Costa

Caçador

et al. 2021

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Epithelial tumors of the lacrimal gland are rare and usually develop in the orbital lobe. We report the exceedingly rare occurrence of a primary adenoid cystic carcinoma in the palpebral lobe of the lacrimal gland. A 26-year-old female was referred for evaluation of a gradually enlarging mass in the lateral upper eyelid, previously diagnosed as a chalazion. Computed tomography revealed a heterogeneous round lesion anterior to the orbital rim. Excisional biopsy was compatible with an adenoid cystic carcinoma. After excluding distant metastasis, and as the patient refused adjuvant radiotherapy, a second surgical procedure, with wide local excision, was indicated. Follow-up showed no recurrence. This case highlights the importance of performing a thorough clinical examination when diagnosing any lateral upper eyelid mass. A high index of suspicion for malignant tumors of the lacrimal gland should always be maintained, and a complete excision with histological analysis should be preferred whenever possible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the palpebral lobe of the lacrimal gland – case report and literature review

Duarte

Costa

Caçador

et al. 2021

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Neoplasms of the Eye and Orbit

Alvarez¹,

Ponce²,

Chevez‐Barrios³

et al. 2022

Holland‐Frei Cancer Medicine

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Overview Cancers of the eye and orbit are associated with diverse pathological conditions, disease prognosis, and significant mortality. The survival rates vary among patients from different countries and have been reported to be significantly lower in those from developing countries compared to those noted in the United States owing mainly to delay in diagnosis associated with advanced‐stage disease and unavailability of treatments. In this article, we provide an overview of the most common and rare ophthalmic malignancies that include ocular surface, external and adnexal diseases, and orbital and intraocular malignancies. We summarize the incidence, histopathology, risk factors, molecular alterations, clinical presentation, diagnostic evaluation, and therapeutic approaches for these diseases. We also describe the first‐line and salvage treatments and their complications. These treatments depend on disease stage at presentation and include pathology‐guided excision, Mohs microsurgery, chemo‐reduction, chemoprophylaxis, adjuvant chemotherapy after enucleation, and/or neoadjuvant chemotherapy. Complications include symblepharon, scarring, and limbal stem cell deficiency while incomplete excision of eyelid tumors may result in recurrence of larger and more aggressive tumors. Currently, identification of genetic abnormalities identified in genomic profiling of patient tumors improves treatment selection. Early diagnosis and involvement of an ocular oncologist at the time of diagnosis will optimize the therapeutic management of patients with these diseases.

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