Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

Nandita, Ahanthem; Basavaraju, Sowbhagya Malligere; Pachipulusu, Balaji

doi:10.5005/jp-journals-10052-0108

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…The studies by Nandita et al, 2017;Rathore et al, 2015;Pereira et al, 2015 analysed the data of premalignant lesions separately by categorising the study groups into OSMF group, Leukoplakia group and lichen planus group. Therefore, the study parameters were extracted separately for the data analysis under different PMDs of interest.…”

Section: Resultsmentioning

confidence: 99%

“…The metanalysis included nine studies and demonstrated a significant increase in serum LDH level among patients with potentially malignant disorders including OSMF, leukoplakia and lichen planus. All the nine observational studies in the meta-analysis (Chari et al, 2016;Mishra et al, 2018;Mohan et al, 2017;Nalin et al, 2018;Nandita et al, 2017;Pereira et al, 2015;Rathore et al, 2015;Sharma et al, 2016;Swamy and Ganiger et al, 2016) reported a higher level of mean serum LDH for PMDs compared to Oral cancer often presents a clinical diagnostic challenge to the dental practitioner, particularly in its early stage of development. Typically, they tend to be preceded by a potentially malignant state for a long time (Macdonald et al, 1957;Nair et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Serum Lactate Dehydrogenase Enzyme as a Tumor Marker in Potentially Malignant Disorders: A Systematic Review and Meta–Analysis

Barbi

Purohit

2022

Asian Pac J Cancer Prev

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Background: Oral cancer is often preceded by Potentially Malignant Disorders (PMDs) and important role of biochemical markers for early diagnosis has been well documented; however, there is limited evidence of Serum lactate dehydrogenase (SLDH) as an effective biochemical marker in diagnosis of PMDs. The present meta-analysis was conducted to assess if serum LDH can be a used as standard biomarker for PMDs and consequently aid in diagnosis of oral cancer. Methods: A comprehensive search was conducted in Medline, Scopus, Web of Science, EBSCO host, Cochrane databases and Google Scholar for studies evaluating estimation of SLDH in PMDs. Search strategy included all types of studies evaluating level of SLDH in patients with PMDs. PRISMA guidelines were followed for the metaanalysis. Fixed-effects model was used to assess the mean differences in SLDH levels between healthy controls and PMDs. Results: A total number of nine studies were included in meta-analysis after screening for inclusion and exclusion criteria. Potentially malignant disorder was significantly associated with increased serum LDH level compared to healthy controls (pooled SMD: 1.83 (95% CI, 1.52, 2.15) (P < 0.00001; Subgroup analysis of OSMF (Oral Submucous Fibrosis) studies showed significant association with increased serum LDH level compared to healthy controls (pooled SMD: 2.57 (95% CI, 2.16, 2.98; P < 0.00001). Sensitivity analysis for the five studies reflected a significant reduction in I 2 values to 24 % (P=0.26). Funnel plots were derived for any evidence of publication bias among the studies. Conclusion: Meta-analysis suggests that SLDH is increased in potentially malignant disorders compared to healthy controls. The results of this metanalysis should encourage use of SLDH as a biomarker in diagnosis of PMDs.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Lactate Dehydrogenase Enzyme as a Tumor Marker in Potentially Malignant Disorders: A Systematic Review and Meta–Analysis

Barbi

Purohit

2022

Asian Pac J Cancer Prev

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“…It has been reported that LDH, marker of anaerobic metabolism, is associated with highly invasive and metastatic breast cancer and suggested that the association of activity of LDH in tumor tissue with mammographic characteristics could help in defining aggressive breast cancers [8]. The gene expression of LDH is studied in several human malignant tumors, collectively among colorectal cancer [9], lung cancer [10][11][12], breast cancer [13], oral cancer [14], prostate cancer [15], germ cell cancer [16], and pancreatic cancer [17]. In recent times, the prognostic value of the serum LDH level in cancer patients has been considered as a significant area of research.…”

Section: Oxidoreductase-based Diagnostic Tests and As Biosensorsmentioning

confidence: 99%

Applications of Oxidoreductases

Gogoi¹

2021

Oxidoreductase

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Oxidoreductases comprise of a large group of enzymes catalyzing the transfer of electrons from an electron donor to an electron acceptor molecule, commonly taking nicotinamide adenine dinucleotide phosphate (NADP) or nicotinamide adenine dinucleotide (NAD) as cofactors. Research on the potential applications of oxidoreductases on the growth of oxidoreductase-based diagnostic tests and better biosensors, in the design of inventive systems for crucial coenzymes regeneration, and in the creation of oxidoreductase-based approaches for synthesis of polymers and oxyfunctionalized organic substrates have made great progress. This chapter focuses on biocatalytic applications of oxidoreductases, since many chemical and biochemical transformations involve oxidation/reduction processes, developing practical applications of oxidoreductases has long been a significant target in biotechnology. Oxidoreductases are appropriate catalysts owing to their biodegradability, specificity and efficiency and may be employed as improved biocatalysts to substitute the toxic/expensive chemicals, save on energy/resources consumption, generate novel functionalities, or reduce complicated impacts on environment.

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“…The role of saliva as a potential diagnostic tool in the detection of manifold oral diseases has been duly established by numerous studies. [ 2 3 4 ] This has encouraged studies on LDH activity to be conducted on salivary samples. [ 5 ] In a recent study, LDH levels in both active and passive smokers were gleaned and compared for the first time along with control individuals.…”

mentioning

confidence: 99%

“…The results demonstrated that increased levels of LDH-2, -3, -4 were detected in OPMD, and the levels rose further in oral cancer patients. [ 4 10 ] Another study assessed LDH levels in saliva and serum of patients afflicted with oral submucous fibrosis (OSMF) and leukoplakia. The results indicated a good correlation between serum and salivary LDH levels in OSMF patients, whereas a strong positive correlation was established in leukoplakia patients, thereby corroborating saliva as a propitious tool for early detection of OPMD.…”

mentioning

confidence: 99%