Lacrimal Sac Hemangiopericytoma

Gurney, Nelson; Chalkley, Thomas; O'Grady, Richard B.

doi:10.1016/0002-9394(71)90438-7

Cited by 32 publications

(2 citation statements)

References 3 publications

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“…There is no predilection for either sex. The locations ofthe tumors in recorded cases have been the muscles, retroperitoneum, omentum, orbit, tongue, nasal cavity, pericardium, diaphragm, ileum, bone, meninges, uterus, skin and subcutaneous tissues (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). The histologic appearance often fails to indicate whether the tumor is malignant or benign; even the ultramicroscopic appearance is not conclusive (3,4).…”

Section: Discussionmentioning

confidence: 99%

Metastatic Hemangiopericytoma Associated with Microangiopathic Hemolytic Anemia: Review and Report of a Case

Kupers

Friedman

Wolfstein

1975

J American Geriatrics Society

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The hemangiopericytoma is an invasive tumor of vascular origin. No matter how benign the course and how circumscribed the mass, it must be considered a lesion with high malignant potential. In the case report here, a hemangiopericytoma of the pancreas with metastasis to the liver was associated with microangiopathic hemolytic anemia in a 78-year old woman. The anemia may have been present before the onset of metastasis. If so, it could have been a major factor in the breakdown of host response and could have initiated the malignant dissemination. Under these circumstances it could be an indicator of metastasis in patients with previously diagnosed tumors. However, there are many cases of metastatic malignancy associated with this anemia in which the opposite situation holds. The anemia is usually of extracorpuscular origin. Apparently intravascular coagula1ion caused by injury from tumor-cell aggregates in small vessels induces erythrocyte fragmentation in fibrin strands. A vicious cycle of cell fragmentation, vascular injury and fibrin strand formation completes the course. Analysis of the findings should be based upon more than a strictly pathologic approach; it should also be related to the new discoveries in cancer research.

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Section: Discussionmentioning

confidence: 99%

Metastatic Hemangiopericytoma Associated with Microangiopathic Hemolytic Anemia: Review and Report of a Case

Kupers

Friedman

Wolfstein

1975

J American Geriatrics Society

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“…An uncommon tumor in the field of ophthalmic pathology, HPCT is usually encountered in the orbit, 2 but may originate in conjunctiva, 3,4 choroid, 5 optic nerve, 6 or medial canthal skin. 7 Its occurrence in the lacrimal sac is rare (found in about 1% of sac tumors); only 7 cases have been reported 1,[8][9][10][11][12][13] (Table). While orbital HPCT usually appears at the median and mean age of approximately 42 years, 2 the earlier onset of lacrimal sac HPCT (third to fifth decades of life) 1,8-13 probably relates to its relatively noticeable, symptomatic periocular location when small.…”

Section: Commentmentioning

confidence: 99%