Lactate Dehydrogenase: Physiological Roles and Clinical Implications

Alkhatib, Ahed J; Alrakaf, Nawaf Abduallah Mohammad

doi:10.34297/ajbsr.2019.03.000705

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Mainly, LDH acts through oxidation process on pyruvate to be converted into lactate. It is worth to mention that LDH is mainly localized in the cytoplasm of cell and becomes extracellular when cell dies ( 8 , 9 ). It has been argued that LDH concentrations are varied based on energy requirements of different tissues ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Dmour¹,

Khreisat²,

Khreisat³

et al. 2020

Med Arch

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Section: Introductionmentioning

confidence: 99%

Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Dmour¹,

Khreisat²,

Khreisat³

et al. 2020

Med Arch

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Antiglycative Effect of Combination of Extracts of Capsicum annuum (chilli) and Pyridoxamine Against Glycation in Streptozotocin-induced Experimental Diabetes in Rats

İnceören,

Akay,

Nas

et al. 2023

Rev. Bras. Farmacogn.

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Clinical Role of Serum Lactate Dehydrogenase Assessment in Critically Ill Pediatric Patients with Sepsis

Mohamed

Youness

2021

Biomed. Pharmacol. J.

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Sepsis is a systemic inflammatory disorder that may be associated with higher rate of morbidity and mortality in pediatric patients admitted to intensive care unit with sepsis. Usage of different biomarkers may be helpful for early detection and appropriate management of sepsis. Our objectives was to investigate the role of serum lactate dehydrogenase in prediction of sepsis in critical pediatric patients, and its relation with prognostic scoring systems. A prospective cohort study was conducted at El Galaa teaching hospital between January 2020 and December 2020. A total of 168 pediatric patients were divided into the septic group (84) critically ill patients with sepsis from the pediatric intensive care unit (PICU)] and control group (84 stable patients admitted to the inpatient word). Demographic and clinical data were collected, routine laboratory investigation including LDH on admission and after 24 hours were performed. Pediatric Risk of Mortality III (PRISMIII) and Sequential Organ Failure Assessment (pSOFA) were assessed. Serum LDH level was significantly higher in septic group than control (P=0.000) and in non-survivor than survivor group (P=0.000). Also there was statistically significant correlation between survivor and non-survivor as regarding length of hospitality, pSOFA score and PRISMIII score. There was statistically significant positive correlation between LDH, PRISMIII (r=0.842, P<0.001) and pSOFA (r=0.785, P<0.001). We concluded that LDH is a useful marker in predicting of sepsis in critically ill pediatric patients especially when combined with prognostic scoring systems.

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Lactate Dehydrogenase: Physiological Roles and Clinical Implications

Cited by 5 publications

References 16 publications

Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Antiglycative Effect of Combination of Extracts of Capsicum annuum (chilli) and Pyridoxamine Against Glycation in Streptozotocin-induced Experimental Diabetes in Rats

Clinical Role of Serum Lactate Dehydrogenase Assessment in Critically Ill Pediatric Patients with Sepsis

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