Lactase in Man: A Nonadaptable Enzyme

Gilat, Tuvia; Russo, Salvatore F.; Gelman-Malachi, E; Aldor, T. A. M.

doi:10.1016/s0016-5085(72)80080-5

Cited by 100 publications

(25 citation statements)

References 22 publications

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“…Suspecting that earlier feeding experiments in humans had not been of sufficiently long duration, Kretchmer (69), Gilat (44) and Gilat et al (45) organized experiments which lasted for 6 months and from 6 to 14 months, respectively. Kretchmer was unable to increase the lactose absorption ability of Nigerian medical students who had hypolactasia, and Gilat et al found no change in jejunal lactase activity in Jews even after a 1-year period of lactose feeding.…”

Section: Adaptive Changes In Human Lactasementioning

confidence: 99%

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Hypolactasia and Lactase Persistence Historical Review and the Terminology

Sahi

1994

Scandinavian Journal of Gastroenterology

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and Headquarters of the Frontier Guard, Helsinki, Finland Sahi T. Hypolactasia and lactase persistence. Historical review and the terminology. %and J Gastroenterol 19!44;29 Suppl202:1-6.Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century. In 1903, it was found that the dog had a very low lactase activity and therefore lactose remained unhydrolysed, causing diarrhoea. Human hypolactasia was demonstrated in 1%3, and it was soon found that it is very common, commoner than lactase persistence in most parts of the world. In 1973, adult-type hypolactasia was shown to be inherited by an autosomal recessive single gene. This article reviews the early expansion of the knowledge on lactase and hypolactasia as well as the correct terminology.(47) * Scand J Gastroenterol Downloaded from informahealthcare.com by Indiana University on 12/13/14For personal use only.

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Section: Adaptive Changes In Human Lactasementioning

confidence: 99%

“…It has in fact two enzyme activities, phlorizin hydrolase (EC 3.2.1.62) and glycosylceramidase (EC 3.2.1. [45][46]. The molecular weight of the enzyme is 160,000kDa (see e.g.…”

mentioning

confidence: 99%

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Sahi

1994

Scandinavian Journal of Gastroenterology

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“…Gilat et al (28) carried out a more prolonged test which could be presented as an instruction for practical management. Ten lactase-deficient volunteers aged 21 to 65 years were asked to drink gradually increasing amounts of milk several times a day up to a total of at least 1 litre per day.…”

Section: Adaptation To Lactosementioning

confidence: 99%

Management of Lactose Intolerance

Tamm

1994

Scandinavian Journal of Gastroenterology

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“…The preferred term for this type of hypolactasia is lactase nonpersistence (LNP). This permanent loss of lactase occurs sometime after 3À5 years of age [9,18]. Thus, LNP is not a "lactase deficiency" disease but is the normal pattern in human physiology, similar to the physiology of other mammalian species.…”

Section: Loss Of Lactase Activitymentioning

confidence: 98%