Lactate dehydrogenase/albumin ratio as a prognostic factor in severe acute respiratory distress syndrome cases associated with COVID-19

Sipahioğlu, Hilal; Onuk, Sevda

doi:10.1097/md.0000000000030759

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…Thus, the index [Urea] × [MDA]/(BChEb × [ALB]) can claim to take a place among the most promising indices proposed to date, among which there is none that includes the activity of BChE and at the same time demonstrates such striking differences at the stage of admission to the clinic between survivors and those who died during treatment from COVID-19. At the same time, it should be mentioned that most of the proposed indices include albumin in the denominator: LDH/[ALB], [Lact]/[ALB], [Fibr]/[ALB], [Urea]/[ALB], and [CRP]/[ALB] [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Importantly, correlation analysis independent of age and concomitant pathology showed that the ratio of [CRP]/[ALB] negatively correlates with oxygen saturation (SO 2 ), spirometric indices (FEV1, forced expiratory volume in the first second, and FVC, forced volume capacity) and lung diffusion values (DLCO, carbon monoxide diffusion capacity) [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…[Urea]/[ALB], and [CRP]/[ALB] [42][43][44][45][46][47][48][49][50][51]. Importantly, correlation analysis independent of age and concomitant pathology showed that the ratio of [CRP]/[ALB] negatively correlates with oxygen saturation (SO 2 ), spirometric indices (FEV1, forced expiratory volume in the first second, and FVC, forced volume capacity) and lung diffusion values (DLCO, carbon monoxide diffusion capacity) [52].…”

Section: Comparative Analysis Of Esterase Status Of Survivors and Dec...mentioning

confidence: 99%

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Albumin Is a Component of the Esterase Status of Human Blood Plasma

Belinskaia

Voronina

Попова

et al. 2023

IJMS

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The esterase status of blood plasma can claim to be one of the universal markers of various diseases; therefore, it deserves attention when searching for markers of the severity of COVID-19 and other infectious and non-infectious pathologies. When analyzing the esterase status of blood plasma, the esterase activity of serum albumin, which is the major protein in the blood of mammals, should not be ignored. The purpose of this study is to expand understanding of the esterase status of blood plasma and to evaluate the relationship of the esterase status, which includes information on the amount and enzymatic activity of human serum albumin (HSA), with other biochemical parameters of human blood, using the example of surviving and deceased patients with confirmed COVID-19. In experiments in vitro and in silico, the activity of human plasma and pure HSA towards various substrates was studied, and the effect of various inhibitors on this activity was tested. Then, a comparative analysis of the esterase status and a number of basic biochemical parameters of the blood plasma of healthy subjects and patients with confirmed COVID-19 was performed. Statistically significant differences have been found in esterase status and biochemical indices (including albumin levels) between healthy subjects and patients with COVID-19, as well as between surviving and deceased patients. Additional evidence has been obtained for the importance of albumin as a diagnostic marker. Of particular interest is a new index, [Urea] × [MDA] × 1000/(BChEb × [ALB]), which in the group of deceased patients was 10 times higher than in the group of survivors and 26 times higher than the value in the group of apparently healthy elderly subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Comparative Analysis Of Esterase Status Of Survivors and Dec...mentioning

confidence: 99%

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Belinskaia

Voronina

Попова

et al. 2023

IJMS

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“…One previous study showed that LAR was an independent risk factor for mortality for the patients with ARDS due to COVID-19 ( 12 ), but the study only revealed the relationship between LAR and the death outcome, which may not reflect the overall dynamics of the patient’s condition.…”

Section: Introductionmentioning

confidence: 91%

Prognostic value of lactic dehydrogenase-to-albumin ratio in critically ill patients with acute respiratory distress syndrome: a retrospective cohort study

