Lacrimal System Obstruction After Radioiodine Therapy in Differentiated Thyroid Carcinomas: A Prospective Comparative Study

Fonseca, Fabricio Lopes da; Yamanaka, Patricia Kazue; Kato, Juliana Mika; Matayoshi, Suzana

doi:10.1089/thy.2015.0657

Cited by 21 publications

(23 citation statements)

References 36 publications

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“…Studies of diseased state microbiota have been conducted in patients with dry eyes ( Willis et al, 2020 ; Andersson et al, 2021 ), obstruction ( Curragh et al, 2020 ), and Sjogren’s syndrome ( Trujillo-Vargas et al, 2020 ). Although dry eyes are a known side effect of radiotherapy ( Nuzzi et al, 2020 ) and radioiodine treatments ( da Fonseca et al, 2016 ), research in the area of radiation impact on the lacrimal or ocular microbiota has yet to be conducted.…”

Section: The Effects Of Radiation On the Microbiomementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

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Study of the human microbiota has been a centuries-long endeavor, but since the inception of the National Institutes of Health (NIH) Human Microbiome Project in 2007, research has greatly expanded, including the space involving radiation injury. As acute radiation syndrome (ARS) is multisystemic, the microbiome niches across all areas of the body may be affected. This review highlights advances in radiation research examining the effect of irradiation on the microbiome and its potential use as a target for medical countermeasures or biodosimetry approaches, or as a medical countermeasure itself. The authors also address animal model considerations for designing studies, and the potential to use the microbiome as a biomarker to assess radiation exposure and predict outcome. Recent research has shown that the microbiome holds enormous potential for mitigation of radiation injury, in the context of both radiotherapy and radiological/nuclear public health emergencies. Gaps still exist, but the field is moving forward with much promise.

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Section: The Effects Of Radiation On the Microbiomementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

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“…Nasolacrimal duct obstruction has been associated with high-dose radioiodine therapy (Kloos et al 2002, Ali 2016, da Fonseca et al 2016. Morgenstern et al (2005) showed that NIS mRNA was detected in normal lacrimal sacs via RT-PCR and NIS immunostaining was detected at the basolateral membrane of the stratified columnar epithelial cells in the lacrimal sac (Fig.…”

Section: Nis Expression In Lacrimal Sac and Nasolacrimal Ductmentioning

confidence: 99%

Na+/I− symporter expression, function, and regulation in non-thyroidal tissues and impact on thyroid cancer therapy

Jhiang

Sipos

2021

Endocrine-Related Cancer

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Radioiodine (131I) has been used to ablate thyroid tissue not removed by surgery or to treat differentiated thyroid cancer that has metastasized to other parts of the body for the past 80 years. However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues. This NIS expression permits 131I accumulation and radiation damage in these non-target tissues, which accounts for the adverse effects of radioiodine therapy. We will review the data regarding the expression, function, and regulation of NIS in non-thyroidal tissues. We will explain the seemingly paradoxical adverse effects induced by 131I: the self-limited gastrointestinal adverse effects in contrast to the permanent salivary dysfunction that is seen after 131I therapy. We propose that prospective studies are needed to uncover the time-course of pathological processes underlying development and progression or ultimate resolution of 131I-induced salivary ductal obstruction and nasolacrimal duct obstruction. Finally, preventive measures and early therapeutic interventions that can be applied potentially to eliminate or alleviate long-term radioiodine adverse effects will be discussed.

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“… 1 Epiphora and nasolacrimal duct obstruction have also been reported as adverse effects. 3 , 4 Da Fonseca et al 5 conducted a prospective study to evaluate the effect of iodine-131 on the lacrimal drainage system. They reported that the rate of lacrimal system obstruction is 6.8% until 12 months after RAI.…”

Section: Introductionmentioning

confidence: 99%

Lacrimal System Obstruction After Radioiodine Therapy in Differentiated Thyroid Carcinomas: A Prospective Comparative Study

Cited by 21 publications

References 36 publications

Acute Radiation Syndrome and the Microbiome: Impact and Review

Acute Radiation Syndrome and the Microbiome: Impact and Review

Na+/I− symporter expression, function, and regulation in non-thyroidal tissues and impact on thyroid cancer therapy

Dacryoendoscopic recanalization of lacrimal passage obstruction/stenosis after radioiodine therapy for differentiated thyroid carcinoma

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