2017
DOI: 10.1002/pros.23373
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Lactate dehydrogenase predicts combined progression‐free survival after sequential therapy with abiraterone and enzalutamide for patients with castration‐resistant prostate cancer

Abstract: The results of this study suggested the A-E sequence had longer combined PSA and total PSA-PFS compared to the E-A sequence in patients with CRPC. LDH values in sequential therapy may serve as a predictor of longer combined PFS.

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Cited by 32 publications
(42 citation statements)
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“…There have been a number of studies reporting sequential use of ASIs, namely enzalutamide followed by abiraterone [28][29][30][31][32] and abiraterone followed by enzalutamide (Table 3). [31][32][33][34][35][36][37][38] Data seem to show a blunted effect of each after the use of the other, suggesting cross-resistance.…”
Section: Sequential Therapy Using Asismentioning
confidence: 99%
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“…There have been a number of studies reporting sequential use of ASIs, namely enzalutamide followed by abiraterone [28][29][30][31][32] and abiraterone followed by enzalutamide (Table 3). [31][32][33][34][35][36][37][38] Data seem to show a blunted effect of each after the use of the other, suggesting cross-resistance.…”
Section: Sequential Therapy Using Asismentioning
confidence: 99%
“…[31][32][33][34][35][36][37][38] Data seem to show a blunted effect of each after the use of the other, suggesting cross-resistance. It remains unclear which patients benefit from one agent as the first agent compared with the other.…”
Section: Sequential Therapy Using Asismentioning
confidence: 99%
“…Information on the included studies is presented in Table 1. All five studies were retrospective case-control studies [16][17][18][19][20].…”
Section: Systematic Review Processmentioning
confidence: 99%
“…Three were conducted in Japan [17,18,20], one in the United States [19], and one in Japan and the United States [16]. Patients enrolled in the Maughan et al study were also participants in the Terada et al study [16,19].…”
Section: Systematic Review Processmentioning
confidence: 99%
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