Zhang,

Niu

et al. 2024

J Thorac Dis

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Background Lactic dehydrogenase (LDH)-to-albumin ratio (LAR) was an independent risk factor for mortality in the patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19), while the relationship among LAR and short-term, long-term, in-hospital mortalities of ARDS remains unclear. The current study aims to investigate the association between LAR and significant prognosis in patients with ARDS. Methods We conducted a retrospective cohort study and analyzed patients with ARDS on the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.0 database. In the current study, 30-day mortality was defined as the primary outcome; 90-day mortality and in-hospital mortality were defined as secondary outcomes. Multivariate regression analysis, Kaplan-Meier curve analysis and subgroup analysis were performed to research the association between LAR and prognosis in patients with ARDS. Results A total of 358 critically ill patients with ARDS were enrolled in the current study. The mean age of the participants was 62.6±16.0 and the median of LAR was 14.3. According to the Kaplan-Meier curve analysis, the higher LAR group had a higher 30-day, 90-day and in-hospital mortalities. We also analyzed the 30-day mortality to receiver operating characteristic (ROC) curves by comparing the value between LAR and LAR + simplified acute physiology score II (SAPS II). The area under the curve (AUC) of the LAR group was 0.694 [95% confidence interval (CI): 0.634–0.754, P<0.001], and 0.661 for the LAR + SAPS II (95% CI: 0.599–0.722, P<0.001). For 30-day mortality, after adjusting for covariates, hazard ratios (HRs) (95% CIs) for tertile 2 (LAR 8.7–30.9) and tertile 3 (LAR >30.9) were 2.00 (1.37, 2.92) and 2.50 (1.50, 4.15), respectively. Similar results were also observed for 90-day mortality and in-hospital mortality. Conclusions Elevated LAR levels are associated with increased 30- and 90-day mortalities, as well as in-hospital mortality in patients with ARDS, which means LAR levels may predict the mortalities of ARDS patients.

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“…[Lactate]/[ALB], [Fibrinogen]/[ALB], [Urea]/[ALB], and [CRP]/[ALB] [24][25][26][27][28][29][30][31][32][33]. It is important to note that correlation analysis, regardless of age and comorbidity, showed that the [CRP]/[ALB] ratio negatively correlates with oxygen saturation (SO 2 ), spirometric parameters (FEV1, forced expiratory volume in the first second; FVC, forced vital capacity), and lung diffusion values (DLCO, diffusion lung capacity for carbon monoxide) [34].…”

Section: Introductionmentioning

confidence: 99%

Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study

Goncharov,

Avdonin,

Voitenko

et al. 2023

Metabolites

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During the initial diagnosis of urgent medical conditions, which include acute infectious diseases, it is important to assess the severity of the patient’s clinical state as quickly as possible. Unlike individual biochemical or physiological indicators, derived indices make it possible to better characterize a complex syndrome as a set of symptoms, and therefore quickly take a set of adequate measures. Recently, we reported on novel diagnostic indices containing butyrylcholinesterase (BChE) activity, which is decreased in COVID-19 patients. Also, in these patients, the secretion of von Willebrand factor (vWF) increases, which leads to thrombosis in the microvascular bed. The objective of this study was the determination of the concentration and activity of vWF in patients with COVID-19, and the search for new diagnostic indices. One of the main objectives was to compare the prognostic values of some individual and newly derived indices. Patients with COVID-19 were retrospectively divided into two groups: survivors (n = 77) and deceased (n = 24). According to clinical symptoms and computed tomography (CT) results, the course of disease was predominantly moderate in severity. The first blood sample (first point) was taken upon admission to the hospital, the second sample (second point)—within 4–6 days after admission. Along with the standard spectrum of biochemical indicators, BChE activity (BChEa or BChEb for acetylthiocholin or butyrylthiocholin, respectively), malondialdehyde (MDA), and vWF analysis (its antigen level, AGFW, and its activity, ActWF) were determined and new diagnostic indices were derived. The pooled sensitivity, specificity, and area under the receiver operating curve (AUC), as well as Likelihood ratio (LR) and Odds ratio (OR) were calculated. The level of vWF antigen in the deceased group was 1.5-fold higher than the level in the group of survivors. Indices that include vWF antigen levels are superior to indices using vWF activity. It was found that the index [Urea] × [AGWF] × 1000/(BChEb × [ALB]) had the best discriminatory power to predict COVID-19 mortality (AUC = 0.91 [0.83, 1.00], p < 0.0001; OR = 72.0 [7.5, 689], p = 0.0002). In addition, [Urea] × 1000/(BChEb × [ALB]) was a good predictor of mortality (AUC = 0.95 [0.89, 1.00], p < 0.0001; OR = 31.5 [3.4, 293], p = 0.0024). The index [Urea] × [AGWF] × 1000/(BChEb × [ALB]) was the best predictor of mortality associated with COVID-19 infection, followed by [Urea] × 1000/(BChEb × [ALB]). After validation in a subsequent cohort, these two indices could be recommended for diagnostic laboratories.

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Lactate dehydrogenase/albumin ratio as a prognostic factor in severe acute respiratory distress syndrome cases associated with COVID-19

Cited by 8 publications

References 49 publications

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Prognostic value of lactic dehydrogenase-to-albumin ratio in critically ill patients with acute respiratory distress syndrome: a retrospective cohort study

Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study

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