2019
DOI: 10.1016/j.tibs.2018.10.011
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Lactate: A Metabolic Driver in the Tumour Landscape

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Cited by 343 publications
(336 citation statements)
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“…Currently it is acknowledged that lactate is not just a waste metabolite but an important oncometabolite in the tumor microenvironment that is involved in tumor aggressiveness and metastasis [9]. However, the underlying mechanism is not well understood, and a metabolic-epigenetic relationship has been proposed.…”
Section: Discussionmentioning
confidence: 99%
“…Currently it is acknowledged that lactate is not just a waste metabolite but an important oncometabolite in the tumor microenvironment that is involved in tumor aggressiveness and metastasis [9]. However, the underlying mechanism is not well understood, and a metabolic-epigenetic relationship has been proposed.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, we found that cell apoptosis induced by circNFIX knockdown might be associated with cell cycle arrest at G0-G1 phase. Moreover, glycolysis is an important way to maintain cell survival in cancers including glioma and lactate is a key product as a biomarker of malignancy [21][22][23]. And HK2 is a key enzyme during glucose metabolism in glycolysis [24].…”
Section: Discussionmentioning
confidence: 99%
“…Lactate is formed exclusively from pyruvate regardless of oxygen availability, and robustly exported to the TME, reaching concentrations that can be 20-fold higher (about 40 mM) (74) than in non-tumoral tissues (about 1.5-3 mM) (13,15). Lactate is a major fuel source, providing energetic and anabolic support to cancer cells, and an important oncometabolite with both extracellular and intracellular signaling functions that equally contribute to cancer progression (Figure 1) (75,76).…”
Section: Lactate Roles In the Tumor Microenvironment: From Metabolic mentioning
confidence: 99%